Response to intracrevicular controlled delivery of 25% tetracycline from poly(lactide/glycolide) film strips in SPT patients

G. I. Maze, Richard A Reinhardt, R. K. Agarwal, J. K. Dyer, D. H. Robinson, L. M. DuBois, Gerald James Tussing, C. R. Maze

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Abstract Controlled local delivery of antibiotics has been shown to reduce periodontopathic micro‐organisms with minimal side‐effects. Clinical studies in our laboratory have shown that 25% tetracycline HCl delivered from poly(D,L‐lactide/glycolide) film strips (25 TTC‐PLGA) released therapeutic concentrations of tetracycline for 10 days. The present pilot study compared the intracrevicular delivery of 25% tetracycline HCl incorporated in these biodegradable film strips to scaling and root planing (SRP) in 10 adult periodontitis patients, who in spite of therapy and regular supportive periodontal treatment (SPT), continued to possess 5 bleeding periodontal pockets at least 5 mm deep. Sites were randomly selected to receive the following treatments: (1) 25 TTC‐PLGA, (2) control strips without TTC (PLGA), (3) SRP, and (4) untreated control. Film‐strip retention was augmented with a suture/cement technique, followed by strip removal after 2 weeks. Clinical parameters and subgingival bacterial morphotypes (darkfield analysis) were evaluated over time (0, 2, 4, 8, 12, 26 weeks). Results indicated that, compared to baseline, 25 TTC‐PLGA film strips caused significant (p < 0.01): (1) probing depth reduction for 26 weeks, (2) a clinical attachment level gain for 12 weeks. (3) lower %S of spirochetes for 4 weeks and motile rods for 8 weeks (p < 0.05), and (4) an accompanying increase in cocci for 4 weeks. In the scaled and root planed sites, probing depth was the only finding that demonstrated a significant change from baseline (p < 0.01). Controls and PLGA showed isolated reductions in probing depth and % of motile organisms. From these findings, applications of intracrevicular 25 TTC‐PLGA, when compared to scaling and root planing, appears to have an enhanced antibacterial effect and a similar clinical effect in SPT patients. The results of this study indicate further investigation of 25 TTC‐PLGA film strips should be undertaken using more subjects and sophisticated microbiological and clinical measurements.

Original languageEnglish (US)
Pages (from-to)860-867
Number of pages8
JournalJournal of Clinical Periodontology
Volume22
Issue number11
DOIs
StatePublished - Nov 1995

Fingerprint

Tetracycline
Root Planing
Periodontal Pocket
Therapeutics
Suture Techniques
Chronic Periodontitis
Spirochaetales
poly(lactide)
Hemorrhage
Anti-Bacterial Agents
polylactic acid-polyglycolic acid copolymer

Keywords

  • biodegradable films
  • periodontal treatment
  • periodontitis
  • subgingival medications
  • tetracycline

ASJC Scopus subject areas

  • Periodontics

Cite this

Response to intracrevicular controlled delivery of 25% tetracycline from poly(lactide/glycolide) film strips in SPT patients. / Maze, G. I.; Reinhardt, Richard A; Agarwal, R. K.; Dyer, J. K.; Robinson, D. H.; DuBois, L. M.; Tussing, Gerald James; Maze, C. R.

In: Journal of Clinical Periodontology, Vol. 22, No. 11, 11.1995, p. 860-867.

Research output: Contribution to journalArticle

Maze, G. I. ; Reinhardt, Richard A ; Agarwal, R. K. ; Dyer, J. K. ; Robinson, D. H. ; DuBois, L. M. ; Tussing, Gerald James ; Maze, C. R. / Response to intracrevicular controlled delivery of 25% tetracycline from poly(lactide/glycolide) film strips in SPT patients. In: Journal of Clinical Periodontology. 1995 ; Vol. 22, No. 11. pp. 860-867.
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abstract = "Abstract Controlled local delivery of antibiotics has been shown to reduce periodontopathic micro‐organisms with minimal side‐effects. Clinical studies in our laboratory have shown that 25{\%} tetracycline HCl delivered from poly(D,L‐lactide/glycolide) film strips (25 TTC‐PLGA) released therapeutic concentrations of tetracycline for 10 days. The present pilot study compared the intracrevicular delivery of 25{\%} tetracycline HCl incorporated in these biodegradable film strips to scaling and root planing (SRP) in 10 adult periodontitis patients, who in spite of therapy and regular supportive periodontal treatment (SPT), continued to possess 5 bleeding periodontal pockets at least 5 mm deep. Sites were randomly selected to receive the following treatments: (1) 25 TTC‐PLGA, (2) control strips without TTC (PLGA), (3) SRP, and (4) untreated control. Film‐strip retention was augmented with a suture/cement technique, followed by strip removal after 2 weeks. Clinical parameters and subgingival bacterial morphotypes (darkfield analysis) were evaluated over time (0, 2, 4, 8, 12, 26 weeks). Results indicated that, compared to baseline, 25 TTC‐PLGA film strips caused significant (p < 0.01): (1) probing depth reduction for 26 weeks, (2) a clinical attachment level gain for 12 weeks. (3) lower {\%}S of spirochetes for 4 weeks and motile rods for 8 weeks (p < 0.05), and (4) an accompanying increase in cocci for 4 weeks. In the scaled and root planed sites, probing depth was the only finding that demonstrated a significant change from baseline (p < 0.01). Controls and PLGA showed isolated reductions in probing depth and {\%} of motile organisms. From these findings, applications of intracrevicular 25 TTC‐PLGA, when compared to scaling and root planing, appears to have an enhanced antibacterial effect and a similar clinical effect in SPT patients. The results of this study indicate further investigation of 25 TTC‐PLGA film strips should be undertaken using more subjects and sophisticated microbiological and clinical measurements.",
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AU - Maze, G. I.

