Regional distribution of emphysema

Correlation of high-resolution CT with pulmonary function tests in unselected smokers

Jud W. Gurney, Karen K. Jones, Richard A. Robbins, Gail L. Gossman, Kenneth J. Nelson, David Daughton, John R. Spurzem, Stephen Israel Rennard

Research output: Contribution to journalArticle

160 Citations (Scopus)

Abstract

High-resolution computed tomography (CT) was correlated with pulmonary function tests in the evaluation of regional emphysema in 59 smokers. The lung was divided into upper (above the carina tracheae) and lower (below the carina tracheae) zones, and the degree of emphysema was graded with a subjective and an objective measurement. Functional emphysema was defined as a diffusion capacity less than 75% of predicted and forced expiratory volume in 1 second less than 80% of predicted. Three of 15 (20%) subjects with functional emphysema had no subjective evidence of emphysema at high-resolution CT, and 10 of 25 (40%) with emphysema at high-resolution CT had no functional abnormalities consistent with emphysema. Even though the upper lung zones were more severely affected by emphysema, the degree of emphysema in the lower zones had a stronger correlation with pulmonary function abnormalities. The upper lung zones are a relatively silent region where extensive destruction may occur before functional abnormalities become known.

Original languageEnglish (US)
Pages (from-to)457-463
Number of pages7
JournalRadiology
Volume183
Issue number2
DOIs
StatePublished - Jan 1 1992

Fingerprint

Respiratory Function Tests
Emphysema
Tomography
Lung
Trachea
Forced Expiratory Volume

Keywords

  • Computed tomography (CT), high-resolution
  • Emphysema, pulmonary, 60.751
  • Lung, CT, 60.1211

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Gurney, J. W., Jones, K. K., Robbins, R. A., Gossman, G. L., Nelson, K. J., Daughton, D., ... Rennard, S. I. (1992). Regional distribution of emphysema: Correlation of high-resolution CT with pulmonary function tests in unselected smokers. Radiology, 183(2), 457-463. https://doi.org/10.1148/radiology.183.2.1561350

Regional distribution of emphysema : Correlation of high-resolution CT with pulmonary function tests in unselected smokers. / Gurney, Jud W.; Jones, Karen K.; Robbins, Richard A.; Gossman, Gail L.; Nelson, Kenneth J.; Daughton, David; Spurzem, John R.; Rennard, Stephen Israel.

In: Radiology, Vol. 183, No. 2, 01.01.1992, p. 457-463.

Research output: Contribution to journalArticle

Gurney, JW, Jones, KK, Robbins, RA, Gossman, GL, Nelson, KJ, Daughton, D, Spurzem, JR & Rennard, SI 1992, 'Regional distribution of emphysema: Correlation of high-resolution CT with pulmonary function tests in unselected smokers', Radiology, vol. 183, no. 2, pp. 457-463. https://doi.org/10.1148/radiology.183.2.1561350
Gurney, Jud W. ; Jones, Karen K. ; Robbins, Richard A. ; Gossman, Gail L. ; Nelson, Kenneth J. ; Daughton, David ; Spurzem, John R. ; Rennard, Stephen Israel. / Regional distribution of emphysema : Correlation of high-resolution CT with pulmonary function tests in unselected smokers. In: Radiology. 1992 ; Vol. 183, No. 2. pp. 457-463.
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