Response to Fungal Dysbiosis by Gut-Resident CX3CR1 + Mononuclear Phagocytes Aggravates Allergic Airway Disease

Xin Li, Irina Leonardi, Alexa Semon, Itai Doron, Iris H. Gao, Gregory Garbès Putzel, Youngjun Kim, Hiroki Kabata, David Artis, William D. Fiers, Amanda Ramer-Tait, Iliyan D. Iliev

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

How mycobiota influence immunity in gut distal sites is not well understood. Li et al. developed protocols for gut-targeted depletion of phagocytes and mycobiota-free mice to investigate the influence of fungi on gut-lung crosstalk. They reveal that intestinal phagocytes sense fungal dysbiosis and mediate gut-lung-directed immunity to aggravate allergic airway disease.

Original languageEnglish (US)
Pages (from-to)847-856.e4
JournalCell Host and Microbe
Volume24
Issue number6
DOIs
StatePublished - Dec 12 2018

Fingerprint

Dysbiosis
Phagocytes
Immunity
Lung
Fungi

Keywords

  • CX3CR1 mononuclear phagocytes
  • fungi
  • gut-lung axis
  • mycobiome
  • mycobiota dysbiosis

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology

Cite this

Response to Fungal Dysbiosis by Gut-Resident CX3CR1 + Mononuclear Phagocytes Aggravates Allergic Airway Disease . / Li, Xin; Leonardi, Irina; Semon, Alexa; Doron, Itai; Gao, Iris H.; Putzel, Gregory Garbès; Kim, Youngjun; Kabata, Hiroki; Artis, David; Fiers, William D.; Ramer-Tait, Amanda; Iliev, Iliyan D.

In: Cell Host and Microbe, Vol. 24, No. 6, 12.12.2018, p. 847-856.e4.

Research output: Contribution to journalArticle

Li, X, Leonardi, I, Semon, A, Doron, I, Gao, IH, Putzel, GG, Kim, Y, Kabata, H, Artis, D, Fiers, WD, Ramer-Tait, A & Iliev, ID 2018, ' Response to Fungal Dysbiosis by Gut-Resident CX3CR1 + Mononuclear Phagocytes Aggravates Allergic Airway Disease ', Cell Host and Microbe, vol. 24, no. 6, pp. 847-856.e4. https://doi.org/10.1016/j.chom.2018.11.003
Li, Xin ; Leonardi, Irina ; Semon, Alexa ; Doron, Itai ; Gao, Iris H. ; Putzel, Gregory Garbès ; Kim, Youngjun ; Kabata, Hiroki ; Artis, David ; Fiers, William D. ; Ramer-Tait, Amanda ; Iliev, Iliyan D. / Response to Fungal Dysbiosis by Gut-Resident CX3CR1 + Mononuclear Phagocytes Aggravates Allergic Airway Disease In: Cell Host and Microbe. 2018 ; Vol. 24, No. 6. pp. 847-856.e4.
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