Regulation of dendrite and spine morphogenesis and plasticity by catenins

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

The appropriate regulation of dendrite, spine, and synapse morphogenesis in neurons both during and after development is critical for the formation and maintenance of neural circuits. It is becomingly increasingly clear that the cadherin-catenin cell adhesion complex, a complex that has been widely studied in epithelia, regulates neuronal morphogenesis. More interestingly, the catenins, cytosolic proteins that bind to cadherins, regulate multiple aspects of neuronal morphogenesis including dendrite, spine, and synapse morphogenesis and plasticity, both independent of and dependent on their ability to bind cadherins. In this review, we examine some of the more recent and exciting studies that implicate individual catenins in various aspects of neuronal morphogenesis and plasticity.

Original languageEnglish (US)
Pages (from-to)46-54
Number of pages9
JournalMolecular Neurobiology
Volume40
Issue number1
DOIs
StatePublished - Aug 2009

Fingerprint

Catenins
Dendrites
Morphogenesis
Spine
Cadherins
Synapses
Neuronal Plasticity
Cell Adhesion
Epithelium
Maintenance
Neurons

Keywords

  • Catenins
  • Dendrite
  • Neurons
  • Plasticity
  • Spine
  • Synapse

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience

Cite this

Regulation of dendrite and spine morphogenesis and plasticity by catenins. / Arikkath, Jyothi.

In: Molecular Neurobiology, Vol. 40, No. 1, 08.2009, p. 46-54.

Research output: Contribution to journalReview article

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