Reliability and reproducibility of spectral and time domain optical coherence tomography images before and after correction for patients with age-related macular degeneration

Yasir J. Sepah, Mohammad A. Sadiq, Aymen Rashid, Roomasa Channa, Elham Hatef, Diana V. Do, Quan Dong Nguyen

Research output: Contribution to journalArticle

Abstract

Purpose: To evaluate the reproducibility and reliability of optical coherence tomography scans obtained using the time domain (TD-OCT) Stratus TM OCT, and the Spectral Domain (SD-OCT) Spectralis TM and Cirrus TM OCT devices before and after manual correction in eyes with either Neovascular (NV-AMD) or Non-Neovascular (NNV-AMD) age-related macular degeneration. Design: Prospective observational study. Methods: Setting: University-based retina practice. Patients: Thirty-six patients (50 eyes) with NV-AMD or NNV-AMD. Procedure: OCT scans were taken simultaneously using one TD-OCT and two SD-OCT devices. Main Outcome Measures: Macular thickness measurements were assessed before and after correction of the algorithm by constructing Bland-Altman plots for agreement and calculating intraclass correlation coefficients (ICCs) and coefficients of repeatability (COR) to evaluate intraclass repeatability. Results: Spectralis had the highest number of images needing manual correction. All machines had high ICCs, with Spectralis having the highest. Also, Bland-Altman plots indicated that there was low agreement between Cirrus™ and Stratus™, Spectralis™ and Stratus™, while there was good agreement between the Cirrus™ and Spectralis™. The CORs were lowest for Spectralis TM and similar and higher for Cirrus TM and Stratus TM. Agreement, CORs, and ICCs generally improved after manual correction, but only minimally. Conclusion: Agreement is low between devices, except between both SD-OCT machines. Manual correction tends to improve results.

Original languageEnglish (US)
JournalF1000Research
Volume2
DOIs
StatePublished - Mar 5 2015

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Thickness measurement
Optical tomography
Optical Coherence Tomography
Macular Degeneration
Equipment and Supplies
Observational Studies
Retina
Outcome Assessment (Health Care)
Prospective Studies

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Reliability and reproducibility of spectral and time domain optical coherence tomography images before and after correction for patients with age-related macular degeneration. / Sepah, Yasir J.; Sadiq, Mohammad A.; Rashid, Aymen; Channa, Roomasa; Hatef, Elham; Do, Diana V.; Nguyen, Quan Dong.

In: F1000Research, Vol. 2, 05.03.2015.

Research output: Contribution to journalArticle

Sepah, Yasir J. ; Sadiq, Mohammad A. ; Rashid, Aymen ; Channa, Roomasa ; Hatef, Elham ; Do, Diana V. ; Nguyen, Quan Dong. / Reliability and reproducibility of spectral and time domain optical coherence tomography images before and after correction for patients with age-related macular degeneration. In: F1000Research. 2015 ; Vol. 2.
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N2 - Purpose: To evaluate the reproducibility and reliability of optical coherence tomography scans obtained using the time domain (TD-OCT) Stratus TM OCT, and the Spectral Domain (SD-OCT) Spectralis TM and Cirrus TM OCT devices before and after manual correction in eyes with either Neovascular (NV-AMD) or Non-Neovascular (NNV-AMD) age-related macular degeneration. Design: Prospective observational study. Methods: Setting: University-based retina practice. Patients: Thirty-six patients (50 eyes) with NV-AMD or NNV-AMD. Procedure: OCT scans were taken simultaneously using one TD-OCT and two SD-OCT devices. Main Outcome Measures: Macular thickness measurements were assessed before and after correction of the algorithm by constructing Bland-Altman plots for agreement and calculating intraclass correlation coefficients (ICCs) and coefficients of repeatability (COR) to evaluate intraclass repeatability. Results: Spectralis had the highest number of images needing manual correction. All machines had high ICCs, with Spectralis having the highest. Also, Bland-Altman plots indicated that there was low agreement between Cirrus™ and Stratus™, Spectralis™ and Stratus™, while there was good agreement between the Cirrus™ and Spectralis™. The CORs were lowest for Spectralis TM and similar and higher for Cirrus TM and Stratus TM. Agreement, CORs, and ICCs generally improved after manual correction, but only minimally. Conclusion: Agreement is low between devices, except between both SD-OCT machines. Manual correction tends to improve results.

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