Relative frequency of non-Hodgkin lymphoma subtypes in selected centres in North Africa, the middle east and India: A review of 971 cases

Anamarija M. Perry, Jacques Diebold, Bharat N. Nathwani, Kenneth A. Maclennan, Hans K. Müller-Hermelink, Martin Bast, Eugene Boilesen, James Olen Armitage, Dennis D. Weisenburger

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Abstract

Comparative data regarding the distribution of non-Hodgkin lymphoma (NHL) subtypes in North Africa, the Middle East and India (NAF/ME/IN) is scarce in the literature. In this study, we evaluated the relative frequencies of NHL subtypes in this region. Five expert haematopathologists classified 971 consecutive cases of newly-diagnosed NHL from five countries in NAF/ME/IN. After review, 890 cases (91·7%) were confirmed to be NHL and compared to 399 cases from North America (NA). The male-to-female ratio was significantly higher in NAF/ME/IN (1·8) compared to NA (1·1; P< 0·05). The median ages of patients with low-grade (LG) and high-grade (HG) B-NHL in NAF/ME/IN (56 and 52 years, respectively) were significantly lower than in NA (64 and 68 years, respectively). In NAF/ME/IN, a significantly lower proportion of LG B-NHL (28·4%) and a higher proportion of HG B-NHL (58·4%) were found compared to NA (56·1% and 34·3%, respectively). Diffuse large B-cell lymphoma was more common in NAF/ME/IN (49·4%) compared to NA (29·3%), whereas follicular lymphoma was less common in NAF/ME/IN (12·4%) than in NA (33·6%). In conclusion, we found significant differences in NHL subtypes and clinical features between NAF/ME/IN and NA. Epidemiological studies are needed to better understand the pathobiology of these differences.

Original languageEnglish (US)
Pages (from-to)699-708
Number of pages10
JournalBritish Journal of Haematology
Volume172
Issue number5
DOIs
Publication statusPublished - Mar 1 2016

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Keywords

  • Epidemiology
  • Middle East
  • Non-Hodgkin lymphoma
  • North Africa

ASJC Scopus subject areas

  • Hematology

Cite this

Perry, A. M., Diebold, J., Nathwani, B. N., Maclennan, K. A., Müller-Hermelink, H. K., Bast, M., ... Weisenburger, D. D. (2016). Relative frequency of non-Hodgkin lymphoma subtypes in selected centres in North Africa, the middle east and India: A review of 971 cases. British Journal of Haematology, 172(5), 699-708. https://doi.org/10.1111/bjh.13876