Regulation of lung immunity and host defense by the intestinal microbiota

Derrick R. Samuelson, David A. Welsh, Judd E. Shellito

Research output: Contribution to journalReview article

Abstract

Every year in the United States approximately 200,000 people die from pulmonary infections, such as influenza and pneumonia, or from lung disease that is exacerbated by pulmonary infection. In addition, respiratory diseases such as, asthma, affect 300 million people worldwide. Therefore, understanding the mechanistic basis for host defense against infection and regulation of immune processes involved in asthma are crucial for the development of novel therapeutic strategies. The identification, characterization, and manipulation of immune regulatory networks in the lung represents one of the biggest challenges in treatment of lung associated disease. Recent evidence suggests that the gastrointestinal (GI) microbiota plays a key role in immune adaptation and initiation in the GI tract as well as at other distal mucosal sites, such as the lung. This review explores the current research describing the role of the GI microbiota in the regulation of pulmonary immune responses. Specific focus is given to understanding how intestinal "dysbiosis" affects lung health.

Original languageEnglish (US)
Article number1085
JournalFrontiers in Microbiology
Volume6
Issue numberOCT
DOIs
StatePublished - Jan 1 2015

Fingerprint

Immunity
Lung
Lung Diseases
Asthma
Infection
Dysbiosis
Human Influenza
Gastrointestinal Tract
Gastrointestinal Microbiome
Pneumonia
Health
Research
Therapeutics

Keywords

  • Dysbiosis
  • Gut-Lung Axis
  • Immunology
  • Intestinal microbiota
  • Pulmonary immunology
  • Pulmonary infections

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Regulation of lung immunity and host defense by the intestinal microbiota. / Samuelson, Derrick R.; Welsh, David A.; Shellito, Judd E.

In: Frontiers in Microbiology, Vol. 6, No. OCT, 1085, 01.01.2015.

Research output: Contribution to journalReview article

@article{b7cd30fc555249b5b758385f1c3405bb,
title = "Regulation of lung immunity and host defense by the intestinal microbiota",
abstract = "Every year in the United States approximately 200,000 people die from pulmonary infections, such as influenza and pneumonia, or from lung disease that is exacerbated by pulmonary infection. In addition, respiratory diseases such as, asthma, affect 300 million people worldwide. Therefore, understanding the mechanistic basis for host defense against infection and regulation of immune processes involved in asthma are crucial for the development of novel therapeutic strategies. The identification, characterization, and manipulation of immune regulatory networks in the lung represents one of the biggest challenges in treatment of lung associated disease. Recent evidence suggests that the gastrointestinal (GI) microbiota plays a key role in immune adaptation and initiation in the GI tract as well as at other distal mucosal sites, such as the lung. This review explores the current research describing the role of the GI microbiota in the regulation of pulmonary immune responses. Specific focus is given to understanding how intestinal {"}dysbiosis{"} affects lung health.",
keywords = "Dysbiosis, Gut-Lung Axis, Immunology, Intestinal microbiota, Pulmonary immunology, Pulmonary infections",
author = "Samuelson, {Derrick R.} and Welsh, {David A.} and Shellito, {Judd E.}",
year = "2015",
month = "1",
day = "1",
doi = "10.3389/fmicb.2015.01085",
language = "English (US)",
volume = "6",
journal = "Frontiers in Microbiology",
issn = "1664-302X",
publisher = "Frontiers Media S. A.",
number = "OCT",

}

TY - JOUR

T1 - Regulation of lung immunity and host defense by the intestinal microbiota

AU - Samuelson, Derrick R.

AU - Welsh, David A.

AU - Shellito, Judd E.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Every year in the United States approximately 200,000 people die from pulmonary infections, such as influenza and pneumonia, or from lung disease that is exacerbated by pulmonary infection. In addition, respiratory diseases such as, asthma, affect 300 million people worldwide. Therefore, understanding the mechanistic basis for host defense against infection and regulation of immune processes involved in asthma are crucial for the development of novel therapeutic strategies. The identification, characterization, and manipulation of immune regulatory networks in the lung represents one of the biggest challenges in treatment of lung associated disease. Recent evidence suggests that the gastrointestinal (GI) microbiota plays a key role in immune adaptation and initiation in the GI tract as well as at other distal mucosal sites, such as the lung. This review explores the current research describing the role of the GI microbiota in the regulation of pulmonary immune responses. Specific focus is given to understanding how intestinal "dysbiosis" affects lung health.

AB - Every year in the United States approximately 200,000 people die from pulmonary infections, such as influenza and pneumonia, or from lung disease that is exacerbated by pulmonary infection. In addition, respiratory diseases such as, asthma, affect 300 million people worldwide. Therefore, understanding the mechanistic basis for host defense against infection and regulation of immune processes involved in asthma are crucial for the development of novel therapeutic strategies. The identification, characterization, and manipulation of immune regulatory networks in the lung represents one of the biggest challenges in treatment of lung associated disease. Recent evidence suggests that the gastrointestinal (GI) microbiota plays a key role in immune adaptation and initiation in the GI tract as well as at other distal mucosal sites, such as the lung. This review explores the current research describing the role of the GI microbiota in the regulation of pulmonary immune responses. Specific focus is given to understanding how intestinal "dysbiosis" affects lung health.

KW - Dysbiosis

KW - Gut-Lung Axis

KW - Immunology

KW - Intestinal microbiota

KW - Pulmonary immunology

KW - Pulmonary infections

UR - http://www.scopus.com/inward/record.url?scp=84946837224&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946837224&partnerID=8YFLogxK

U2 - 10.3389/fmicb.2015.01085

DO - 10.3389/fmicb.2015.01085

M3 - Review article

C2 - 26500629

AN - SCOPUS:84946837224

VL - 6

JO - Frontiers in Microbiology

JF - Frontiers in Microbiology

SN - 1664-302X

IS - OCT

M1 - 1085

ER -