Relationship between air pollution and positivity of RA-related autoantibodies in individuals without established RA

A report on SERA

Ryan W. Gan, Kevin D. Deane, Gary O. Zerbe, M. Kristen Demoruelle, Michael H. Weisman, Jane H. Buckner, Peter K. Gregersen, Ted R Mikuls, James Robert O'Dell, Richard M. Keating, V. Michael Holers, Jill M. Norris

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Introduction: Studies suggest that respiratory exposures including smoking, proximity to traffic and air pollution might be associated with development of rheumatoid arthritis (RA). RA-related autoantibodies are predictive of the development of RA. Objective: We evaluated the relationship between RA-related autoantibodies and exposure to particulate matter (PM), a measure of air pollution of interest to health, in individuals without RA. Methods: The Studies of the Etiology of Rheumatoid Arthritis (SERA) is a multicentre study following firstdegree relatives (FDRs) of a proband with RA. FDRs are without the 1987 ACR (American College of Rheumatology) classifiable RA at enrolment and are followed for the development of RA-related autoimmunity. RA-related autoantibody outcomes as well as tender and swollen joint outcomes were assessed. Exposure to PM was assigned using ambient air pollution monitoring data and interpolated with inverse distance weighting spatial analyses using Geographic Information Systems. PM exposures were linked to FDR's residential zip codes. Results: RA-related autoantibodies as well as tender or swollen joints are not associated with ambient PM concentrations. Discussion: While other respiratory exposures may be associated with increased risk of RA, our data suggest that ambient PM is not associated with autoantibodies and joint signs among individuals without RA, but at increased risk of developing RA.

Original languageEnglish (US)
Pages (from-to)2002-2005
Number of pages4
JournalAnnals of the Rheumatic Diseases
Volume72
Issue number12
DOIs
StatePublished - Dec 1 2013

Fingerprint

Particulate Matter
Air Pollution
Air pollution
Autoantibodies
Rheumatoid Arthritis
Geographic information systems
Health
Monitoring
Joints
Geographic Information Systems
Spatial Analysis
Autoimmunity
Multicenter Studies

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Relationship between air pollution and positivity of RA-related autoantibodies in individuals without established RA : A report on SERA. / Gan, Ryan W.; Deane, Kevin D.; Zerbe, Gary O.; Demoruelle, M. Kristen; Weisman, Michael H.; Buckner, Jane H.; Gregersen, Peter K.; Mikuls, Ted R; O'Dell, James Robert; Keating, Richard M.; Holers, V. Michael; Norris, Jill M.

In: Annals of the Rheumatic Diseases, Vol. 72, No. 12, 01.12.2013, p. 2002-2005.

Research output: Contribution to journalArticle

Gan, RW, Deane, KD, Zerbe, GO, Demoruelle, MK, Weisman, MH, Buckner, JH, Gregersen, PK, Mikuls, TR, O'Dell, JR, Keating, RM, Holers, VM & Norris, JM 2013, 'Relationship between air pollution and positivity of RA-related autoantibodies in individuals without established RA: A report on SERA', Annals of the Rheumatic Diseases, vol. 72, no. 12, pp. 2002-2005. https://doi.org/10.1136/annrheumdis-2012-202949
Gan, Ryan W. ; Deane, Kevin D. ; Zerbe, Gary O. ; Demoruelle, M. Kristen ; Weisman, Michael H. ; Buckner, Jane H. ; Gregersen, Peter K. ; Mikuls, Ted R ; O'Dell, James Robert ; Keating, Richard M. ; Holers, V. Michael ; Norris, Jill M. / Relationship between air pollution and positivity of RA-related autoantibodies in individuals without established RA : A report on SERA. In: Annals of the Rheumatic Diseases. 2013 ; Vol. 72, No. 12. pp. 2002-2005.
@article{5083b95c3b8646e88d03b09bcb03de3c,
title = "Relationship between air pollution and positivity of RA-related autoantibodies in individuals without established RA: A report on SERA",
abstract = "Introduction: Studies suggest that respiratory exposures including smoking, proximity to traffic and air pollution might be associated with development of rheumatoid arthritis (RA). RA-related autoantibodies are predictive of the development of RA. Objective: We evaluated the relationship between RA-related autoantibodies and exposure to particulate matter (PM), a measure of air pollution of interest to health, in individuals without RA. Methods: The Studies of the Etiology of Rheumatoid Arthritis (SERA) is a multicentre study following firstdegree relatives (FDRs) of a proband with RA. FDRs are without the 1987 ACR (American College of Rheumatology) classifiable RA at enrolment and are followed for the development of RA-related autoimmunity. RA-related autoantibody outcomes as well as tender and swollen joint outcomes were assessed. Exposure to PM was assigned using ambient air pollution monitoring data and interpolated with inverse distance weighting spatial analyses using Geographic Information Systems. PM exposures were linked to FDR's residential zip codes. Results: RA-related autoantibodies as well as tender or swollen joints are not associated with ambient PM concentrations. Discussion: While other respiratory exposures may be associated with increased risk of RA, our data suggest that ambient PM is not associated with autoantibodies and joint signs among individuals without RA, but at increased risk of developing RA.",
author = "Gan, {Ryan W.} and Deane, {Kevin D.} and Zerbe, {Gary O.} and Demoruelle, {M. Kristen} and Weisman, {Michael H.} and Buckner, {Jane H.} and Gregersen, {Peter K.} and Mikuls, {Ted R} and O'Dell, {James Robert} and Keating, {Richard M.} and Holers, {V. Michael} and Norris, {Jill M.}",
year = "2013",
month = "12",
day = "1",
doi = "10.1136/annrheumdis-2012-202949",
language = "English (US)",
volume = "72",
pages = "2002--2005",
journal = "Annals of the Rheumatic Diseases",
issn = "0003-4967",
publisher = "BMJ Publishing Group",
number = "12",

