Regulation of p53 stability and apoptosis by a ROR agonist

Yongjun Wang, Laura A. Solt, Douglas J. Kojetin, Thomas P. Burris

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Activation of p53 function leading to cell-cycle arrest and/or apoptosis is a promising strategy for development of anti-cancer therapeutic agents. Here, we describe a novel mechanism for stabilization of p53 protein expression via activation of the orphan nuclear receptor, RORα. We demonstrate that treatment of cancer cells with a newly described synthetic ROR agonist, SR1078, leads to p53 stabilization and induction of apoptosis. These data suggest that synthetic ROR agonists may hold utility in the treatment of cancer.

Original languageEnglish (US)
Article numbere34921
JournalPloS one
Volume7
Issue number4
DOIs
StatePublished - Apr 16 2012

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agonists
apoptosis
Stabilization
Chemical activation
Cells
Orphan Nuclear Receptors
Apoptosis
neoplasms
Neoplasms
protein synthesis
Cell Cycle Checkpoints
therapeutics
receptors
Proteins
Therapeutics
SR 1078
neoplasm cells
cell cycle checkpoints

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Regulation of p53 stability and apoptosis by a ROR agonist. / Wang, Yongjun; Solt, Laura A.; Kojetin, Douglas J.; Burris, Thomas P.

In: PloS one, Vol. 7, No. 4, e34921, 16.04.2012.

Research output: Contribution to journalArticle

Wang, Yongjun ; Solt, Laura A. ; Kojetin, Douglas J. ; Burris, Thomas P. / Regulation of p53 stability and apoptosis by a ROR agonist. In: PloS one. 2012 ; Vol. 7, No. 4.
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