Response of conventionally raised weanling pigs to experimental infection with a virulent strain of porcine parvovirus.

T. T. Brown, Prem S Paul, W. L. Mengeling

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Conventionally raised 6-week-old pigs were inoculated intranaslly and orally with porcine parvovirus. The pigs remained clinically normal for up to 17 days. They were viremic between 2 and 6 days after inoculation and had detectable hemagglutination-inhibiting titers to porcine parvovirus at 5 or 6 days after inoculation. Virus was isolated from multiple tissues of pigs killed between 3 and 17 days after inoculation. Viral antigen was demonstrated mainly in lymphoid tissues of these pigs. Gross and microscopic examination of tissues failed to reveal any notable pathologic changes. The numbers of thymus- and bone marrow-derived lymphocytes did not differ significantly in inoculated and noninoculated control pigs, and the response of peripheral blood lymphocytes to selected mitogens was not altered by infection.

Original languageEnglish (US)
Pages (from-to)1221-1224
Number of pages4
JournalAmerican journal of veterinary research
Volume41
Issue number8
StatePublished - Aug 1 1980

Fingerprint

Porcine Parvovirus
Ungulate protoparvovirus 1
weanlings
Swine
swine
Infection
infection
lymphocytes
Lymphocytes
Viral Antigens
viral antigens
Hemagglutination
Lymphoid Tissue
hemagglutination
Mitogens
bone marrow
Thymus Gland
Bone Marrow
virulent strains
Viruses

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Response of conventionally raised weanling pigs to experimental infection with a virulent strain of porcine parvovirus. / Brown, T. T.; Paul, Prem S; Mengeling, W. L.

In: American journal of veterinary research, Vol. 41, No. 8, 01.08.1980, p. 1221-1224.

Research output: Contribution to journalArticle

@article{45560a75374944ffb2666a5cb63e5334,
title = "Response of conventionally raised weanling pigs to experimental infection with a virulent strain of porcine parvovirus.",
abstract = "Conventionally raised 6-week-old pigs were inoculated intranaslly and orally with porcine parvovirus. The pigs remained clinically normal for up to 17 days. They were viremic between 2 and 6 days after inoculation and had detectable hemagglutination-inhibiting titers to porcine parvovirus at 5 or 6 days after inoculation. Virus was isolated from multiple tissues of pigs killed between 3 and 17 days after inoculation. Viral antigen was demonstrated mainly in lymphoid tissues of these pigs. Gross and microscopic examination of tissues failed to reveal any notable pathologic changes. The numbers of thymus- and bone marrow-derived lymphocytes did not differ significantly in inoculated and noninoculated control pigs, and the response of peripheral blood lymphocytes to selected mitogens was not altered by infection.",
author = "Brown, {T. T.} and Paul, {Prem S} and Mengeling, {W. L.}",
year = "1980",
month = "8",
day = "1",
language = "English (US)",
volume = "41",
pages = "1221--1224",
journal = "American Journal of Veterinary Research",
issn = "0002-9645",
publisher = "American Veterinary Medical Association",
number = "8",

}

TY - JOUR

T1 - Response of conventionally raised weanling pigs to experimental infection with a virulent strain of porcine parvovirus.

AU - Brown, T. T.

AU - Paul, Prem S

AU - Mengeling, W. L.

PY - 1980/8/1

Y1 - 1980/8/1

N2 - Conventionally raised 6-week-old pigs were inoculated intranaslly and orally with porcine parvovirus. The pigs remained clinically normal for up to 17 days. They were viremic between 2 and 6 days after inoculation and had detectable hemagglutination-inhibiting titers to porcine parvovirus at 5 or 6 days after inoculation. Virus was isolated from multiple tissues of pigs killed between 3 and 17 days after inoculation. Viral antigen was demonstrated mainly in lymphoid tissues of these pigs. Gross and microscopic examination of tissues failed to reveal any notable pathologic changes. The numbers of thymus- and bone marrow-derived lymphocytes did not differ significantly in inoculated and noninoculated control pigs, and the response of peripheral blood lymphocytes to selected mitogens was not altered by infection.

AB - Conventionally raised 6-week-old pigs were inoculated intranaslly and orally with porcine parvovirus. The pigs remained clinically normal for up to 17 days. They were viremic between 2 and 6 days after inoculation and had detectable hemagglutination-inhibiting titers to porcine parvovirus at 5 or 6 days after inoculation. Virus was isolated from multiple tissues of pigs killed between 3 and 17 days after inoculation. Viral antigen was demonstrated mainly in lymphoid tissues of these pigs. Gross and microscopic examination of tissues failed to reveal any notable pathologic changes. The numbers of thymus- and bone marrow-derived lymphocytes did not differ significantly in inoculated and noninoculated control pigs, and the response of peripheral blood lymphocytes to selected mitogens was not altered by infection.

UR - http://www.scopus.com/inward/record.url?scp=0019052953&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019052953&partnerID=8YFLogxK

M3 - Article

VL - 41

SP - 1221

EP - 1224

JO - American Journal of Veterinary Research

JF - American Journal of Veterinary Research

SN - 0002-9645

IS - 8

ER -