Regulatory effects of interleukin-11 during acute lung inflammatory injury

Alex B. Lentsch, Larry D Crouch, Jacqueline A. Jordan, Boris J. Czermak, Edward C. Yun, Guo Renfeng, Vidya Sarma, Kathleen M. Diehl, Peter A. Ward

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The role of interleukin-11 (IL-11) was evaluated in the IgG immune complex model of acute lung injury in rats. IL-11 mRNA and protein were both up-regulated during the course of this inflammatory response. Exogenously administered IL-11 substantially reduced, in a dose-dependent manner, the intrapulmonary accumulation of neutrophils and the lung vascular leak of albumin. These in vivo anti-inflammatory effects of IL-11 were associated with reduced NF-κB activation in lung, reduced levels of tumor necrosis factor α (TNF-α) in bronchoalveolar lavage (BAL) fluids, and diminished up- regulation of lung vascular ICAM-1. It is interesting that IL-11 did not affect BAL fluid content of the CXC chemokines, macrophage inflammatory protein-2 (MIP-2) and cytokine-inducible neutrophil chemoattractant (CINC); the presence of IL-11 did not affect these chemokines. However, BAL content of C5a was reduced by IL-11. These data indicate that IL-11 is a regulatory cytokine in the lung and that, like other members of this family, its anti- inflammatory properties appear to be linked to its suppression of NF-κB activation, diminished production of TNF-α, and reduced up-regulation of lung vascular ICAM-1.

Original languageEnglish (US)
Pages (from-to)151-157
Number of pages7
JournalJournal of Leukocyte Biology
Volume66
Issue number1
DOIs
StatePublished - Jan 1 1999

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Interleukin-11
Acute Lung Injury
Lung
Blood Vessels
Bronchoalveolar Lavage Fluid
Intercellular Adhesion Molecule-1
Neutrophils
Anti-Inflammatory Agents
Up-Regulation
Tumor Necrosis Factor-alpha
Chemokine CXCL2
Cytokines
CXC Chemokines
Chemotactic Factors
Bronchoalveolar Lavage
Antigen-Antibody Complex
Chemokines
Albumins
Immunoglobulin G
Messenger RNA

Keywords

  • C5α
  • Chemokines
  • ICAM-1
  • NF-κB
  • Neutrophils
  • Tumor necrosis factor α

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology

Cite this

Lentsch, A. B., Crouch, L. D., Jordan, J. A., Czermak, B. J., Yun, E. C., Renfeng, G., ... Ward, P. A. (1999). Regulatory effects of interleukin-11 during acute lung inflammatory injury. Journal of Leukocyte Biology, 66(1), 151-157. https://doi.org/10.1002/jlb.66.1.151

Regulatory effects of interleukin-11 during acute lung inflammatory injury. / Lentsch, Alex B.; Crouch, Larry D; Jordan, Jacqueline A.; Czermak, Boris J.; Yun, Edward C.; Renfeng, Guo; Sarma, Vidya; Diehl, Kathleen M.; Ward, Peter A.

In: Journal of Leukocyte Biology, Vol. 66, No. 1, 01.01.1999, p. 151-157.

Research output: Contribution to journalArticle

Lentsch, AB, Crouch, LD, Jordan, JA, Czermak, BJ, Yun, EC, Renfeng, G, Sarma, V, Diehl, KM & Ward, PA 1999, 'Regulatory effects of interleukin-11 during acute lung inflammatory injury', Journal of Leukocyte Biology, vol. 66, no. 1, pp. 151-157. https://doi.org/10.1002/jlb.66.1.151
Lentsch, Alex B. ; Crouch, Larry D ; Jordan, Jacqueline A. ; Czermak, Boris J. ; Yun, Edward C. ; Renfeng, Guo ; Sarma, Vidya ; Diehl, Kathleen M. ; Ward, Peter A. / Regulatory effects of interleukin-11 during acute lung inflammatory injury. In: Journal of Leukocyte Biology. 1999 ; Vol. 66, No. 1. pp. 151-157.
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