Response of tumors to therapy studied by31p magnetic resonance spectroscopy

G. S. Karczmar, D. J. Meyerhoff, A. Speder, F. Valone, M. Wilkinson, N. Shine, Michael D Boska, M. W. Weiner

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Magnetic resonance (MR) methods have been used to study the metabolic and vascular response of model tumors to tumor necrosis factor (TNF). Magnetic resonance measurements demonstrated acute reductions in tumor blood flow, measured from tumor uptake of D20, and in tumor adenosine triphosphate (ATP), measured by 31P magnetic resonance spectroscopy (MRS) following administration of TNF. The decrease in ATP generally followed reduction in tumor blood flow, and therefore was probably due to ischemia caused by damage to tumor vasculature. Superficial human tumors have been studied by MRS to characterize their 3IP spectra, and to measure metabolic changes during therapy. The ratio of the intensities of the phosphomonoester (PME) and ATP resonances (PME/ATP) was much higher in tumors than in the normal tissue displaced by the tumors. During therapy, decreases in PME/ATP were detected that paralleled, but did not anticipate, decreases in tumor size. In some cases, a transient increase in PME/ATP was detected during therapy, which did not correlate with changes in tumor size, and which may reflect stimulation of cell growth in some tumor zones.

Original languageEnglish (US)
Pages (from-to)1020-1023
Number of pages4
JournalInvestigative Radiology
Volume24
Issue number12
DOIs
StatePublished - Jan 1 1989

Fingerprint

Magnetic Resonance Spectroscopy
Neoplasms
Adenosine Triphosphate
Therapeutics
Tumor Necrosis Factor-alpha
Blood Vessels
Ischemia
Growth

Keywords

  • P MRS
  • Tumor blood flow
  • Tumor metabolism
  • Tumor necrosis factor
  • Tumor therapy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Karczmar, G. S., Meyerhoff, D. J., Speder, A., Valone, F., Wilkinson, M., Shine, N., ... Weiner, M. W. (1989). Response of tumors to therapy studied by31p magnetic resonance spectroscopy. Investigative Radiology, 24(12), 1020-1023. https://doi.org/10.1097/00004424-198912000-00022

Response of tumors to therapy studied by31p magnetic resonance spectroscopy. / Karczmar, G. S.; Meyerhoff, D. J.; Speder, A.; Valone, F.; Wilkinson, M.; Shine, N.; Boska, Michael D; Weiner, M. W.

In: Investigative Radiology, Vol. 24, No. 12, 01.01.1989, p. 1020-1023.

Research output: Contribution to journalArticle

Karczmar, GS, Meyerhoff, DJ, Speder, A, Valone, F, Wilkinson, M, Shine, N, Boska, MD & Weiner, MW 1989, 'Response of tumors to therapy studied by31p magnetic resonance spectroscopy', Investigative Radiology, vol. 24, no. 12, pp. 1020-1023. https://doi.org/10.1097/00004424-198912000-00022
Karczmar GS, Meyerhoff DJ, Speder A, Valone F, Wilkinson M, Shine N et al. Response of tumors to therapy studied by31p magnetic resonance spectroscopy. Investigative Radiology. 1989 Jan 1;24(12):1020-1023. https://doi.org/10.1097/00004424-198912000-00022
Karczmar, G. S. ; Meyerhoff, D. J. ; Speder, A. ; Valone, F. ; Wilkinson, M. ; Shine, N. ; Boska, Michael D ; Weiner, M. W. / Response of tumors to therapy studied by31p magnetic resonance spectroscopy. In: Investigative Radiology. 1989 ; Vol. 24, No. 12. pp. 1020-1023.
@article{d6b192dbfb4341da825f57e365a19726,
title = "Response of tumors to therapy studied by31p magnetic resonance spectroscopy",
abstract = "Magnetic resonance (MR) methods have been used to study the metabolic and vascular response of model tumors to tumor necrosis factor (TNF). Magnetic resonance measurements demonstrated acute reductions in tumor blood flow, measured from tumor uptake of D20, and in tumor adenosine triphosphate (ATP), measured by 31P magnetic resonance spectroscopy (MRS) following administration of TNF. The decrease in ATP generally followed reduction in tumor blood flow, and therefore was probably due to ischemia caused by damage to tumor vasculature. Superficial human tumors have been studied by MRS to characterize their 3IP spectra, and to measure metabolic changes during therapy. The ratio of the intensities of the phosphomonoester (PME) and ATP resonances (PME/ATP) was much higher in tumors than in the normal tissue displaced by the tumors. During therapy, decreases in PME/ATP were detected that paralleled, but did not anticipate, decreases in tumor size. In some cases, a transient increase in PME/ATP was detected during therapy, which did not correlate with changes in tumor size, and which may reflect stimulation of cell growth in some tumor zones.",
keywords = "P MRS, Tumor blood flow, Tumor metabolism, Tumor necrosis factor, Tumor therapy",
author = "Karczmar, {G. S.} and Meyerhoff, {D. J.} and A. Speder and F. Valone and M. Wilkinson and N. Shine and Boska, {Michael D} and Weiner, {M. W.}",
year = "1989",
month = "1",
day = "1",
doi = "10.1097/00004424-198912000-00022",
language = "English (US)",
volume = "24",
pages = "1020--1023",
journal = "Investigative Radiology",
issn = "0020-9996",
publisher = "Lippincott Williams and Wilkins",
number = "12",

