Relationship of Mitochondrial Enzymes to Fatigue Intensity in Men With Prostate Cancer Receiving External Beam Radiation Therapy

Kristin Filler, Debra Lyon, Nancy McCain, James Bennett, Juan Luis Fernández-Martínez, Enrique Juan deAndrés-Galiana, R. K. Elswick, Nada Lukkahatai, Leorey Saligan

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose: Mitochondrial dysfunction is a plausible biological mechanism for cancer-related fatigue. Specific aims of this study were to (1) describe the levels of mitochondrial oxidative phosphorylation complex (MOPC) enzymes, fatigue, and health-related quality of life (HRQOL) before and at completion of external beam radiation therapy (EBRT) in men with nonmetastatic prostate cancer (PC); (2) examine relationships over time among levels of MOPC enzymes, fatigue, and HRQOL; and (3) compare levels of MOPC enzymes in men with clinically significant and nonsignificant fatigue intensification during EBRT. Methods: Fatigue was measured by the revised Piper Fatigue Scale and the Functional Assessment of Cancer Therapy–Fatigue subscale (FACT-F). MOPC enzymes (Complexes I–V) and mitochondrial antioxidant superoxide dismutase 2 were measured in peripheral blood using enzyme-linked immunosorbent assay at baseline and completion of EBRT. Participants were categorized into high or low fatigue (HF vs. LF) intensification groups based on amount of change in FACT-F scores during EBRT. Results: Fatigue reported by the 22 participants with PC significantly worsened and HRQOL significantly declined from baseline to EBRT completion. The HF group comprised 12 men with clinically significant change in fatigue (HF) during EBRT. Although no significant changes were observed in MOPC enzymes from baseline to EBRT completion, there were important differences in the patterns in the levels of MOPC enzymes between HF and LF groups. Conclusion: Distinct patterns of changes in the absorbance of MOPC enzymes delineated fatigue intensification among participants. Further investigation using a larger sample is warranted.

Original languageEnglish (US)
Pages (from-to)274-280
Number of pages7
JournalBiological Research for Nursing
Volume18
Issue number3
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Fatigue
Prostatic Neoplasms
Radiotherapy
Oxidative Phosphorylation
Enzymes
Quality of Life
Piper
Neoplasms
Antioxidants
Enzyme-Linked Immunosorbent Assay

Keywords

  • fatigue
  • mitochondria
  • radiation therapy

ASJC Scopus subject areas

  • Research and Theory

Cite this

Relationship of Mitochondrial Enzymes to Fatigue Intensity in Men With Prostate Cancer Receiving External Beam Radiation Therapy. / Filler, Kristin; Lyon, Debra; McCain, Nancy; Bennett, James; Fernández-Martínez, Juan Luis; deAndrés-Galiana, Enrique Juan; Elswick, R. K.; Lukkahatai, Nada; Saligan, Leorey.

In: Biological Research for Nursing, Vol. 18, No. 3, 01.01.2015, p. 274-280.

Research output: Contribution to journalArticle

Filler, K, Lyon, D, McCain, N, Bennett, J, Fernández-Martínez, JL, deAndrés-Galiana, EJ, Elswick, RK, Lukkahatai, N & Saligan, L 2015, 'Relationship of Mitochondrial Enzymes to Fatigue Intensity in Men With Prostate Cancer Receiving External Beam Radiation Therapy', Biological Research for Nursing, vol. 18, no. 3, pp. 274-280. https://doi.org/10.1177/1099800415617848
Filler, Kristin ; Lyon, Debra ; McCain, Nancy ; Bennett, James ; Fernández-Martínez, Juan Luis ; deAndrés-Galiana, Enrique Juan ; Elswick, R. K. ; Lukkahatai, Nada ; Saligan, Leorey. / Relationship of Mitochondrial Enzymes to Fatigue Intensity in Men With Prostate Cancer Receiving External Beam Radiation Therapy. In: Biological Research for Nursing. 2015 ; Vol. 18, No. 3. pp. 274-280.
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AU - deAndrés-Galiana, Enrique Juan

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