Reproductive hormones after pancreas transplantation

Lynn R Mack, Tanaporn Ratanasuwan, John P. Leone, Suzanne A. Miller, Elizabeth R. Lyden, Judi M. Erickson, Jennifer Lynn Larsen

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background. Reproductive hormone function after pancreas transplantation (PTX) is unknown as it has not been studied. Methods. We prospectively studied PTX recipients to determine changes in reproductive hormones after PTX. Testosterone or estradiol, leutinizing hormone, follicle stimulating hormone, and prolactin were determined before and 1 year after PTX in 23 patients (10 women, 13 men) followed for more than 1 year after PTX. Of these, 11 received simultaneous kidney-PTX; 8 PTX only; and 4, PTX after kidney. Average age was 38.4±1.6 years and average duration of diabetes was 24.5±1.3 years. Nine (four women, five men) patients had been on dialysis pre-PTX. Sixteen of 23 patients were treated with cyclosporine and seven with FK-506 along with prednisone and azathioprine post-PTX. Results. Mean testosterone in men was normal pre- and post-PTX. Two men had secondary hypogonadism pre-PTX with resolution in one and persistence in the other post-PTX. Five of the ten women had evidence of hypogonadism pre-PTX: three had primary hypogonadism and two had secondary hypogonadism. Post-PTX, 7 of 10 women had abnormal reproductive hormones: 4 had primary hypogonadism, 2 had secondary hypogonadism, and 1 developed hyperestrogenemia with elevated estradiol (482 pg/ml) and leutinizing hormone (41 IU/liter). Mean prednisone dose and cyclosporine trough level were higher in the women than the men (P<0.05). No cases of secondary hypogonadism that developed or resolved post-PTX were related to changes in prolactin, renal function, or hyperglycemia. Conclusions. Women are more likely than men to have reproductive hormone abnormalities pre- and post-PTX and the causes may be multiple.

Original languageEnglish (US)
Pages (from-to)1180-1183
Number of pages4
JournalTransplantation
Volume70
Issue number8
DOIs
StatePublished - Oct 27 2000

Fingerprint

Pancreas Transplantation
Hypogonadism
Hormones
Prednisone
Kidney
Prolactin
Cyclosporine
Testosterone
Estradiol
Azathioprine
Follicle Stimulating Hormone
Tacrolimus
Hyperglycemia
Dialysis

ASJC Scopus subject areas

  • Transplantation

Cite this

Mack, L. R., Ratanasuwan, T., Leone, J. P., Miller, S. A., Lyden, E. R., Erickson, J. M., & Larsen, J. L. (2000). Reproductive hormones after pancreas transplantation. Transplantation, 70(8), 1180-1183. https://doi.org/10.1097/00007890-200010270-00009

Reproductive hormones after pancreas transplantation. / Mack, Lynn R; Ratanasuwan, Tanaporn; Leone, John P.; Miller, Suzanne A.; Lyden, Elizabeth R.; Erickson, Judi M.; Larsen, Jennifer Lynn.

In: Transplantation, Vol. 70, No. 8, 27.10.2000, p. 1180-1183.

Research output: Contribution to journalArticle

Mack, LR, Ratanasuwan, T, Leone, JP, Miller, SA, Lyden, ER, Erickson, JM & Larsen, JL 2000, 'Reproductive hormones after pancreas transplantation', Transplantation, vol. 70, no. 8, pp. 1180-1183. https://doi.org/10.1097/00007890-200010270-00009
Mack LR, Ratanasuwan T, Leone JP, Miller SA, Lyden ER, Erickson JM et al. Reproductive hormones after pancreas transplantation. Transplantation. 2000 Oct 27;70(8):1180-1183. https://doi.org/10.1097/00007890-200010270-00009
Mack, Lynn R ; Ratanasuwan, Tanaporn ; Leone, John P. ; Miller, Suzanne A. ; Lyden, Elizabeth R. ; Erickson, Judi M. ; Larsen, Jennifer Lynn. / Reproductive hormones after pancreas transplantation. In: Transplantation. 2000 ; Vol. 70, No. 8. pp. 1180-1183.
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abstract = "Background. Reproductive hormone function after pancreas transplantation (PTX) is unknown as it has not been studied. Methods. We prospectively studied PTX recipients to determine changes in reproductive hormones after PTX. Testosterone or estradiol, leutinizing hormone, follicle stimulating hormone, and prolactin were determined before and 1 year after PTX in 23 patients (10 women, 13 men) followed for more than 1 year after PTX. Of these, 11 received simultaneous kidney-PTX; 8 PTX only; and 4, PTX after kidney. Average age was 38.4±1.6 years and average duration of diabetes was 24.5±1.3 years. Nine (four women, five men) patients had been on dialysis pre-PTX. Sixteen of 23 patients were treated with cyclosporine and seven with FK-506 along with prednisone and azathioprine post-PTX. Results. Mean testosterone in men was normal pre- and post-PTX. Two men had secondary hypogonadism pre-PTX with resolution in one and persistence in the other post-PTX. Five of the ten women had evidence of hypogonadism pre-PTX: three had primary hypogonadism and two had secondary hypogonadism. Post-PTX, 7 of 10 women had abnormal reproductive hormones: 4 had primary hypogonadism, 2 had secondary hypogonadism, and 1 developed hyperestrogenemia with elevated estradiol (482 pg/ml) and leutinizing hormone (41 IU/liter). Mean prednisone dose and cyclosporine trough level were higher in the women than the men (P<0.05). No cases of secondary hypogonadism that developed or resolved post-PTX were related to changes in prolactin, renal function, or hyperglycemia. Conclusions. Women are more likely than men to have reproductive hormone abnormalities pre- and post-PTX and the causes may be multiple.",
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AU - Mack, Lynn R

