Relevance of Blood Vessel Networks in Blast-Induced Traumatic Brain Injury

Yi Hua, Shengmao Lin, Linxia Gu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Cerebral vasculature is a complex network that circulates blood through the brain. However, the role of this networking effect in brain dynamics has seldom been inspected. This work is to study the effects of blood vessel networks on dynamic responses of the brain under blast loading. Voronoi tessellations were implemented to represent the network of blood vessels in the brain. The brain dynamics in terms of maximum principal strain (MPS), shear strain (SS), and intracranial pressure (ICP) were monitored and compared. Results show that blood vessel networks significantly affected brain responses. The increased MPS and SS were observed within the brain embedded with vessel networks, which did not exist in the case without blood vessel networks. It is interesting to observe that the alternation of the ICP response was minimal. Moreover, the vessel diameter and density also affected brain dynamics in both MPS and SS measures. This work sheds light on the role of cerebral vasculature in blast-induced traumatic brain injury.

Original languageEnglish (US)
Article number928236
JournalComputational and Mathematical Methods in Medicine
Volume2015
DOIs
StatePublished - Jan 1 2015

Fingerprint

Blast
Blood Vessels
Blood vessels
Brain
Shear strain
Intracranial Pressure
Vessel
Voronoi Tessellation
Relevance
Traumatic Brain Injury
Alternation
Complex networks
Dynamic Response
Networking
Complex Networks
Dynamic response
Blood

ASJC Scopus subject areas

  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Applied Mathematics

Cite this

Relevance of Blood Vessel Networks in Blast-Induced Traumatic Brain Injury. / Hua, Yi; Lin, Shengmao; Gu, Linxia.

In: Computational and Mathematical Methods in Medicine, Vol. 2015, 928236, 01.01.2015.

Research output: Contribution to journalArticle

@article{5345fb338c4e4a589a00a8a02d2aacca,
title = "Relevance of Blood Vessel Networks in Blast-Induced Traumatic Brain Injury",
abstract = "Cerebral vasculature is a complex network that circulates blood through the brain. However, the role of this networking effect in brain dynamics has seldom been inspected. This work is to study the effects of blood vessel networks on dynamic responses of the brain under blast loading. Voronoi tessellations were implemented to represent the network of blood vessels in the brain. The brain dynamics in terms of maximum principal strain (MPS), shear strain (SS), and intracranial pressure (ICP) were monitored and compared. Results show that blood vessel networks significantly affected brain responses. The increased MPS and SS were observed within the brain embedded with vessel networks, which did not exist in the case without blood vessel networks. It is interesting to observe that the alternation of the ICP response was minimal. Moreover, the vessel diameter and density also affected brain dynamics in both MPS and SS measures. This work sheds light on the role of cerebral vasculature in blast-induced traumatic brain injury.",
author = "Yi Hua and Shengmao Lin and Linxia Gu",
year = "2015",
month = "1",
day = "1",
doi = "10.1155/2015/928236",
language = "English (US)",
volume = "2015",
journal = "Computational and Mathematical Methods in Medicine",
issn = "1748-670X",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Relevance of Blood Vessel Networks in Blast-Induced Traumatic Brain Injury

AU - Hua, Yi

AU - Lin, Shengmao

AU - Gu, Linxia

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Cerebral vasculature is a complex network that circulates blood through the brain. However, the role of this networking effect in brain dynamics has seldom been inspected. This work is to study the effects of blood vessel networks on dynamic responses of the brain under blast loading. Voronoi tessellations were implemented to represent the network of blood vessels in the brain. The brain dynamics in terms of maximum principal strain (MPS), shear strain (SS), and intracranial pressure (ICP) were monitored and compared. Results show that blood vessel networks significantly affected brain responses. The increased MPS and SS were observed within the brain embedded with vessel networks, which did not exist in the case without blood vessel networks. It is interesting to observe that the alternation of the ICP response was minimal. Moreover, the vessel diameter and density also affected brain dynamics in both MPS and SS measures. This work sheds light on the role of cerebral vasculature in blast-induced traumatic brain injury.

AB - Cerebral vasculature is a complex network that circulates blood through the brain. However, the role of this networking effect in brain dynamics has seldom been inspected. This work is to study the effects of blood vessel networks on dynamic responses of the brain under blast loading. Voronoi tessellations were implemented to represent the network of blood vessels in the brain. The brain dynamics in terms of maximum principal strain (MPS), shear strain (SS), and intracranial pressure (ICP) were monitored and compared. Results show that blood vessel networks significantly affected brain responses. The increased MPS and SS were observed within the brain embedded with vessel networks, which did not exist in the case without blood vessel networks. It is interesting to observe that the alternation of the ICP response was minimal. Moreover, the vessel diameter and density also affected brain dynamics in both MPS and SS measures. This work sheds light on the role of cerebral vasculature in blast-induced traumatic brain injury.

UR - http://www.scopus.com/inward/record.url?scp=84944224734&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944224734&partnerID=8YFLogxK

U2 - 10.1155/2015/928236

DO - 10.1155/2015/928236

M3 - Article

C2 - 26495036

AN - SCOPUS:84944224734

VL - 2015

JO - Computational and Mathematical Methods in Medicine

JF - Computational and Mathematical Methods in Medicine

SN - 1748-670X

M1 - 928236

ER -