Repating developmental expression of G-Hox 7, a novel homeobox-containing gene in the chicken

Hiroaki R. Suzuki, Babu J. Padanilam, Emilia Vitale, Francesco Ramirez, Michael Solursh

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Here we describe the isolation and characterization of a new chicken homeobox-containing gene, G-Hox 7, which is related to Drosophila msh. The deduced amino acid sequence of the cDNA shows greater than 96% homology to the homeo domain of other vertebrate msh-like genes. As for other species, the amino and carboxy termini of the protein are, however, greatly divergent when compared phylogenetically. In situ hybridization studies revealed the early and widespread expression of G-Hox 7 during chick development. This includes its expression in the primitive streak and extraembryonic cells undergoing epiboly, and its expression along the neural axis, including the forebrain. Expression was also observed in the neural crest, neural crest-derived facial and branchial structures, the otocyst, limb, and heart valves. This widespread and recurrent expression of the transcript suggests that the gene may play an essential role at multiple sites during the initiation of new developmental pathways.

Original languageEnglish (US)
Pages (from-to)375-388
Number of pages14
JournalDevelopmental Biology
Volume148
Issue number1
DOIs
StatePublished - Nov 1991

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Neural Crest
Homeobox Genes
Chickens
Primitive Streak
Heart Valves
Prosencephalon
Genes
Drosophila
In Situ Hybridization
Vertebrates
Amino Acid Sequence
Extremities
Complementary DNA
Proteins

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Cite this

Repating developmental expression of G-Hox 7, a novel homeobox-containing gene in the chicken. / Suzuki, Hiroaki R.; Padanilam, Babu J.; Vitale, Emilia; Ramirez, Francesco; Solursh, Michael.

In: Developmental Biology, Vol. 148, No. 1, 11.1991, p. 375-388.

Research output: Contribution to journalArticle

Suzuki, Hiroaki R. ; Padanilam, Babu J. ; Vitale, Emilia ; Ramirez, Francesco ; Solursh, Michael. / Repating developmental expression of G-Hox 7, a novel homeobox-containing gene in the chicken. In: Developmental Biology. 1991 ; Vol. 148, No. 1. pp. 375-388.
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