Response to comments of Peter G. Mantle

Gary Schwartz, Richard A. Manderville, Annie Pfohl-Leszkowicz

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The apparently high yield of testis tumors (25%) in rats exposed long-term to Ochratoxin A (OTA) is uninterpretable without data on tumor yield in unexposed rats. Conversely, our demonstration that prenatal exposure to OTA induces DNA adducts in the testes of newborn mice and the absence of these adducts in the testes of mice not exposed prenatally to OTA, is evidence for the presumptive carcinogenicity of OTA in the testis. Together with recent data showing that prenatal exposure to OTA depresses expression of DMRT1, a tumor suppressor gene in the testis, our findings suggest that OTA may be a cause of testicular cancer.

Original languageEnglish (US)
Pages (from-to)2337-2339
Number of pages3
JournalToxins
Volume2
Issue number10
DOIs
StatePublished - Oct 1 2010

Fingerprint

Testis
Tumors
Rats
DNA Adducts
Testicular Neoplasms
Tumor Suppressor Genes
ochratoxin A
Neoplasms
Demonstrations
Genes

Keywords

  • Dna adduct
  • Ochratoxin
  • Testicular cancer

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Schwartz, G., Manderville, R. A., & Pfohl-Leszkowicz, A. (2010). Response to comments of Peter G. Mantle. Toxins, 2(10), 2337-2339. https://doi.org/10.3390/toxins2102337

Response to comments of Peter G. Mantle. / Schwartz, Gary; Manderville, Richard A.; Pfohl-Leszkowicz, Annie.

In: Toxins, Vol. 2, No. 10, 01.10.2010, p. 2337-2339.

Research output: Contribution to journalArticle

Schwartz, G, Manderville, RA & Pfohl-Leszkowicz, A 2010, 'Response to comments of Peter G. Mantle', Toxins, vol. 2, no. 10, pp. 2337-2339. https://doi.org/10.3390/toxins2102337
Schwartz G, Manderville RA, Pfohl-Leszkowicz A. Response to comments of Peter G. Mantle. Toxins. 2010 Oct 1;2(10):2337-2339. https://doi.org/10.3390/toxins2102337
Schwartz, Gary ; Manderville, Richard A. ; Pfohl-Leszkowicz, Annie. / Response to comments of Peter G. Mantle. In: Toxins. 2010 ; Vol. 2, No. 10. pp. 2337-2339.
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