Regulation of innate immune responses by Bovine herpesvirus 1 and infected cell protein 0 (bICP0)

Clinton Jones

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

Bovine herpesvirus 1 (BoHV-1) infected cell protein 0 (bICP0) is an important transcriptional regulatory protein that stimulates productive infection. In transient transfection assays, bICP0 also inhibits interferon dependent transcription. bICP0 can induce degradation of interferon stimulatory factor 3 (IRF3), a cellular transcription factor that is crucial for activating beta interferon (IFN-β) promoter activity. Recent studies also concluded that interactions between bICP0 and IRF7 inhibit trans-activation of IFN-β promoter activity. The C3HC4 zinc RING (really important new gene) finger located near the amino terminus of bICP0 is important for all known functions of bICP0. A recombinant virus that contains a single amino acid change in a well conserved cysteine residue of the C3HC4 zinc RING finger of bICP0 grows poorly in cultured cells, and does not reactivate from latency in cattle confirming that the C3HC4 zinc RING finger is crucial for viral growth and pathogenesis. A bICP0 deletion mutant does not induce plaques in permissive cells, but induces autophagy in a cell type dependent manner. In summary, the ability of bICP0 to stimulate productive infection, and repress IFN dependent transcription plays a crucial role in the BoHV-1 infection cycle.

Original languageEnglish (US)
Pages (from-to)255-275
Number of pages21
JournalViruses
Volume1
Issue number2
DOIs
StatePublished - Sep 7 2009

Fingerprint

Innate Immunity
Interferons
Zinc
Bovine Herpesvirus 1
Genes
Bovine herpesvirus 1 bICP0 protein
Herpesviridae Infections
Interferon-beta
Autophagy
Infection
Fingers
Transfection
Cysteine
Cultured Cells
Transcription Factors
Viruses
Amino Acids
Growth

Keywords

  • Bovine herpesvirus 1 (BoHV-1)
  • IRF3
  • IRF7
  • Interferon
  • Transcriptional regulation
  • bICP0

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

Regulation of innate immune responses by Bovine herpesvirus 1 and infected cell protein 0 (bICP0). / Jones, Clinton.

In: Viruses, Vol. 1, No. 2, 07.09.2009, p. 255-275.

Research output: Contribution to journalReview article

@article{88dff87dbdae4aab927da46bcbf0c186,
title = "Regulation of innate immune responses by Bovine herpesvirus 1 and infected cell protein 0 (bICP0)",
abstract = "Bovine herpesvirus 1 (BoHV-1) infected cell protein 0 (bICP0) is an important transcriptional regulatory protein that stimulates productive infection. In transient transfection assays, bICP0 also inhibits interferon dependent transcription. bICP0 can induce degradation of interferon stimulatory factor 3 (IRF3), a cellular transcription factor that is crucial for activating beta interferon (IFN-β) promoter activity. Recent studies also concluded that interactions between bICP0 and IRF7 inhibit trans-activation of IFN-β promoter activity. The C3HC4 zinc RING (really important new gene) finger located near the amino terminus of bICP0 is important for all known functions of bICP0. A recombinant virus that contains a single amino acid change in a well conserved cysteine residue of the C3HC4 zinc RING finger of bICP0 grows poorly in cultured cells, and does not reactivate from latency in cattle confirming that the C3HC4 zinc RING finger is crucial for viral growth and pathogenesis. A bICP0 deletion mutant does not induce plaques in permissive cells, but induces autophagy in a cell type dependent manner. In summary, the ability of bICP0 to stimulate productive infection, and repress IFN dependent transcription plays a crucial role in the BoHV-1 infection cycle.",
keywords = "Bovine herpesvirus 1 (BoHV-1), IRF3, IRF7, Interferon, Transcriptional regulation, bICP0",
author = "Clinton Jones",
year = "2009",
month = "9",
day = "7",
doi = "10.3390/v1020255",
language = "English (US)",
volume = "1",
pages = "255--275",
journal = "Viruses",
issn = "1999-4915",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "2",

}

TY - JOUR

T1 - Regulation of innate immune responses by Bovine herpesvirus 1 and infected cell protein 0 (bICP0)

AU - Jones, Clinton

PY - 2009/9/7

Y1 - 2009/9/7

N2 - Bovine herpesvirus 1 (BoHV-1) infected cell protein 0 (bICP0) is an important transcriptional regulatory protein that stimulates productive infection. In transient transfection assays, bICP0 also inhibits interferon dependent transcription. bICP0 can induce degradation of interferon stimulatory factor 3 (IRF3), a cellular transcription factor that is crucial for activating beta interferon (IFN-β) promoter activity. Recent studies also concluded that interactions between bICP0 and IRF7 inhibit trans-activation of IFN-β promoter activity. The C3HC4 zinc RING (really important new gene) finger located near the amino terminus of bICP0 is important for all known functions of bICP0. A recombinant virus that contains a single amino acid change in a well conserved cysteine residue of the C3HC4 zinc RING finger of bICP0 grows poorly in cultured cells, and does not reactivate from latency in cattle confirming that the C3HC4 zinc RING finger is crucial for viral growth and pathogenesis. A bICP0 deletion mutant does not induce plaques in permissive cells, but induces autophagy in a cell type dependent manner. In summary, the ability of bICP0 to stimulate productive infection, and repress IFN dependent transcription plays a crucial role in the BoHV-1 infection cycle.

AB - Bovine herpesvirus 1 (BoHV-1) infected cell protein 0 (bICP0) is an important transcriptional regulatory protein that stimulates productive infection. In transient transfection assays, bICP0 also inhibits interferon dependent transcription. bICP0 can induce degradation of interferon stimulatory factor 3 (IRF3), a cellular transcription factor that is crucial for activating beta interferon (IFN-β) promoter activity. Recent studies also concluded that interactions between bICP0 and IRF7 inhibit trans-activation of IFN-β promoter activity. The C3HC4 zinc RING (really important new gene) finger located near the amino terminus of bICP0 is important for all known functions of bICP0. A recombinant virus that contains a single amino acid change in a well conserved cysteine residue of the C3HC4 zinc RING finger of bICP0 grows poorly in cultured cells, and does not reactivate from latency in cattle confirming that the C3HC4 zinc RING finger is crucial for viral growth and pathogenesis. A bICP0 deletion mutant does not induce plaques in permissive cells, but induces autophagy in a cell type dependent manner. In summary, the ability of bICP0 to stimulate productive infection, and repress IFN dependent transcription plays a crucial role in the BoHV-1 infection cycle.

KW - Bovine herpesvirus 1 (BoHV-1)

KW - IRF3

KW - IRF7

KW - Interferon

KW - Transcriptional regulation

KW - bICP0

UR - http://www.scopus.com/inward/record.url?scp=77953301617&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953301617&partnerID=8YFLogxK

U2 - 10.3390/v1020255

DO - 10.3390/v1020255

M3 - Review article

C2 - 21994549

AN - SCOPUS:77953301617

VL - 1

SP - 255

EP - 275

JO - Viruses

JF - Viruses

SN - 1999-4915

IS - 2

ER -