Relationship of resting b-type natriuretic peptide level to cardiac work and total physical work capacity in heart failure patients

Joseph F Norman, Bunny Pozehl, Kathleen A. Duncan, Melody A. Hertzog, Ahmed S. Elokda, Steven K. Krueger

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: Plasma B-type natriuretic peptide (BNP) levels obtained at rest have been previously shown to be correlated with the global functional capacity measures of peak oxygen uptake (VO2peak) and the minute ventilation/carbon dioxide (VE/VCO2) slope. The purpose of this study was to assess the relationship of the plasma BNP level to the rate-pressure product (RPP) as an indicator of central or cardiac work capacity. Methods: Twenty-two subjects (12 men), mean age 57 ± 12 years, diagnosed with heart failure (8 ischemic/14 nonischemic) were recruited. All subjects were stable on optimal medical therapy for at least 1 month. Blood samples for BNP level analysis were obtained at rest. Subjects underwent a symptom-limited treadmill exercise test using a ramping protocol while VO2, heart rate (HR), and blood pressure (BP) were monitored. Correlation analyses were conducted to assess the relationship of BNP level to RPP level, VO 2peak, VE/VCO2 slope, end-tidal CO2 pressure (PETCO2), and left ventricular ejection fraction (LVEF). Results: Resting BNP levels were significantly correlated with RPP levels (r = g-'0.69). The BNP level and the RPP level were correlated with VO2peak (r = -'0.63 and r = 0.66, respectively) and VE/VCO2peak slope (r = 0.53 and r =-'0.54, respectively). The RPP level but not the BNP level was correlated with PETCO2 (r = 0.57). Neither BNP nor RPP levels were well correlated with LVEF (r =-'0.26 and r = 0.14, respectively). Discussion: The results of this study suggest that resting plasma BNP level may be a useful clinical measure for evaluating both global functional capacity and myocardial specific work capacity in individuals with heart failure.

Original languageEnglish (US)
Pages (from-to)310-313
Number of pages4
JournalJournal of cardiopulmonary rehabilitation and prevention
Volume29
Issue number5
DOIs
StatePublished - Sep 1 2009

Fingerprint

Natriuretic Peptides
Brain Natriuretic Peptide
Heart Failure
Pressure
Exercise Test
Stroke Volume
Carbon Dioxide
Ventilation
Heart Rate
Oxygen
Blood Pressure

Keywords

  • BNP
  • Functional capacity
  • Myocardial work

ASJC Scopus subject areas

  • Rehabilitation
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Relationship of resting b-type natriuretic peptide level to cardiac work and total physical work capacity in heart failure patients. / Norman, Joseph F; Pozehl, Bunny; Duncan, Kathleen A.; Hertzog, Melody A.; Elokda, Ahmed S.; Krueger, Steven K.

In: Journal of cardiopulmonary rehabilitation and prevention, Vol. 29, No. 5, 01.09.2009, p. 310-313.

Research output: Contribution to journalArticle

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AU - Pozehl, Bunny

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AU - Hertzog, Melody A.

AU - Elokda, Ahmed S.

AU - Krueger, Steven K.

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