Renal pelvic neoplasms and atypical urothelium in patients with end-stage analgesic nephropathy

I. Blohme, Sonny Lennart Johansson

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

In a series of 772 renal transplant patients, 84 had analgesic nephropathy (AN). Four of then had renal pelvic carcinoma. The incidence of atypical urothelial changes of the renal pelvis was studied in 56 AN patients, the majority nephrectomized before or shortly after the renal transplantation. Urothelial atypia, usually bilaterally, was found in 27 patients. Multiple sections resulted in an even higher incidence (8/9). No atypical changes were found in normal kidneys or in end-stage diseased kidneys with other diseases, or in chronically rejected renal allografts. These findings further strengthen the association between intake of phenacetin-containing analgesics and the development of renal pelvic tumors. Patients with end-stage analgesic nephropathy are a high-risk group for developing urinary tract tumors and should be subjected to endoscopic and cytologic surveillance. After renal transplantation, prophylactic bilateral nephroureterectomy is advocated.

Original languageEnglish (US)
Pages (from-to)671-675
Number of pages5
JournalKidney International
Volume20
Issue number5
DOIs
StatePublished - Jan 1 1981

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Pelvic Neoplasms
Urothelium
Kidney Neoplasms
Analgesics
Kidney
Kidney Transplantation
Phenacetin
Kidney Pelvis
Incidence
Urinary Tract
Chronic Kidney Failure
Allografts
Neoplasms
Carcinoma
Transplants

ASJC Scopus subject areas

  • Nephrology

Cite this

Renal pelvic neoplasms and atypical urothelium in patients with end-stage analgesic nephropathy. / Blohme, I.; Johansson, Sonny Lennart.

In: Kidney International, Vol. 20, No. 5, 01.01.1981, p. 671-675.

Research output: Contribution to journalArticle

Blohme, I. ; Johansson, Sonny Lennart. / Renal pelvic neoplasms and atypical urothelium in patients with end-stage analgesic nephropathy. In: Kidney International. 1981 ; Vol. 20, No. 5. pp. 671-675.
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