Resource-driven changes to host population stability alter the evolution of virulence and transmission

Jessica L. Hite, Clayton E. Cressler

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

What drives the evolution of parasite life-history traits? Recent studies suggest that linking within- and between-host processes can provide key insight into both disease dynamics and parasite evolution. Still, it remains difficult to understand how to pinpoint the critical factors connecting these cross-scale feedbacks, particularly under non-equilibrium conditions; many natural host populations inherently fluctuate and parasites themselves can strongly alter the stability of host populations. Here, we develop a general model framework that mechanistically links resources to parasite evolution across a gradient of stable and unstable conditions. First, we dynamically link resources and between-host processes (host density, stability, transmission) to virulence evolution, using a ‘non-nested’ model. Then, we consider a ‘nested’ model where population-level processes (trans-mission and virulence) depend on resource-driven changes to individual-level (within-host) processes (energetics, immune function, parasite pro-duction). Contrary to ‘non-nested’ model predictions, the ‘nested’ model reveals complex effects of host population dynamics on parasite evolution, including regions of evolutionary bistability; evolution can push parasites towards strongly or weakly stabilizing strategies. This bistability results from dynamic feedbacks between resource-driven changes to host density, host immune function and parasite production. Together, these results highlight how cross-scale feedbacks can provide key insights into the structuring role of parasites and parasite evolution. This article is part of the theme issue ‘Anthropogenic resource subsidies and host–parasite dynamics in wildlife’.

Original languageEnglish (US)
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume373
Issue number1745
DOIs
StatePublished - May 5 2018

Fingerprint

Virulence
Parasites
virulence
parasites
Population
Feedback
Population dynamics
Population Dynamics
subsidies
wildlife
population dynamics
life history
prediction

Keywords

  • Adaptive dynamics
  • Consumer-resource
  • Nested models
  • Parasite evolution
  • Transmission
  • Virulence

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

@article{a38cde9bc19c4327a8d95021c7e23ddd,
title = "Resource-driven changes to host population stability alter the evolution of virulence and transmission",
abstract = "What drives the evolution of parasite life-history traits? Recent studies suggest that linking within- and between-host processes can provide key insight into both disease dynamics and parasite evolution. Still, it remains difficult to understand how to pinpoint the critical factors connecting these cross-scale feedbacks, particularly under non-equilibrium conditions; many natural host populations inherently fluctuate and parasites themselves can strongly alter the stability of host populations. Here, we develop a general model framework that mechanistically links resources to parasite evolution across a gradient of stable and unstable conditions. First, we dynamically link resources and between-host processes (host density, stability, transmission) to virulence evolution, using a ‘non-nested’ model. Then, we consider a ‘nested’ model where population-level processes (trans-mission and virulence) depend on resource-driven changes to individual-level (within-host) processes (energetics, immune function, parasite pro-duction). Contrary to ‘non-nested’ model predictions, the ‘nested’ model reveals complex effects of host population dynamics on parasite evolution, including regions of evolutionary bistability; evolution can push parasites towards strongly or weakly stabilizing strategies. This bistability results from dynamic feedbacks between resource-driven changes to host density, host immune function and parasite production. Together, these results highlight how cross-scale feedbacks can provide key insights into the structuring role of parasites and parasite evolution. This article is part of the theme issue ‘Anthropogenic resource subsidies and host–parasite dynamics in wildlife’.",
keywords = "Adaptive dynamics, Consumer-resource, Nested models, Parasite evolution, Transmission, Virulence",
author = "Hite, {Jessica L.} and Cressler, {Clayton E.}",
year = "2018",
month = "5",
day = "5",
doi = "10.1098/rstb.2017.0087",
language = "English (US)",
volume = "373",
journal = "Philosophical Transactions of the Royal Society B: Biological Sciences",
issn = "0800-4622",
publisher = "Royal Society of London",
number = "1745",

}

TY - JOUR

T1 - Resource-driven changes to host population stability alter the evolution of virulence and transmission

AU - Hite, Jessica L.

AU - Cressler, Clayton E.

PY - 2018/5/5

Y1 - 2018/5/5

N2 - What drives the evolution of parasite life-history traits? Recent studies suggest that linking within- and between-host processes can provide key insight into both disease dynamics and parasite evolution. Still, it remains difficult to understand how to pinpoint the critical factors connecting these cross-scale feedbacks, particularly under non-equilibrium conditions; many natural host populations inherently fluctuate and parasites themselves can strongly alter the stability of host populations. Here, we develop a general model framework that mechanistically links resources to parasite evolution across a gradient of stable and unstable conditions. First, we dynamically link resources and between-host processes (host density, stability, transmission) to virulence evolution, using a ‘non-nested’ model. Then, we consider a ‘nested’ model where population-level processes (trans-mission and virulence) depend on resource-driven changes to individual-level (within-host) processes (energetics, immune function, parasite pro-duction). Contrary to ‘non-nested’ model predictions, the ‘nested’ model reveals complex effects of host population dynamics on parasite evolution, including regions of evolutionary bistability; evolution can push parasites towards strongly or weakly stabilizing strategies. This bistability results from dynamic feedbacks between resource-driven changes to host density, host immune function and parasite production. Together, these results highlight how cross-scale feedbacks can provide key insights into the structuring role of parasites and parasite evolution. This article is part of the theme issue ‘Anthropogenic resource subsidies and host–parasite dynamics in wildlife’.

AB - What drives the evolution of parasite life-history traits? Recent studies suggest that linking within- and between-host processes can provide key insight into both disease dynamics and parasite evolution. Still, it remains difficult to understand how to pinpoint the critical factors connecting these cross-scale feedbacks, particularly under non-equilibrium conditions; many natural host populations inherently fluctuate and parasites themselves can strongly alter the stability of host populations. Here, we develop a general model framework that mechanistically links resources to parasite evolution across a gradient of stable and unstable conditions. First, we dynamically link resources and between-host processes (host density, stability, transmission) to virulence evolution, using a ‘non-nested’ model. Then, we consider a ‘nested’ model where population-level processes (trans-mission and virulence) depend on resource-driven changes to individual-level (within-host) processes (energetics, immune function, parasite pro-duction). Contrary to ‘non-nested’ model predictions, the ‘nested’ model reveals complex effects of host population dynamics on parasite evolution, including regions of evolutionary bistability; evolution can push parasites towards strongly or weakly stabilizing strategies. This bistability results from dynamic feedbacks between resource-driven changes to host density, host immune function and parasite production. Together, these results highlight how cross-scale feedbacks can provide key insights into the structuring role of parasites and parasite evolution. This article is part of the theme issue ‘Anthropogenic resource subsidies and host–parasite dynamics in wildlife’.

KW - Adaptive dynamics

KW - Consumer-resource

KW - Nested models

KW - Parasite evolution

KW - Transmission

KW - Virulence

UR - http://www.scopus.com/inward/record.url?scp=85044078460&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044078460&partnerID=8YFLogxK

U2 - 10.1098/rstb.2017.0087

DO - 10.1098/rstb.2017.0087

M3 - Article

C2 - 29531142

AN - SCOPUS:85044078460

VL - 373

JO - Philosophical Transactions of the Royal Society B: Biological Sciences

JF - Philosophical Transactions of the Royal Society B: Biological Sciences

SN - 0800-4622

IS - 1745

ER -