Relationship of ethanol to choline metabolism in the liver

a review

A. J. Barak, D. J. Tuma, Michael Floyd Sorrell

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Despite the fact that ethanol ingestion and choline deficiency appear to have related effects on the liver, no one has demonstrated a true relationship of ethanol metabolism to choline metabolism in this organ. A technique was developed for the quantitative measurement of choline uptake by the isolated perfused liver that served as a convenient model for studies involving hepatic ethanol choline relationships. These studies showed that a specific choline oxidase antagonist, 2 amino 2 methyl 1 propanol, and two nonspecific choline oxidase inhibitors depressed hepatic choline uptake indicating that this uptake is primarily a function of the choline oxidative pathway. Circulation of ethanol in liver perfusates or chronically feeding ethanol to rats was found to enhance choline uptake. Inhibition of this ethanol induced increase by pyrazole suggests that ethanol must be metabolized to produce its effect. Investigation of the effects of two metabolic products of ethanol, acetate and NADH, demonstrated that increased NADH generation due to hepatic ethanol metabolism may be responsible for the observed increase in choline utilization. The ability of the choline oxidase inhibitor to block the effect of ethanol suggests that the increased choline requirement due to alcohol may be the result of ethanol metabolism stimulating the oxidative degradation of choline in the liver.

Original languageEnglish (US)
Pages (from-to)1234-1241
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume26
Issue number11
StatePublished - Dec 1 1973

Fingerprint

choline
Choline
Ethanol
ethanol
liver
metabolism
choline oxidase
Liver
uptake mechanisms
NAD
Choline Deficiency
pyrazoles
1-propanol
antagonists
Acetates
alcohols
Eating
acetates
Alcohols
ingestion

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Relationship of ethanol to choline metabolism in the liver : a review. / Barak, A. J.; Tuma, D. J.; Sorrell, Michael Floyd.

In: American Journal of Clinical Nutrition, Vol. 26, No. 11, 01.12.1973, p. 1234-1241.

Research output: Contribution to journalReview article

@article{cc8db203af814756a44ed147cae03bf9,
title = "Relationship of ethanol to choline metabolism in the liver: a review",
abstract = "Despite the fact that ethanol ingestion and choline deficiency appear to have related effects on the liver, no one has demonstrated a true relationship of ethanol metabolism to choline metabolism in this organ. A technique was developed for the quantitative measurement of choline uptake by the isolated perfused liver that served as a convenient model for studies involving hepatic ethanol choline relationships. These studies showed that a specific choline oxidase antagonist, 2 amino 2 methyl 1 propanol, and two nonspecific choline oxidase inhibitors depressed hepatic choline uptake indicating that this uptake is primarily a function of the choline oxidative pathway. Circulation of ethanol in liver perfusates or chronically feeding ethanol to rats was found to enhance choline uptake. Inhibition of this ethanol induced increase by pyrazole suggests that ethanol must be metabolized to produce its effect. Investigation of the effects of two metabolic products of ethanol, acetate and NADH, demonstrated that increased NADH generation due to hepatic ethanol metabolism may be responsible for the observed increase in choline utilization. The ability of the choline oxidase inhibitor to block the effect of ethanol suggests that the increased choline requirement due to alcohol may be the result of ethanol metabolism stimulating the oxidative degradation of choline in the liver.",
author = "Barak, {A. J.} and Tuma, {D. J.} and Sorrell, {Michael Floyd}",
year = "1973",
month = "12",
day = "1",
language = "English (US)",
volume = "26",
pages = "1234--1241",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "11",

}

TY - JOUR

T1 - Relationship of ethanol to choline metabolism in the liver

T2 - a review

AU - Barak, A. J.

AU - Tuma, D. J.

AU - Sorrell, Michael Floyd

PY - 1973/12/1

Y1 - 1973/12/1

N2 - Despite the fact that ethanol ingestion and choline deficiency appear to have related effects on the liver, no one has demonstrated a true relationship of ethanol metabolism to choline metabolism in this organ. A technique was developed for the quantitative measurement of choline uptake by the isolated perfused liver that served as a convenient model for studies involving hepatic ethanol choline relationships. These studies showed that a specific choline oxidase antagonist, 2 amino 2 methyl 1 propanol, and two nonspecific choline oxidase inhibitors depressed hepatic choline uptake indicating that this uptake is primarily a function of the choline oxidative pathway. Circulation of ethanol in liver perfusates or chronically feeding ethanol to rats was found to enhance choline uptake. Inhibition of this ethanol induced increase by pyrazole suggests that ethanol must be metabolized to produce its effect. Investigation of the effects of two metabolic products of ethanol, acetate and NADH, demonstrated that increased NADH generation due to hepatic ethanol metabolism may be responsible for the observed increase in choline utilization. The ability of the choline oxidase inhibitor to block the effect of ethanol suggests that the increased choline requirement due to alcohol may be the result of ethanol metabolism stimulating the oxidative degradation of choline in the liver.

AB - Despite the fact that ethanol ingestion and choline deficiency appear to have related effects on the liver, no one has demonstrated a true relationship of ethanol metabolism to choline metabolism in this organ. A technique was developed for the quantitative measurement of choline uptake by the isolated perfused liver that served as a convenient model for studies involving hepatic ethanol choline relationships. These studies showed that a specific choline oxidase antagonist, 2 amino 2 methyl 1 propanol, and two nonspecific choline oxidase inhibitors depressed hepatic choline uptake indicating that this uptake is primarily a function of the choline oxidative pathway. Circulation of ethanol in liver perfusates or chronically feeding ethanol to rats was found to enhance choline uptake. Inhibition of this ethanol induced increase by pyrazole suggests that ethanol must be metabolized to produce its effect. Investigation of the effects of two metabolic products of ethanol, acetate and NADH, demonstrated that increased NADH generation due to hepatic ethanol metabolism may be responsible for the observed increase in choline utilization. The ability of the choline oxidase inhibitor to block the effect of ethanol suggests that the increased choline requirement due to alcohol may be the result of ethanol metabolism stimulating the oxidative degradation of choline in the liver.

UR - http://www.scopus.com/inward/record.url?scp=0015845978&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015845978&partnerID=8YFLogxK

M3 - Review article

VL - 26

SP - 1234

EP - 1241

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 11

ER -