Rehospitalization in Infants Born < 29 Weeks' Gestation during the First 2 Years of Life

Risk Assessment

Jane B. Taylor, Mitzi A. Go, Michael F. Nyp, Jennifer Legino, Michael Norberg, Hongying Dai, William E. Truog

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective This study aims to determine risk factors for rehospitalization in extremely premature infants. Study Design A retrospective cohort study of 157 infants born < 29 weeks' gestational age assessing risk factors for rehospitalization through 2 years of life. Results Multivariable logistic regression showed that an increasing number of respiratory infections (odds ratio [OR]: 1.8 [1.1-3.1] per infection p = 0.03) and inhaled steroid use at 1 year (OR: 4.0 [1.3-12.1] p = 0.01) were predictive of hospital readmission. Diuretic (OR: 27 [1.01-1,000] p = 0.04) and oxygen (OR: 32 [3.1-333] p = 0.004) use at 1 year were predictive of pediatric intensive care unit admission. The number of respiratory infections (OR: 2.8 [1.7-4.5] p < 0.0001) with reflux/aspiration necessitating G-tube/Nissen fundoplication surgical intervention with or without G-tubes alone (OR: 21.3 [2.9-166.7] p = 0.02 and OR: 22.7 [CI, 2.4-200] p = 0.04) was predictive of increased number of rehospitalizations. Conclusions Key modifiable risk factors identified were reflux/aspiration and ongoing respiratory infections. Critical time periods for diuretic, oxygen, and inhaled steroid use in this population occurred at the age of 1 year.

Original languageEnglish (US)
Pages (from-to)24-33
Number of pages10
JournalAmerican Journal of Perinatology
Volume33
Issue number1
DOIs
StatePublished - Jun 17 2015
Externally publishedYes

Fingerprint

Odds Ratio
Pregnancy
Respiratory Tract Infections
Diuretics
Steroids
Extremely Premature Infants
Oxygen
Patient Readmission
Fundoplication
Pediatric Intensive Care Units
Gestational Age
Cohort Studies
Retrospective Studies
Logistic Models
Infection
Population

Keywords

  • bronchopulmonary dysplasia
  • dysphagia
  • prematurity
  • pulmonary hypertension
  • rehospitalization
  • respiratory infection

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Rehospitalization in Infants Born < 29 Weeks' Gestation during the First 2 Years of Life : Risk Assessment. / Taylor, Jane B.; Go, Mitzi A.; Nyp, Michael F.; Legino, Jennifer; Norberg, Michael; Dai, Hongying; Truog, William E.

In: American Journal of Perinatology, Vol. 33, No. 1, 17.06.2015, p. 24-33.

Research output: Contribution to journalArticle

Taylor, Jane B. ; Go, Mitzi A. ; Nyp, Michael F. ; Legino, Jennifer ; Norberg, Michael ; Dai, Hongying ; Truog, William E. / Rehospitalization in Infants Born < 29 Weeks' Gestation during the First 2 Years of Life : Risk Assessment. In: American Journal of Perinatology. 2015 ; Vol. 33, No. 1. pp. 24-33.
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N2 - Objective This study aims to determine risk factors for rehospitalization in extremely premature infants. Study Design A retrospective cohort study of 157 infants born < 29 weeks' gestational age assessing risk factors for rehospitalization through 2 years of life. Results Multivariable logistic regression showed that an increasing number of respiratory infections (odds ratio [OR]: 1.8 [1.1-3.1] per infection p = 0.03) and inhaled steroid use at 1 year (OR: 4.0 [1.3-12.1] p = 0.01) were predictive of hospital readmission. Diuretic (OR: 27 [1.01-1,000] p = 0.04) and oxygen (OR: 32 [3.1-333] p = 0.004) use at 1 year were predictive of pediatric intensive care unit admission. The number of respiratory infections (OR: 2.8 [1.7-4.5] p < 0.0001) with reflux/aspiration necessitating G-tube/Nissen fundoplication surgical intervention with or without G-tubes alone (OR: 21.3 [2.9-166.7] p = 0.02 and OR: 22.7 [CI, 2.4-200] p = 0.04) was predictive of increased number of rehospitalizations. Conclusions Key modifiable risk factors identified were reflux/aspiration and ongoing respiratory infections. Critical time periods for diuretic, oxygen, and inhaled steroid use in this population occurred at the age of 1 year.

AB - Objective This study aims to determine risk factors for rehospitalization in extremely premature infants. Study Design A retrospective cohort study of 157 infants born < 29 weeks' gestational age assessing risk factors for rehospitalization through 2 years of life. Results Multivariable logistic regression showed that an increasing number of respiratory infections (odds ratio [OR]: 1.8 [1.1-3.1] per infection p = 0.03) and inhaled steroid use at 1 year (OR: 4.0 [1.3-12.1] p = 0.01) were predictive of hospital readmission. Diuretic (OR: 27 [1.01-1,000] p = 0.04) and oxygen (OR: 32 [3.1-333] p = 0.004) use at 1 year were predictive of pediatric intensive care unit admission. The number of respiratory infections (OR: 2.8 [1.7-4.5] p < 0.0001) with reflux/aspiration necessitating G-tube/Nissen fundoplication surgical intervention with or without G-tubes alone (OR: 21.3 [2.9-166.7] p = 0.02 and OR: 22.7 [CI, 2.4-200] p = 0.04) was predictive of increased number of rehospitalizations. Conclusions Key modifiable risk factors identified were reflux/aspiration and ongoing respiratory infections. Critical time periods for diuretic, oxygen, and inhaled steroid use in this population occurred at the age of 1 year.

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