Regional variations in NMDA receptor downregulation in streptozotocin-diabetic rat brain

Le Don Bean, Hong Zheng, Kaushik P. Patel, Daniel T. Monaghan

Research output: Contribution to journalArticle

7 Scopus citations


Insulin insufficiency has multiple actions on the CNS. Three weeks after streptozotocin-induced diabetes in rats, we found a preferential downregulation of l-[3H]glutamate-labeled NMDA receptors in primary sensory cortical regions. Layers I-III of the parietal cortex and superficial piriform cortex were the most sensitive followed by other cortical regions and, in turn, deeper brain structures. These effects on NMDA receptors can potentially explain some of the known CNS effects of diabetes.

Original languageEnglish (US)
Pages (from-to)217-222
Number of pages6
JournalBrain Research
Issue number1
Publication statusPublished - Oct 18 2006


ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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