Relaxin reduces fibrosis in models of progressive and established hepatic fibrosis

Robert G Bennett, Dean G. Heimann, Dean J. Tuma

Research output: Chapter in Book/Report/Conference proceedingConference contribution

13 Citations (Scopus)

Abstract

The effect of relaxin administration before (prevention) or after (treatment) the establishment of hepatic fibrosis in a mouse model was examined. In the prevention study, relaxin reduced collagen and smooth muscle actin content and significantly reduced serum levels of the liver enzymes alanine aminotransferase and aspartate aminotransferase. In the treatment study, administration of relaxin for 1 week reduced collagen and smooth muscle actin but not liver enzyme levels. Relaxin administered for 2 weeks had no significant effect. In conclusion, the data suggest that relaxin treatment before fibrosis can reduce collagen and improve liver function but that there is little effect of short-term relaxin treatment after fibrosis is established.

Original languageEnglish (US)
Title of host publicationRelaxin and Related Peptides Fifth International Conference
PublisherBlackwell Publishing Inc.
Pages348-349
Number of pages2
ISBN (Print)9781573317214
DOIs
StatePublished - Jan 1 2009

Publication series

NameAnnals of the New York Academy of Sciences
Volume1160
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Fingerprint

Relaxin
Fibrosis
Liver
Collagen
Smooth Muscle
Muscle
Actins
Enzymes
Aspartate Aminotransferases
Alanine Transaminase
Serum

Keywords

  • Collagen
  • Hepatic fibrosis
  • Liver
  • Relaxin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Bennett, R. G., Heimann, D. G., & Tuma, D. J. (2009). Relaxin reduces fibrosis in models of progressive and established hepatic fibrosis. In Relaxin and Related Peptides Fifth International Conference (pp. 348-349). (Annals of the New York Academy of Sciences; Vol. 1160). Blackwell Publishing Inc.. https://doi.org/10.1111/j.1749-6632.2008.03783.x

Relaxin reduces fibrosis in models of progressive and established hepatic fibrosis. / Bennett, Robert G; Heimann, Dean G.; Tuma, Dean J.

Relaxin and Related Peptides Fifth International Conference. Blackwell Publishing Inc., 2009. p. 348-349 (Annals of the New York Academy of Sciences; Vol. 1160).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Bennett, RG, Heimann, DG & Tuma, DJ 2009, Relaxin reduces fibrosis in models of progressive and established hepatic fibrosis. in Relaxin and Related Peptides Fifth International Conference. Annals of the New York Academy of Sciences, vol. 1160, Blackwell Publishing Inc., pp. 348-349. https://doi.org/10.1111/j.1749-6632.2008.03783.x
Bennett RG, Heimann DG, Tuma DJ. Relaxin reduces fibrosis in models of progressive and established hepatic fibrosis. In Relaxin and Related Peptides Fifth International Conference. Blackwell Publishing Inc. 2009. p. 348-349. (Annals of the New York Academy of Sciences). https://doi.org/10.1111/j.1749-6632.2008.03783.x
Bennett, Robert G ; Heimann, Dean G. ; Tuma, Dean J. / Relaxin reduces fibrosis in models of progressive and established hepatic fibrosis. Relaxin and Related Peptides Fifth International Conference. Blackwell Publishing Inc., 2009. pp. 348-349 (Annals of the New York Academy of Sciences).
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