Regulation of eye development by Protein serine/threonine phosphatases-1 and -2A

L. Wang, Y. Yang, X. D. Gong, Z. X. Huang, Q. Nie, Z. F. Wang, W. K. Ji, X. H. Hu, W. F. Hu, L. L. Gong, L. Zhang, S. Huang, R. L. Qi, T. H. Yang, Z. G. Chen, W. B. Liu, Y. Z. Liu, D. W C Li

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The protein serine/threonine phosphatases-1 and -2A are major cellular phosphatases, playing a fundamental role in organisms from prokaryotes to eukaryotes. They contribute to 90% dephosphorylation in eukaryote proteins. In the eye, both phosphatases are highly expressed and display important functions in regulating normal eye development. Moreover, they are implicated in pathogenesis through modulation of stress-induced apoptosis. Here we review the recent progresses on these aspects.

Original languageEnglish (US)
Pages (from-to)944-951
Number of pages8
JournalCurrent Molecular Medicine
Volume15
Issue number10
StatePublished - Dec 1 2015

Fingerprint

Eye Proteins
Phosphoprotein Phosphatases
Eukaryota
Phosphoric Monoester Hydrolases
Modulation
Apoptosis
Proteins

Keywords

  • Developmental apoptosis
  • Eye development
  • Lens differentiation
  • Serine/threonine phosphatases-1 and -2A

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Molecular Medicine

Cite this

Wang, L., Yang, Y., Gong, X. D., Huang, Z. X., Nie, Q., Wang, Z. F., ... Li, D. W. C. (2015). Regulation of eye development by Protein serine/threonine phosphatases-1 and -2A. Current Molecular Medicine, 15(10), 944-951.

Regulation of eye development by Protein serine/threonine phosphatases-1 and -2A. / Wang, L.; Yang, Y.; Gong, X. D.; Huang, Z. X.; Nie, Q.; Wang, Z. F.; Ji, W. K.; Hu, X. H.; Hu, W. F.; Gong, L. L.; Zhang, L.; Huang, S.; Qi, R. L.; Yang, T. H.; Chen, Z. G.; Liu, W. B.; Liu, Y. Z.; Li, D. W C.

In: Current Molecular Medicine, Vol. 15, No. 10, 01.12.2015, p. 944-951.

Research output: Contribution to journalArticle

Wang, L, Yang, Y, Gong, XD, Huang, ZX, Nie, Q, Wang, ZF, Ji, WK, Hu, XH, Hu, WF, Gong, LL, Zhang, L, Huang, S, Qi, RL, Yang, TH, Chen, ZG, Liu, WB, Liu, YZ & Li, DWC 2015, 'Regulation of eye development by Protein serine/threonine phosphatases-1 and -2A', Current Molecular Medicine, vol. 15, no. 10, pp. 944-951.
Wang L, Yang Y, Gong XD, Huang ZX, Nie Q, Wang ZF et al. Regulation of eye development by Protein serine/threonine phosphatases-1 and -2A. Current Molecular Medicine. 2015 Dec 1;15(10):944-951.
Wang, L. ; Yang, Y. ; Gong, X. D. ; Huang, Z. X. ; Nie, Q. ; Wang, Z. F. ; Ji, W. K. ; Hu, X. H. ; Hu, W. F. ; Gong, L. L. ; Zhang, L. ; Huang, S. ; Qi, R. L. ; Yang, T. H. ; Chen, Z. G. ; Liu, W. B. ; Liu, Y. Z. ; Li, D. W C. / Regulation of eye development by Protein serine/threonine phosphatases-1 and -2A. In: Current Molecular Medicine. 2015 ; Vol. 15, No. 10. pp. 944-951.
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