Relationship of jejunostomy and urine polyamine content to refeeding and intestinal structure and function

Jon S Thompson, K. Laughlin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The polyamine content of the intestinal mucosa is increased with mucosal proliferation. Our purpose was to determine if urine and jejunostomy polyamine content increases after refeeding and correlates with intestinal length and carbohydrate absorption after intestinal resection. Five patients with intestinal remnant lengths ranging from 1.5 to 8 feet after intestinal resection and jejunostomy formation were studied after refeeding of an elemental diet. Mean putrescine and spermidine levels in the jejunostomy effluent but not in the urine increased significantly after refeeding (p < 0.05). These changes correlated with intestinal remnant length and carbohydrate absorption. Carbohydrate absorption correlated with polyamine levels in a single patient studied longitudinally. The polyamine content of intestinal fluid may serve as a marker of the status of the intestinal mucosa and may prove useful in the dietary management of individuals with the short bowel syndrome.

Original languageEnglish (US)
Pages (from-to)13-17
Number of pages5
JournalJournal of Parenteral and Enteral Nutrition
Volume13
Issue number1
DOIs
StatePublished - Jan 1 1989

Fingerprint

Jejunostomy
refeeding
Polyamines
polyamines
urine
Urine
Carbohydrates
resection
Intestinal Mucosa
intestinal mucosa
carbohydrates
Short Bowel Syndrome
Formulated Food
Gastrointestinal Contents
Putrescine
Spermidine
Intestinal Absorption
spermidine
putrescine
effluents

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Relationship of jejunostomy and urine polyamine content to refeeding and intestinal structure and function. / Thompson, Jon S; Laughlin, K.

In: Journal of Parenteral and Enteral Nutrition, Vol. 13, No. 1, 01.01.1989, p. 13-17.

Research output: Contribution to journalArticle

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