Regulatory CD4+CD25+ T cells and macrophages: Communication between two regulators of effector T cells

Y. Zhen, Jialin C Zheng, Y. Zhao

Research output: Contribution to journalReview article

14 Scopus citations


Regulatory T cells (Tregs) play an essential role in the induction and maintenance of peripheral tolerance as well as prevention of autoimmunity by limiting the strength of the immune response of effector T cells. Macrophages, a heterogeneous population of phagocytes and professional antigen presenting cells (APCs), can also exert suppressive effects on effector T cells to keep the peripheral balance of immunity. The bi-directional interactions of dendritic cells (DCs) and Tregs have been cell studied. However, much less is known about the reciprocal interaction between macrophages and Tregs. In this review, we will discuss recent observations regarding the interplay of these two regulators of immunity.

Original languageEnglish (US)
Pages (from-to)564-570
Number of pages7
JournalInflammation Research
Issue number12
Publication statusPublished - Dec 1 2008



  • Effector T cells
  • Interaction
  • Macrophages
  • Regulatory T cells

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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