Relationship between drug release and some physical parameters of drug sorption onto PLA fibers

Weijie Xu, Yiqi Yang

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Drug release and its relationship with kinetic and thermodynamic parameters of drug sorption onto poly(lactic acid) (PLA) fibers have been studied using Diclofenac, 5-Fluorouracil (5-FU) and Metformin as model drugs. The sorption method is more flexible and avoids the damaged drugs, remaining toxic organic solvents and safety problems which occurred with the dissolution method. The quantitative relationship with high correlation between drug-release and drug-loading concentration, affinity and activation energy for diffusion has been established to predict the initial burst and subsequent release of the drugs. Drugs with higher activation energy for diffusion, lower diffusion coefficients and higher affinity on PLA fiber, such as Diclofenac, can achieve high loading capacity and constant drug release. It has also been found that elevated temperatures can achieve high loading capacity and constant release. In addition, the study showed that Diclofenac release profiles were similar for sorption and dissolution loading methods.

Original languageEnglish (US)
Pages (from-to)445-462
Number of pages18
JournalJournal of Biomaterials Science, Polymer Edition
Volume21
Issue number4
DOIs
StatePublished - Mar 1 2010

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Keywords

  • Drug delivery
  • Drug-release prediction
  • Kinetics
  • Pla fibers
  • Sorption
  • Thermodynamics

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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