Regional responses of rat brain to impactor parameters

Yi Hua, Praveen Akula, Matthew Kelso, Linxia Gu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The closed head impact (CHI) rat models are commonly used for studying the traumatic brain injury. Although various impact parameters (e.g., impact depth, velocity, and position) have been investigated by a number of researchers, little is known about the effects of the impactor shape, diameter, and material on the internal responses of the rat brain. In this work, numerical CHI experiments were conducted to investigate the sensitivities of intracranial responses to the impactor details such as impactor shape, diameter, and material. A 3D finite element rat head model with anatomical details was subjected to impact loadings. Results revealed that the impactor shape can affect the intracranial responses significantly. The effect of impactor diameter on the intracranial responses in different brain regions was uniform. In addition, careful attention should be paid when using an extremely compliant material for the impactor, since the actual impact depth might be compensated by the impactor deformation.

Original languageEnglish (US)
Title of host publication17th International Conference on Advanced Vehicle Technologies; 12th International Conference on Design Education; 8th Frontiers in Biomedical Devices
PublisherAmerican Society of Mechanical Engineers (ASME)
ISBN (Electronic)9780791857106
DOIs
StatePublished - Jan 1 2015
EventASME 2015 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2015 - Boston, United States
Duration: Aug 2 2015Aug 5 2015

Publication series

NameProceedings of the ASME Design Engineering Technical Conference
Volume3

Other

OtherASME 2015 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2015
CountryUnited States
CityBoston
Period8/2/158/5/15

Fingerprint

Rats
Brain
Closed
Experiments
Finite Element
Internal
Model
Experiment

ASJC Scopus subject areas

  • Modeling and Simulation
  • Mechanical Engineering
  • Computer Science Applications
  • Computer Graphics and Computer-Aided Design

Cite this

Hua, Y., Akula, P., Kelso, M., & Gu, L. (2015). Regional responses of rat brain to impactor parameters. In 17th International Conference on Advanced Vehicle Technologies; 12th International Conference on Design Education; 8th Frontiers in Biomedical Devices (Proceedings of the ASME Design Engineering Technical Conference; Vol. 3). American Society of Mechanical Engineers (ASME). https://doi.org/10.1115/DETC2015-47373

Regional responses of rat brain to impactor parameters. / Hua, Yi; Akula, Praveen; Kelso, Matthew; Gu, Linxia.

17th International Conference on Advanced Vehicle Technologies; 12th International Conference on Design Education; 8th Frontiers in Biomedical Devices. American Society of Mechanical Engineers (ASME), 2015. (Proceedings of the ASME Design Engineering Technical Conference; Vol. 3).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hua, Y, Akula, P, Kelso, M & Gu, L 2015, Regional responses of rat brain to impactor parameters. in 17th International Conference on Advanced Vehicle Technologies; 12th International Conference on Design Education; 8th Frontiers in Biomedical Devices. Proceedings of the ASME Design Engineering Technical Conference, vol. 3, American Society of Mechanical Engineers (ASME), ASME 2015 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2015, Boston, United States, 8/2/15. https://doi.org/10.1115/DETC2015-47373
Hua Y, Akula P, Kelso M, Gu L. Regional responses of rat brain to impactor parameters. In 17th International Conference on Advanced Vehicle Technologies; 12th International Conference on Design Education; 8th Frontiers in Biomedical Devices. American Society of Mechanical Engineers (ASME). 2015. (Proceedings of the ASME Design Engineering Technical Conference). https://doi.org/10.1115/DETC2015-47373
Hua, Yi ; Akula, Praveen ; Kelso, Matthew ; Gu, Linxia. / Regional responses of rat brain to impactor parameters. 17th International Conference on Advanced Vehicle Technologies; 12th International Conference on Design Education; 8th Frontiers in Biomedical Devices. American Society of Mechanical Engineers (ASME), 2015. (Proceedings of the ASME Design Engineering Technical Conference).
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