Regional distribution and ionic requirement of Cl-/Ca2+-activated and Cl-/Ca2+-independent glutamate receptors in rat brain

Scott R. Whittemore, E. Edward Mena, Daniel T. Monaghan, Carl W. Cotman

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Recent studies have shown that Cl- and Ca2+ ions increase [3H]glutamate binding to rat forebrain synaptic plasma membranes by expressing a new class of glutamate receptors. We examined the regional distribution of these two classes of glutamate binding sites and further characterized their ionic requirements. Significant differences in both Cl-/Ca2+-independent (basal) and Cl-/Ca2+-activated receptors, as well as the ratios of these two receptor classes were observed among different areas of the CNS. Cl- and Ca2+ appeared to act synergistically, with Cl- ion an absolute requirement for Ca2+ stimulation, in expressing these additional binding sites. Ca2+ alone did not affect glutamate binding.

Original languageEnglish (US)
Pages (from-to)99-107
Number of pages9
JournalBrain Research
Volume277
Issue number1
DOIs
StatePublished - Oct 24 1983

Fingerprint

Glutamate Receptors
Glutamic Acid
Brain
Binding Sites
Ions
Synaptic Membranes
Prosencephalon
Cell Membrane

Keywords

  • 2-amino-4-phosphonobutyrate
  • Cl/Ca-activated glutamate receptors
  • cerebellum
  • spinal cord

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Regional distribution and ionic requirement of Cl-/Ca2+-activated and Cl-/Ca2+-independent glutamate receptors in rat brain. / Whittemore, Scott R.; Edward Mena, E.; Monaghan, Daniel T.; Cotman, Carl W.

In: Brain Research, Vol. 277, No. 1, 24.10.1983, p. 99-107.

Research output: Contribution to journalArticle

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