Abstract
The relationship of the cellular changes in the HIV-infected brain to the onset and progression of AIDS dementia complex (ADC) remains uncertain. We undertook an in vivo proton magnetic resonance spectroscopy (MRS) study and used factor analysis to identify specific cellular and regional brain changes that may serve as metabolic markers of ADC. The ratio of N-acetyl aspartate (NAA), choline (Cho), and myoinositol (MI) over creatine (Cr), markers of neuronal and glial cell metabolism, were measured in the basal ganglia, centrum semiovale, and parietal cortex from 100 subjects with and without ADC. Three metabolic patterns were identified, which we termed "inflammatory" (mainly MI/Cr elevations in all three regions plus Cho/Cr increases in the centrum semiovale and parietal cortex), "basal ganglia" (mostly NAA/Cr and Cho/Cr elevations in the basal ganglia), and "neuronal" (primarily NAA/Cr reductions in the centrum semiovale and the parietal cortex). Logistic regression analysis revealed that, adjusted for age, basal ganglia and neuronal pattern scores were strongly associated with ADC but inflammatory levels were not. We conclude that by using factor analysis, we are able to combine multiple metabolites across brain regions in a biologically plausible manner and construct a predictive model of ADC adjusting for relevant factors such as age.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 928-935 |
| Number of pages | 8 |
| Journal | NeuroImage |
| Volume | 23 |
| Issue number | 3 |
| DOIs | |
| State | Published - Nov 1 2004 |
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Keywords
- AIDS
- Brain metabolism
- Factor analysis
- HIV dementia
- MRS
ASJC Scopus subject areas
- Neurology
- Cognitive Neuroscience
Cite this
Regional patterns of brain metabolites in AIDS dementia complex. / Yiannoutsos, Constantin T.; Ernst, Thomas; Chang, Linda; Lee, P. Lani; Richards, Todd; Marra, Christina M.; Meyerhoff, Dieter J.; Jarvik, Jeffrey G.; Kolson, Dennis; Schifitto, Giovanni; Ellis, Ronald J.; Swindells, Susan; Simpson, David M.; Miller, Eric N.; Gonzalez, R. Gilberto; Navia, Bradford A.
In: NeuroImage, Vol. 23, No. 3, 01.11.2004, p. 928-935.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regional patterns of brain metabolites in AIDS dementia complex
AU - Yiannoutsos, Constantin T.
AU - Ernst, Thomas
AU - Chang, Linda
AU - Lee, P. Lani
AU - Richards, Todd
AU - Marra, Christina M.
AU - Meyerhoff, Dieter J.
AU - Jarvik, Jeffrey G.
AU - Kolson, Dennis
AU - Schifitto, Giovanni
AU - Ellis, Ronald J.
AU - Swindells, Susan
AU - Simpson, David M.
AU - Miller, Eric N.
AU - Gonzalez, R. Gilberto
AU - Navia, Bradford A.
PY - 2004/11/1
Y1 - 2004/11/1
N2 - The relationship of the cellular changes in the HIV-infected brain to the onset and progression of AIDS dementia complex (ADC) remains uncertain. We undertook an in vivo proton magnetic resonance spectroscopy (MRS) study and used factor analysis to identify specific cellular and regional brain changes that may serve as metabolic markers of ADC. The ratio of N-acetyl aspartate (NAA), choline (Cho), and myoinositol (MI) over creatine (Cr), markers of neuronal and glial cell metabolism, were measured in the basal ganglia, centrum semiovale, and parietal cortex from 100 subjects with and without ADC. Three metabolic patterns were identified, which we termed "inflammatory" (mainly MI/Cr elevations in all three regions plus Cho/Cr increases in the centrum semiovale and parietal cortex), "basal ganglia" (mostly NAA/Cr and Cho/Cr elevations in the basal ganglia), and "neuronal" (primarily NAA/Cr reductions in the centrum semiovale and the parietal cortex). Logistic regression analysis revealed that, adjusted for age, basal ganglia and neuronal pattern scores were strongly associated with ADC but inflammatory levels were not. We conclude that by using factor analysis, we are able to combine multiple metabolites across brain regions in a biologically plausible manner and construct a predictive model of ADC adjusting for relevant factors such as age.
AB - The relationship of the cellular changes in the HIV-infected brain to the onset and progression of AIDS dementia complex (ADC) remains uncertain. We undertook an in vivo proton magnetic resonance spectroscopy (MRS) study and used factor analysis to identify specific cellular and regional brain changes that may serve as metabolic markers of ADC. The ratio of N-acetyl aspartate (NAA), choline (Cho), and myoinositol (MI) over creatine (Cr), markers of neuronal and glial cell metabolism, were measured in the basal ganglia, centrum semiovale, and parietal cortex from 100 subjects with and without ADC. Three metabolic patterns were identified, which we termed "inflammatory" (mainly MI/Cr elevations in all three regions plus Cho/Cr increases in the centrum semiovale and parietal cortex), "basal ganglia" (mostly NAA/Cr and Cho/Cr elevations in the basal ganglia), and "neuronal" (primarily NAA/Cr reductions in the centrum semiovale and the parietal cortex). Logistic regression analysis revealed that, adjusted for age, basal ganglia and neuronal pattern scores were strongly associated with ADC but inflammatory levels were not. We conclude that by using factor analysis, we are able to combine multiple metabolites across brain regions in a biologically plausible manner and construct a predictive model of ADC adjusting for relevant factors such as age.
KW - AIDS
KW - Brain metabolism
KW - Factor analysis
KW - HIV dementia
KW - MRS
UR - http://www.scopus.com/inward/record.url?scp=7544251428&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=7544251428&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2004.07.033
DO - 10.1016/j.neuroimage.2004.07.033
M3 - Article
C2 - 15528093
AN - SCOPUS:7544251428
VL - 23
SP - 928
EP - 935
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
IS - 3
ER -