AU - Reinhardt, Richard A

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AU - Dyer, J. K.

AU - Robinson, D. H.

AU - DuBois, L. M.

AU - Tussing, Gerald James

AU - Maze, C. R.

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N2 - Abstract Controlled local delivery of antibiotics has been shown to reduce periodontopathic micro‐organisms with minimal side‐effects. Clinical studies in our laboratory have shown that 25% tetracycline HCl delivered from poly(D,L‐lactide/glycolide) film strips (25 TTC‐PLGA) released therapeutic concentrations of tetracycline for 10 days. The present pilot study compared the intracrevicular delivery of 25% tetracycline HCl incorporated in these biodegradable film strips to scaling and root planing (SRP) in 10 adult periodontitis patients, who in spite of therapy and regular supportive periodontal treatment (SPT), continued to possess 5 bleeding periodontal pockets at least 5 mm deep. Sites were randomly selected to receive the following treatments: (1) 25 TTC‐PLGA, (2) control strips without TTC (PLGA), (3) SRP, and (4) untreated control. Film‐strip retention was augmented with a suture/cement technique, followed by strip removal after 2 weeks. Clinical parameters and subgingival bacterial morphotypes (darkfield analysis) were evaluated over time (0, 2, 4, 8, 12, 26 weeks). Results indicated that, compared to baseline, 25 TTC‐PLGA film strips caused significant (p < 0.01): (1) probing depth reduction for 26 weeks, (2) a clinical attachment level gain for 12 weeks. (3) lower %S of spirochetes for 4 weeks and motile rods for 8 weeks (p < 0.05), and (4) an accompanying increase in cocci for 4 weeks. In the scaled and root planed sites, probing depth was the only finding that demonstrated a significant change from baseline (p < 0.01). Controls and PLGA showed isolated reductions in probing depth and % of motile organisms. From these findings, applications of intracrevicular 25 TTC‐PLGA, when compared to scaling and root planing, appears to have an enhanced antibacterial effect and a similar clinical effect in SPT patients. The results of this study indicate further investigation of 25 TTC‐PLGA film strips should be undertaken using more subjects and sophisticated microbiological and clinical measurements.

AB - Abstract Controlled local delivery of antibiotics has been shown to reduce periodontopathic micro‐organisms with minimal side‐effects. Clinical studies in our laboratory have shown that 25% tetracycline HCl delivered from poly(D,L‐lactide/glycolide) film strips (25 TTC‐PLGA) released therapeutic concentrations of tetracycline for 10 days. The present pilot study compared the intracrevicular delivery of 25% tetracycline HCl incorporated in these biodegradable film strips to scaling and root planing (SRP) in 10 adult periodontitis patients, who in spite of therapy and regular supportive periodontal treatment (SPT), continued to possess 5 bleeding periodontal pockets at least 5 mm deep. Sites were randomly selected to receive the following treatments: (1) 25 TTC‐PLGA, (2) control strips without TTC (PLGA), (3) SRP, and (4) untreated control. Film‐strip retention was augmented with a suture/cement technique, followed by strip removal after 2 weeks. Clinical parameters and subgingival bacterial morphotypes (darkfield analysis) were evaluated over time (0, 2, 4, 8, 12, 26 weeks). Results indicated that, compared to baseline, 25 TTC‐PLGA film strips caused significant (p < 0.01): (1) probing depth reduction for 26 weeks, (2) a clinical attachment level gain for 12 weeks. (3) lower %S of spirochetes for 4 weeks and motile rods for 8 weeks (p < 0.05), and (4) an accompanying increase in cocci for 4 weeks. In the scaled and root planed sites, probing depth was the only finding that demonstrated a significant change from baseline (p < 0.01). Controls and PLGA showed isolated reductions in probing depth and % of motile organisms. From these findings, applications of intracrevicular 25 TTC‐PLGA, when compared to scaling and root planing, appears to have an enhanced antibacterial effect and a similar clinical effect in SPT patients. The results of this study indicate further investigation of 25 TTC‐PLGA film strips should be undertaken using more subjects and sophisticated microbiological and clinical measurements.

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