}

TY - JOUR

T1 - Response of tumors to therapy studied by31p magnetic resonance spectroscopy

AU - Karczmar, G. S.

AU - Meyerhoff, D. J.

AU - Speder, A.

AU - Valone, F.

AU - Wilkinson, M.

AU - Shine, N.

AU - Boska, Michael D

AU - Weiner, M. W.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - Magnetic resonance (MR) methods have been used to study the metabolic and vascular response of model tumors to tumor necrosis factor (TNF). Magnetic resonance measurements demonstrated acute reductions in tumor blood flow, measured from tumor uptake of D20, and in tumor adenosine triphosphate (ATP), measured by 31P magnetic resonance spectroscopy (MRS) following administration of TNF. The decrease in ATP generally followed reduction in tumor blood flow, and therefore was probably due to ischemia caused by damage to tumor vasculature. Superficial human tumors have been studied by MRS to characterize their 3IP spectra, and to measure metabolic changes during therapy. The ratio of the intensities of the phosphomonoester (PME) and ATP resonances (PME/ATP) was much higher in tumors than in the normal tissue displaced by the tumors. During therapy, decreases in PME/ATP were detected that paralleled, but did not anticipate, decreases in tumor size. In some cases, a transient increase in PME/ATP was detected during therapy, which did not correlate with changes in tumor size, and which may reflect stimulation of cell growth in some tumor zones.

AB - Magnetic resonance (MR) methods have been used to study the metabolic and vascular response of model tumors to tumor necrosis factor (TNF). Magnetic resonance measurements demonstrated acute reductions in tumor blood flow, measured from tumor uptake of D20, and in tumor adenosine triphosphate (ATP), measured by 31P magnetic resonance spectroscopy (MRS) following administration of TNF. The decrease in ATP generally followed reduction in tumor blood flow, and therefore was probably due to ischemia caused by damage to tumor vasculature. Superficial human tumors have been studied by MRS to characterize their 3IP spectra, and to measure metabolic changes during therapy. The ratio of the intensities of the phosphomonoester (PME) and ATP resonances (PME/ATP) was much higher in tumors than in the normal tissue displaced by the tumors. During therapy, decreases in PME/ATP were detected that paralleled, but did not anticipate, decreases in tumor size. In some cases, a transient increase in PME/ATP was detected during therapy, which did not correlate with changes in tumor size, and which may reflect stimulation of cell growth in some tumor zones.

KW - P MRS

KW - Tumor blood flow

KW - Tumor metabolism

KW - Tumor necrosis factor

KW - Tumor therapy

UR - http://www.scopus.com/inward/record.url?scp=0024827565&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024827565&partnerID=8YFLogxK

U2 - 10.1097/00004424-198912000-00022

DO - 10.1097/00004424-198912000-00022

M3 - Article

VL - 24

SP - 1020

EP - 1023

JO - Investigative Radiology

JF - Investigative Radiology

SN - 0020-9996

IS - 12

ER -