Regulatory effects of adrenal gland products in IgG immune complex acute lung injury

Larry D. Crouch, Alex B. Lentsch, Roscoe L. Warner, Kent J. Johnson, Peter A. Ward

Research output: Contribution to journalArticle

Abstract

Adrenal gland-derived corticosterone and epinephrine are thought to function as endogenous antiinflammatory mediators of inflammatory injury. To determine whether adrenalectomy impacts inflammatory processes associated with IgG immune complex-mediated acute lung injury, adrenalectomized and sham adrenal-ectomized Long Evans rats were treated with IgG or saline intratracheally. IgG immune complex lung injury resulted in a two-fold increase in pulmonary vascular permeability for serum albumin in adrenalectomized rats, compared to adrenal-intact animals. This increase in injury was associated with increases in NF-κB activity in whole lung homogenates, bronchoalveolar lavage fluid TNFα concentrations, pulmonary vascular ICAM-1 expression and whole lung myeloperoxidase activity. Adrenalectomy did not alter nitric oxide content in bronchoalveolar lavage fluid. Adrenalectomized saline-treated rats also had increased ICAM-1 expression and pulmonary vascular permeability, compared to saline-treated adrenal-intact sham animals. These data suggest that adrenal gland-derived mediators regulate either directly or indirectly several parameters of inflammatory signaling and activation in the IgG immune complex-injured lung.

Original languageEnglish (US)
Pages (from-to)A124
JournalFASEB Journal
Volume11
Issue number3
StatePublished - Dec 1 1997

Fingerprint

antigen-antibody complex
Acute Lung Injury
adrenal glands
Adrenal Glands
Antigen-Antibody Complex
Immunoglobulin G
lungs
Rats
Lung
Intercellular Adhesion Molecule-1
Animals
Adrenalectomy
Bronchoalveolar Lavage Fluid
blood vessels
Capillary Permeability
Fluids
Corticosterone
Serum Albumin
Peroxidase
Epinephrine

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Crouch, L. D., Lentsch, A. B., Warner, R. L., Johnson, K. J., & Ward, P. A. (1997). Regulatory effects of adrenal gland products in IgG immune complex acute lung injury. FASEB Journal, 11(3), A124.

Regulatory effects of adrenal gland products in IgG immune complex acute lung injury. / Crouch, Larry D.; Lentsch, Alex B.; Warner, Roscoe L.; Johnson, Kent J.; Ward, Peter A.

In: FASEB Journal, Vol. 11, No. 3, 01.12.1997, p. A124.

Research output: Contribution to journalArticle

Crouch, LD, Lentsch, AB, Warner, RL, Johnson, KJ & Ward, PA 1997, 'Regulatory effects of adrenal gland products in IgG immune complex acute lung injury', FASEB Journal, vol. 11, no. 3, pp. A124.
Crouch LD, Lentsch AB, Warner RL, Johnson KJ, Ward PA. Regulatory effects of adrenal gland products in IgG immune complex acute lung injury. FASEB Journal. 1997 Dec 1;11(3):A124.
Crouch, Larry D. ; Lentsch, Alex B. ; Warner, Roscoe L. ; Johnson, Kent J. ; Ward, Peter A. / Regulatory effects of adrenal gland products in IgG immune complex acute lung injury. In: FASEB Journal. 1997 ; Vol. 11, No. 3. pp. A124.
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