Relative frequency of non-Hodgkin lymphoma subtypes in selected centres in North Africa, the middle east and India: A review of 971 cases

Anamarija M. Perry, Jacques Diebold, Bharat N. Nathwani, Kenneth A. Maclennan, Hans K. Müller-Hermelink, Martin Bast, Eugene Boilesen, James Olen Armitage, Dennis D. Weisenburger

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Abstract

Comparative data regarding the distribution of non-Hodgkin lymphoma (NHL) subtypes in North Africa, the Middle East and India (NAF/ME/IN) is scarce in the literature. In this study, we evaluated the relative frequencies of NHL subtypes in this region. Five expert haematopathologists classified 971 consecutive cases of newly-diagnosed NHL from five countries in NAF/ME/IN. After review, 890 cases (91·7%) were confirmed to be NHL and compared to 399 cases from North America (NA). The male-to-female ratio was significantly higher in NAF/ME/IN (1·8) compared to NA (1·1; P< 0·05). The median ages of patients with low-grade (LG) and high-grade (HG) B-NHL in NAF/ME/IN (56 and 52 years, respectively) were significantly lower than in NA (64 and 68 years, respectively). In NAF/ME/IN, a significantly lower proportion of LG B-NHL (28·4%) and a higher proportion of HG B-NHL (58·4%) were found compared to NA (56·1% and 34·3%, respectively). Diffuse large B-cell lymphoma was more common in NAF/ME/IN (49·4%) compared to NA (29·3%), whereas follicular lymphoma was less common in NAF/ME/IN (12·4%) than in NA (33·6%). In conclusion, we found significant differences in NHL subtypes and clinical features between NAF/ME/IN and NA. Epidemiological studies are needed to better understand the pathobiology of these differences.

Original languageEnglish (US)
Pages (from-to)699-708
Number of pages10
JournalBritish Journal of Haematology
Volume172
Issue number5
DOIs
StatePublished - Mar 1 2016

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Northern Africa
Middle East
Non-Hodgkin's Lymphoma
North America
India
Follicular Lymphoma
Lymphoma, Large B-Cell, Diffuse
Epidemiologic Studies

Keywords

  • Epidemiology
  • Middle East
  • Non-Hodgkin lymphoma
  • North Africa

ASJC Scopus subject areas

  • Hematology

Cite this

Perry, A. M., Diebold, J., Nathwani, B. N., Maclennan, K. A., Müller-Hermelink, H. K., Bast, M., ... Weisenburger, D. D. (2016). Relative frequency of non-Hodgkin lymphoma subtypes in selected centres in North Africa, the middle east and India: A review of 971 cases. British Journal of Haematology, 172(5), 699-708. https://doi.org/10.1111/bjh.13876

Relative frequency of non-Hodgkin lymphoma subtypes in selected centres in North Africa, the middle east and India : A review of 971 cases. / Perry, Anamarija M.; Diebold, Jacques; Nathwani, Bharat N.; Maclennan, Kenneth A.; Müller-Hermelink, Hans K.; Bast, Martin; Boilesen, Eugene; Armitage, James Olen; Weisenburger, Dennis D.

In: British Journal of Haematology, Vol. 172, No. 5, 01.03.2016, p. 699-708.

Research output: Contribution to journalArticle

Perry, AM, Diebold, J, Nathwani, BN, Maclennan, KA, Müller-Hermelink, HK, Bast, M, Boilesen, E, Armitage, JO & Weisenburger, DD 2016, 'Relative frequency of non-Hodgkin lymphoma subtypes in selected centres in North Africa, the middle east and India: A review of 971 cases', British Journal of Haematology, vol. 172, no. 5, pp. 699-708. https://doi.org/10.1111/bjh.13876
Perry, Anamarija M. ; Diebold, Jacques ; Nathwani, Bharat N. ; Maclennan, Kenneth A. ; Müller-Hermelink, Hans K. ; Bast, Martin ; Boilesen, Eugene ; Armitage, James Olen ; Weisenburger, Dennis D. / Relative frequency of non-Hodgkin lymphoma subtypes in selected centres in North Africa, the middle east and India : A review of 971 cases. In: British Journal of Haematology. 2016 ; Vol. 172, No. 5. pp. 699-708.
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title = "Relative frequency of non-Hodgkin lymphoma subtypes in selected centres in North Africa, the middle east and India: A review of 971 cases",
abstract = "Comparative data regarding the distribution of non-Hodgkin lymphoma (NHL) subtypes in North Africa, the Middle East and India (NAF/ME/IN) is scarce in the literature. In this study, we evaluated the relative frequencies of NHL subtypes in this region. Five expert haematopathologists classified 971 consecutive cases of newly-diagnosed NHL from five countries in NAF/ME/IN. After review, 890 cases (91·7{\%}) were confirmed to be NHL and compared to 399 cases from North America (NA). The male-to-female ratio was significantly higher in NAF/ME/IN (1·8) compared to NA (1·1; P< 0·05). The median ages of patients with low-grade (LG) and high-grade (HG) B-NHL in NAF/ME/IN (56 and 52 years, respectively) were significantly lower than in NA (64 and 68 years, respectively). In NAF/ME/IN, a significantly lower proportion of LG B-NHL (28·4{\%}) and a higher proportion of HG B-NHL (58·4{\%}) were found compared to NA (56·1{\%} and 34·3{\%}, respectively). Diffuse large B-cell lymphoma was more common in NAF/ME/IN (49·4{\%}) compared to NA (29·3{\%}), whereas follicular lymphoma was less common in NAF/ME/IN (12·4{\%}) than in NA (33·6{\%}). In conclusion, we found significant differences in NHL subtypes and clinical features between NAF/ME/IN and NA. Epidemiological studies are needed to better understand the pathobiology of these differences.",
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AB - Comparative data regarding the distribution of non-Hodgkin lymphoma (NHL) subtypes in North Africa, the Middle East and India (NAF/ME/IN) is scarce in the literature. In this study, we evaluated the relative frequencies of NHL subtypes in this region. Five expert haematopathologists classified 971 consecutive cases of newly-diagnosed NHL from five countries in NAF/ME/IN. After review, 890 cases (91·7%) were confirmed to be NHL and compared to 399 cases from North America (NA). The male-to-female ratio was significantly higher in NAF/ME/IN (1·8) compared to NA (1·1; P< 0·05). The median ages of patients with low-grade (LG) and high-grade (HG) B-NHL in NAF/ME/IN (56 and 52 years, respectively) were significantly lower than in NA (64 and 68 years, respectively). In NAF/ME/IN, a significantly lower proportion of LG B-NHL (28·4%) and a higher proportion of HG B-NHL (58·4%) were found compared to NA (56·1% and 34·3%, respectively). Diffuse large B-cell lymphoma was more common in NAF/ME/IN (49·4%) compared to NA (29·3%), whereas follicular lymphoma was less common in NAF/ME/IN (12·4%) than in NA (33·6%). In conclusion, we found significant differences in NHL subtypes and clinical features between NAF/ME/IN and NA. Epidemiological studies are needed to better understand the pathobiology of these differences.

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