Resistance of male Sprague-Dawley rats to sucrose-induced obesity

Effects of 18-methoxycoronaridine

Olha Taraschenko, Isabelle M. Maisonneuve, Stanley D. Glick

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Evidence suggests that the development of obesity in males and females might be mediated by distinct mechanisms, warranting different treatment approaches. In previous studies from this laboratory, a high sucrose diet induced excessive weight gain in female Sprague-Dawley rats and administration of a selective antagonist of α3β4 nicotinic receptors, 18-methoxycoronaridine (18-MC), prevented this form of obesity. In the present study similar parameters were studied in male rats by using an identical experimental protocol. The effects of repeated administration of 18-MC on body weight gain, deposition of fat, consummatory behavior and biochemical markers of obesity in male rats were also assessed. In contrast to females, males consuming ad libitum quantities of sucrose solution (30%) in combination with normal chow did not become obese; they did not gain excessive weight nor show excessive fat deposition. Repeated administration of 18-MC (20. mg/kg, i.p.) attenuated weight gain in both sucrose-consuming and control animals without altering food or fluid intake. The present results indicate that males and females are differentially responsive to high carbohydrate-diet obesity. Such gender disparities could be secondary to sex-specific alterations in cholinergic mechanisms of feeding and body weight regulation.

Original languageEnglish (US)
Pages (from-to)126-131
Number of pages6
JournalPhysiology and Behavior
Volume102
Issue number2
DOIs
StatePublished - Feb 1 2011

Fingerprint

Sprague Dawley Rats
Sucrose
Obesity
Weight Gain
Consummatory Behavior
Fats
Body Weight
Diet
Nicotinic Receptors
Cholinergic Agents
Biomarkers
Carbohydrates
18-methoxycoronaridine
Food

Keywords

  • Nicotinic receptors
  • Sex difference
  • Sucrose diet
  • Weight gain

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Cite this

Resistance of male Sprague-Dawley rats to sucrose-induced obesity : Effects of 18-methoxycoronaridine. / Taraschenko, Olha; Maisonneuve, Isabelle M.; Glick, Stanley D.

In: Physiology and Behavior, Vol. 102, No. 2, 01.02.2011, p. 126-131.

Research output: Contribution to journalArticle

Taraschenko, Olha ; Maisonneuve, Isabelle M. ; Glick, Stanley D. / Resistance of male Sprague-Dawley rats to sucrose-induced obesity : Effects of 18-methoxycoronaridine. In: Physiology and Behavior. 2011 ; Vol. 102, No. 2. pp. 126-131.
@article{2b0fbf97bdc94937aaa2cb95e76d5e1d,
title = "Resistance of male Sprague-Dawley rats to sucrose-induced obesity: Effects of 18-methoxycoronaridine",
abstract = "Evidence suggests that the development of obesity in males and females might be mediated by distinct mechanisms, warranting different treatment approaches. In previous studies from this laboratory, a high sucrose diet induced excessive weight gain in female Sprague-Dawley rats and administration of a selective antagonist of α3β4 nicotinic receptors, 18-methoxycoronaridine (18-MC), prevented this form of obesity. In the present study similar parameters were studied in male rats by using an identical experimental protocol. The effects of repeated administration of 18-MC on body weight gain, deposition of fat, consummatory behavior and biochemical markers of obesity in male rats were also assessed. In contrast to females, males consuming ad libitum quantities of sucrose solution (30{\%}) in combination with normal chow did not become obese; they did not gain excessive weight nor show excessive fat deposition. Repeated administration of 18-MC (20. mg/kg, i.p.) attenuated weight gain in both sucrose-consuming and control animals without altering food or fluid intake. The present results indicate that males and females are differentially responsive to high carbohydrate-diet obesity. Such gender disparities could be secondary to sex-specific alterations in cholinergic mechanisms of feeding and body weight regulation.",
keywords = "Nicotinic receptors, Sex difference, Sucrose diet, Weight gain",
author = "Olha Taraschenko and Maisonneuve, {Isabelle M.} and Glick, {Stanley D.}",
year = "2011",
month = "2",
day = "1",
doi = "10.1016/j.physbeh.2010.10.010",
language = "English (US)",
volume = "102",
pages = "126--131",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Resistance of male Sprague-Dawley rats to sucrose-induced obesity

T2 - Effects of 18-methoxycoronaridine

AU - Taraschenko, Olha

AU - Maisonneuve, Isabelle M.

AU - Glick, Stanley D.

PY - 2011/2/1

Y1 - 2011/2/1

N2 - Evidence suggests that the development of obesity in males and females might be mediated by distinct mechanisms, warranting different treatment approaches. In previous studies from this laboratory, a high sucrose diet induced excessive weight gain in female Sprague-Dawley rats and administration of a selective antagonist of α3β4 nicotinic receptors, 18-methoxycoronaridine (18-MC), prevented this form of obesity. In the present study similar parameters were studied in male rats by using an identical experimental protocol. The effects of repeated administration of 18-MC on body weight gain, deposition of fat, consummatory behavior and biochemical markers of obesity in male rats were also assessed. In contrast to females, males consuming ad libitum quantities of sucrose solution (30%) in combination with normal chow did not become obese; they did not gain excessive weight nor show excessive fat deposition. Repeated administration of 18-MC (20. mg/kg, i.p.) attenuated weight gain in both sucrose-consuming and control animals without altering food or fluid intake. The present results indicate that males and females are differentially responsive to high carbohydrate-diet obesity. Such gender disparities could be secondary to sex-specific alterations in cholinergic mechanisms of feeding and body weight regulation.

AB - Evidence suggests that the development of obesity in males and females might be mediated by distinct mechanisms, warranting different treatment approaches. In previous studies from this laboratory, a high sucrose diet induced excessive weight gain in female Sprague-Dawley rats and administration of a selective antagonist of α3β4 nicotinic receptors, 18-methoxycoronaridine (18-MC), prevented this form of obesity. In the present study similar parameters were studied in male rats by using an identical experimental protocol. The effects of repeated administration of 18-MC on body weight gain, deposition of fat, consummatory behavior and biochemical markers of obesity in male rats were also assessed. In contrast to females, males consuming ad libitum quantities of sucrose solution (30%) in combination with normal chow did not become obese; they did not gain excessive weight nor show excessive fat deposition. Repeated administration of 18-MC (20. mg/kg, i.p.) attenuated weight gain in both sucrose-consuming and control animals without altering food or fluid intake. The present results indicate that males and females are differentially responsive to high carbohydrate-diet obesity. Such gender disparities could be secondary to sex-specific alterations in cholinergic mechanisms of feeding and body weight regulation.

KW - Nicotinic receptors

KW - Sex difference

KW - Sucrose diet

KW - Weight gain

UR - http://www.scopus.com/inward/record.url?scp=78649363936&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78649363936&partnerID=8YFLogxK

U2 - 10.1016/j.physbeh.2010.10.010

DO - 10.1016/j.physbeh.2010.10.010

M3 - Article

VL - 102

SP - 126

EP - 131

JO - Physiology and Behavior

JF - Physiology and Behavior

SN - 0031-9384

IS - 2

ER -