Renal nerves drive interstitial fibrogenesis in obstructive nephropathy

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

The signals that drive fibrogenesis after an initiating insult to the kidney are incompletely understood. Here, we report that renal nerve stimulation after ureteral obstruction is the primary profibrotic signal and that renal denervation prevents both fibrogenesis and the inflammatory cascade. Local infusion of neural factors, norepinephrine, and calcitonin gene-related peptide (CGRP) in denervated kidneys mimicked the fibrotic response observed in innervated obstructed kidneys. Norepinephrine and CGRP act through the α2-adrenergic receptor and CGRP receptor, respectively, because blocking these receptors prevented fibrosis, the inflammatory response, and tubular cell death. In tubular epithelial cells, both norepinephrine and CGRP induced apoptosis and the release of profibrotic factors capable of stimulating the differentiation of fibroblasts to myofibroblasts. In conclusion, these data suggest that nerve-derived signaling molecules may drive renal fibrosis and that their suppression may be a therapeutic approach to fibrosis prevention.

Original languageEnglish (US)
Pages (from-to)229-242
Number of pages14
JournalJournal of the American Society of Nephrology
Volume24
Issue number2
DOIs
StatePublished - Jan 31 2013

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Kidney
Calcitonin Gene-Related Peptide
Norepinephrine
Fibrosis
Calcitonin Gene-Related Peptide Receptors
Leukemia Inhibitory Factor
Ureteral Obstruction
Myofibroblasts
Denervation
Adrenergic Receptors
Cell Death
Fibroblasts
Epithelial Cells
Apoptosis
Therapeutics

ASJC Scopus subject areas

  • Nephrology

Cite this

Renal nerves drive interstitial fibrogenesis in obstructive nephropathy. / Kim, Jinu; Padanilam, Babu J.

In: Journal of the American Society of Nephrology, Vol. 24, No. 2, 31.01.2013, p. 229-242.

Research output: Contribution to journalArticle

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