Relaxin family peptide receptor 1 activation stimulates peroxisome proliferator-activated receptor gamma

Sudhir Singh, Robert G Bennett

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

Relaxin (RLX) has antifibrotic effects in a number of tissues. Many of these effects are similar to those induced by the activators of peroxisome proliferator-activated receptor gamma (PPARγ), raising the possibility that a mechanism for RLX's antifibrotic effects may involve activation of the PPARγ pathway. This study investigated the effect of RLX on PPARs and their mechanism of upregulation. It shows that RLX stimulates ligand-independent PPAR activation in a dose-dependent manner. The combined effect of RLX and PPARγ agonists was superadditive, suggesting that both agents might be used together for an increased antifibrotic effect. RLX caused increased expression of the PPARγ target genes CD36 and LXRα. RLX's effect was mimicked by forskolin and partially blocked by pertussis toxin, suggesting that RLX works through a cAMP/protein kinase A pathway to activate PPARγ. A better understanding of this pathway might help in the amelioration of fibrotic diseases.

Original languageEnglish (US)
Title of host publicationRelaxin and Related Peptides Fifth International Conference
PublisherBlackwell Publishing Inc.
Pages112-116
Number of pages5
ISBN (Print)9781573317214
DOIs
StatePublished - Apr 2009

Publication series

NameAnnals of the New York Academy of Sciences
Volume1160
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Fingerprint

Relaxin
Peptide Receptors
PPAR gamma
Chemical activation
Peroxisome Proliferator-Activated Receptors
Pertussis Toxin
Colforsin
Cyclic AMP-Dependent Protein Kinases
Up-Regulation
Genes
Tissue
Ligands

Keywords

  • Insulin-like peptides (Insl3)
  • Peroxisome proliferator response element (PPRE)
  • Peroxisome proliferator-activated receptor (PPAR)
  • Relaxin family peptide receptor1 (RXFP1)
  • Relaxin-3 (Rlx-3)

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Singh, S., & Bennett, R. G. (2009). Relaxin family peptide receptor 1 activation stimulates peroxisome proliferator-activated receptor gamma. In Relaxin and Related Peptides Fifth International Conference (pp. 112-116). (Annals of the New York Academy of Sciences; Vol. 1160). Blackwell Publishing Inc.. https://doi.org/10.1111/j.1749-6632.2008.03808.x

Relaxin family peptide receptor 1 activation stimulates peroxisome proliferator-activated receptor gamma. / Singh, Sudhir; Bennett, Robert G.

Relaxin and Related Peptides Fifth International Conference. Blackwell Publishing Inc., 2009. p. 112-116 (Annals of the New York Academy of Sciences; Vol. 1160).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Singh, S & Bennett, RG 2009, Relaxin family peptide receptor 1 activation stimulates peroxisome proliferator-activated receptor gamma. in Relaxin and Related Peptides Fifth International Conference. Annals of the New York Academy of Sciences, vol. 1160, Blackwell Publishing Inc., pp. 112-116. https://doi.org/10.1111/j.1749-6632.2008.03808.x
Singh S, Bennett RG. Relaxin family peptide receptor 1 activation stimulates peroxisome proliferator-activated receptor gamma. In Relaxin and Related Peptides Fifth International Conference. Blackwell Publishing Inc. 2009. p. 112-116. (Annals of the New York Academy of Sciences). https://doi.org/10.1111/j.1749-6632.2008.03808.x
Singh, Sudhir ; Bennett, Robert G. / Relaxin family peptide receptor 1 activation stimulates peroxisome proliferator-activated receptor gamma. Relaxin and Related Peptides Fifth International Conference. Blackwell Publishing Inc., 2009. pp. 112-116 (Annals of the New York Academy of Sciences).
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