Relationships and differentially expressed genes among pancreatic cancers examined by large-scale serial analysis of gene expression

Byungwoo Ryu, Jessa Jones, Natalie J. Blades, Giovanni Parmigiani, Michael A. Hollingsworth, Ralph H. Hruban, Michael A Hollingsworth

Research output: Contribution to journalArticle

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Abstract

Pancreatic adenocarcinoma is among the most fatal of cancers, in part because of late diagnosis and a lack of effective therapies. Comprehensive studies are needed to better understand and address the cellular mechanisms and pathways of tumorigenesis. Serial analysis of gene expression was used to analyze gene expression profiles of pancreatic cancer cell lines, short-term cultures of normal pancreatic ductal epithelium, and primary pancreatic cancer tissue. A total of 294,920 tags representing 77,746 genes in 10 serial analysis of gene expression libraries were analyzed. A pancreatic cancer cell line (Hs766T) that exhibited a "normoid" profile of gene expression was identified. Several genes that may be involved in the fundamental nature of malignant changes in pancreatic ductal epithelium were suggested from those differentially and highly expressed in pancreatic cancer cells as compared with normal epithelium. Some overexpressed genes, such as S100A4, prostate stem cell antigen, carcinoembryonic antigen-related cell adhesion molecule 6, and mesothelin, suggest potential use as diagnostic markers. Others suggest potential novel therapeutic targets.

Original languageEnglish (US)
Pages (from-to)819-826
Number of pages8
JournalCancer Research
Volume62
Issue number3
StatePublished - Feb 1 2002

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Pancreatic Neoplasms
Gene Expression
Epithelium
Transcriptome
Genes
Cell Line
Delayed Diagnosis
Carcinoembryonic Antigen
Cell Adhesion Molecules
Gene Library
Prostate
Carcinogenesis
Adenocarcinoma
Stem Cells
Antigens
Therapeutics
Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Ryu, B., Jones, J., Blades, N. J., Parmigiani, G., Hollingsworth, M. A., Hruban, R. H., & Hollingsworth, M. A. (2002). Relationships and differentially expressed genes among pancreatic cancers examined by large-scale serial analysis of gene expression. Cancer Research, 62(3), 819-826.

Relationships and differentially expressed genes among pancreatic cancers examined by large-scale serial analysis of gene expression. / Ryu, Byungwoo; Jones, Jessa; Blades, Natalie J.; Parmigiani, Giovanni; Hollingsworth, Michael A.; Hruban, Ralph H.; Hollingsworth, Michael A.

In: Cancer Research, Vol. 62, No. 3, 01.02.2002, p. 819-826.

Research output: Contribution to journalArticle

Ryu, B, Jones, J, Blades, NJ, Parmigiani, G, Hollingsworth, MA, Hruban, RH & Hollingsworth, MA 2002, 'Relationships and differentially expressed genes among pancreatic cancers examined by large-scale serial analysis of gene expression', Cancer Research, vol. 62, no. 3, pp. 819-826.
Ryu B, Jones J, Blades NJ, Parmigiani G, Hollingsworth MA, Hruban RH et al. Relationships and differentially expressed genes among pancreatic cancers examined by large-scale serial analysis of gene expression. Cancer Research. 2002 Feb 1;62(3):819-826.
Ryu, Byungwoo ; Jones, Jessa ; Blades, Natalie J. ; Parmigiani, Giovanni ; Hollingsworth, Michael A. ; Hruban, Ralph H. ; Hollingsworth, Michael A. / Relationships and differentially expressed genes among pancreatic cancers examined by large-scale serial analysis of gene expression. In: Cancer Research. 2002 ; Vol. 62, No. 3. pp. 819-826.
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