AU - Ratanasuwan, Tanaporn

AU - Leone, John P.

AU - Miller, Suzanne A.

AU - Lyden, Elizabeth R.

AU - Erickson, Judi M.

AU - Larsen, Jennifer Lynn

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N2 - Background. Reproductive hormone function after pancreas transplantation (PTX) is unknown as it has not been studied. Methods. We prospectively studied PTX recipients to determine changes in reproductive hormones after PTX. Testosterone or estradiol, leutinizing hormone, follicle stimulating hormone, and prolactin were determined before and 1 year after PTX in 23 patients (10 women, 13 men) followed for more than 1 year after PTX. Of these, 11 received simultaneous kidney-PTX; 8 PTX only; and 4, PTX after kidney. Average age was 38.4±1.6 years and average duration of diabetes was 24.5±1.3 years. Nine (four women, five men) patients had been on dialysis pre-PTX. Sixteen of 23 patients were treated with cyclosporine and seven with FK-506 along with prednisone and azathioprine post-PTX. Results. Mean testosterone in men was normal pre- and post-PTX. Two men had secondary hypogonadism pre-PTX with resolution in one and persistence in the other post-PTX. Five of the ten women had evidence of hypogonadism pre-PTX: three had primary hypogonadism and two had secondary hypogonadism. Post-PTX, 7 of 10 women had abnormal reproductive hormones: 4 had primary hypogonadism, 2 had secondary hypogonadism, and 1 developed hyperestrogenemia with elevated estradiol (482 pg/ml) and leutinizing hormone (41 IU/liter). Mean prednisone dose and cyclosporine trough level were higher in the women than the men (P<0.05). No cases of secondary hypogonadism that developed or resolved post-PTX were related to changes in prolactin, renal function, or hyperglycemia. Conclusions. Women are more likely than men to have reproductive hormone abnormalities pre- and post-PTX and the causes may be multiple.

AB - Background. Reproductive hormone function after pancreas transplantation (PTX) is unknown as it has not been studied. Methods. We prospectively studied PTX recipients to determine changes in reproductive hormones after PTX. Testosterone or estradiol, leutinizing hormone, follicle stimulating hormone, and prolactin were determined before and 1 year after PTX in 23 patients (10 women, 13 men) followed for more than 1 year after PTX. Of these, 11 received simultaneous kidney-PTX; 8 PTX only; and 4, PTX after kidney. Average age was 38.4±1.6 years and average duration of diabetes was 24.5±1.3 years. Nine (four women, five men) patients had been on dialysis pre-PTX. Sixteen of 23 patients were treated with cyclosporine and seven with FK-506 along with prednisone and azathioprine post-PTX. Results. Mean testosterone in men was normal pre- and post-PTX. Two men had secondary hypogonadism pre-PTX with resolution in one and persistence in the other post-PTX. Five of the ten women had evidence of hypogonadism pre-PTX: three had primary hypogonadism and two had secondary hypogonadism. Post-PTX, 7 of 10 women had abnormal reproductive hormones: 4 had primary hypogonadism, 2 had secondary hypogonadism, and 1 developed hyperestrogenemia with elevated estradiol (482 pg/ml) and leutinizing hormone (41 IU/liter). Mean prednisone dose and cyclosporine trough level were higher in the women than the men (P<0.05). No cases of secondary hypogonadism that developed or resolved post-PTX were related to changes in prolactin, renal function, or hyperglycemia. Conclusions. Women are more likely than men to have reproductive hormone abnormalities pre- and post-PTX and the causes may be multiple.

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