Relationship between rosai-dorfman disease and IgG4-related disease: Study of 32 cases

Liping Liu, Anamarija M. Perry, Wenfeng Cao, Lynette M Smith, Eric D. Hsi, Xiuli Liu, Jun Q. Mo, Snjezana Dotlic, Marina Mosunjac, Geoffrey A Talmon, Dennis D. Weisenburger, Kai Fu

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Abstract

Objectives: To assess the association between Rosai- Dorfman disease (RDD) and IgG4-related disease (IgG4-RD). Methods: We studied the number of IgG4-positive plasma cells and the IgG4/IgG ratio in 32 biopsy specimens (13 nodal, 19 extranodal) from 29 patients with RDD and compared the findings with those in IgG4-RD of the pancreas and reactive lymph nodes. We also assessed the number of FOXP3-positive regulatory T cells (Tregs) since they were reported to be increased in IgG4-RD. Results: We found that RDD cases had much lower numbers of IgG4-positive plasma cells and lower IgG4/IgG ratios compared with IgG4-RD but were similar to reactive lymph nodes. Furthermore, RDD had lower numbers of FOXP3- positive Tregs than did IgG4-RD. There were no significant differences in the number of IgG4-positive plasma cells and the IgG4/IgG ratio between the nodal and extranodal RDD cases. Conclusions: Our study suggests that RDD does not belong in the spectrum of IgG4-RD.

Original languageEnglish (US)
Pages (from-to)395-402
Number of pages8
JournalAmerican journal of clinical pathology
Volume140
Issue number3
DOIs
StatePublished - Sep 1 2013

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Sinus Histiocytosis
Immunoglobulin G
Plasma Cells
Lymph Nodes

Keywords

  • IgG4-related disease
  • IgG4/IgG ratio
  • Regulatory T cells
  • Rosai-Dorfman disease
  • Sinus histiocytosis with massive lymphadenopathy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Relationship between rosai-dorfman disease and IgG4-related disease : Study of 32 cases. / Liu, Liping; Perry, Anamarija M.; Cao, Wenfeng; Smith, Lynette M; Hsi, Eric D.; Liu, Xiuli; Mo, Jun Q.; Dotlic, Snjezana; Mosunjac, Marina; Talmon, Geoffrey A; Weisenburger, Dennis D.; Fu, Kai.

In: American journal of clinical pathology, Vol. 140, No. 3, 01.09.2013, p. 395-402.

Research output: Contribution to journalArticle

Liu, L, Perry, AM, Cao, W, Smith, LM, Hsi, ED, Liu, X, Mo, JQ, Dotlic, S, Mosunjac, M, Talmon, GA, Weisenburger, DD & Fu, K 2013, 'Relationship between rosai-dorfman disease and IgG4-related disease: Study of 32 cases', American journal of clinical pathology, vol. 140, no. 3, pp. 395-402. https://doi.org/10.1309/AJCPFH0SJ6YILXJU
Liu, Liping ; Perry, Anamarija M. ; Cao, Wenfeng ; Smith, Lynette M ; Hsi, Eric D. ; Liu, Xiuli ; Mo, Jun Q. ; Dotlic, Snjezana ; Mosunjac, Marina ; Talmon, Geoffrey A ; Weisenburger, Dennis D. ; Fu, Kai. / Relationship between rosai-dorfman disease and IgG4-related disease : Study of 32 cases. In: American journal of clinical pathology. 2013 ; Vol. 140, No. 3. pp. 395-402.
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