}

TY - JOUR

T1 - Relationship between air pollution and positivity of RA-related autoantibodies in individuals without established RA

T2 - A report on SERA

AU - Gan, Ryan W.

AU - Deane, Kevin D.

AU - Zerbe, Gary O.

AU - Demoruelle, M. Kristen

AU - Weisman, Michael H.

AU - Buckner, Jane H.

AU - Gregersen, Peter K.

AU - Mikuls, Ted R

AU - O'Dell, James Robert

AU - Keating, Richard M.

AU - Holers, V. Michael

AU - Norris, Jill M.

PY - 2013/12/1

Y1 - 2013/12/1

N2 - Introduction: Studies suggest that respiratory exposures including smoking, proximity to traffic and air pollution might be associated with development of rheumatoid arthritis (RA). RA-related autoantibodies are predictive of the development of RA. Objective: We evaluated the relationship between RA-related autoantibodies and exposure to particulate matter (PM), a measure of air pollution of interest to health, in individuals without RA. Methods: The Studies of the Etiology of Rheumatoid Arthritis (SERA) is a multicentre study following firstdegree relatives (FDRs) of a proband with RA. FDRs are without the 1987 ACR (American College of Rheumatology) classifiable RA at enrolment and are followed for the development of RA-related autoimmunity. RA-related autoantibody outcomes as well as tender and swollen joint outcomes were assessed. Exposure to PM was assigned using ambient air pollution monitoring data and interpolated with inverse distance weighting spatial analyses using Geographic Information Systems. PM exposures were linked to FDR's residential zip codes. Results: RA-related autoantibodies as well as tender or swollen joints are not associated with ambient PM concentrations. Discussion: While other respiratory exposures may be associated with increased risk of RA, our data suggest that ambient PM is not associated with autoantibodies and joint signs among individuals without RA, but at increased risk of developing RA.

AB - Introduction: Studies suggest that respiratory exposures including smoking, proximity to traffic and air pollution might be associated with development of rheumatoid arthritis (RA). RA-related autoantibodies are predictive of the development of RA. Objective: We evaluated the relationship between RA-related autoantibodies and exposure to particulate matter (PM), a measure of air pollution of interest to health, in individuals without RA. Methods: The Studies of the Etiology of Rheumatoid Arthritis (SERA) is a multicentre study following firstdegree relatives (FDRs) of a proband with RA. FDRs are without the 1987 ACR (American College of Rheumatology) classifiable RA at enrolment and are followed for the development of RA-related autoimmunity. RA-related autoantibody outcomes as well as tender and swollen joint outcomes were assessed. Exposure to PM was assigned using ambient air pollution monitoring data and interpolated with inverse distance weighting spatial analyses using Geographic Information Systems. PM exposures were linked to FDR's residential zip codes. Results: RA-related autoantibodies as well as tender or swollen joints are not associated with ambient PM concentrations. Discussion: While other respiratory exposures may be associated with increased risk of RA, our data suggest that ambient PM is not associated with autoantibodies and joint signs among individuals without RA, but at increased risk of developing RA.

UR - http://www.scopus.com/inward/record.url?scp=84887443657&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887443657&partnerID=8YFLogxK

U2 - 10.1136/annrheumdis-2012-202949

DO - 10.1136/annrheumdis-2012-202949

M3 - Article

VL - 72

SP - 2002

EP - 2005

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

IS - 12

ER -