Regulation of major histocompatibility complex class i molecule expression on cancer cells by amyloid precursor-like protein 2

Haley L. Peters, Amit Tuli, Mahak Sharma, Naava Naslavsky, Steve Caplan, Richard G. MacDonald, Joyce C. Solheim

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The three members of the amyloid precursor protein family in mammals [amyloid precursor protein, amyloid precursor-like protein 1, and amyloid precursor-like protein 2 (APLP2)] have been implicated in a large array of intracellular processes, which include development, transcription, apoptosis, metabolism, and the cell cycle. A series of studies by our laboratories has demonstrated that APLP2 is highly expressed by many cancer cell lines (with the highest expression in pancreatic cancer cell lines) and that it facilitates major histocompatibility complex (MHC) class I molecule endocytosis. This review focuses on this recently revealed function of APLP2 relevant to tumor immunology: that it acts as a novel regulator of MHC class I molecule surface expression.

Original languageEnglish (US)
Pages (from-to)39-44
Number of pages6
JournalImmunologic Research
Volume51
Issue number1
DOIs
StatePublished - Oct 1 2011

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Keywords

  • Amyloid precursor-like protein 2
  • Antigen presentation
  • Cancer
  • Endocytosis
  • Human leukocyte antigen
  • Major histocompatibility complex class I molecule
  • Trafficking
  • Tumor antigen
  • Tumor immunology

ASJC Scopus subject areas

  • Immunology

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