Reduction of contact factors in sickle cell disease

Erlinda M. Gordon, Bruce L. Klein, Brian W. Berman, Sarh E. Strandjord, Joseph E. Simon, Peter Felix Coccia

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Surface-mediated reactions of clotting were compared in 21 black children with homozygous sickle cell disease, 12 age-matched controls, and 15 adults. Both the coagulant and antigen titers of Hageman factor (factor XII) were decreased in asymptomatic patients compared with those in the control groups. These findings were associated with slight but significant reduction in the plasma titers of prekallikrein and high molecular weight kininogen. A further decrease from the initially low titers of these contact factors was observed during vaso-occlusive crises. Additionally, we observed a disparate relationship between Hageman factor coagulant activity and its antigen titers. These data provide evidence for reduction of the contact factors in patients with homozygous sickle cell disease.

Original languageEnglish (US)
Pages (from-to)427-430
Number of pages4
JournalThe Journal of Pediatrics
Volume106
Issue number3
DOIs
StatePublished - Jan 1 1985

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Factor XII
Sickle Cell Anemia
Coagulants
High Molecular Weight Kininogens
Prekallikrein
Antigens
Control Groups

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Gordon, E. M., Klein, B. L., Berman, B. W., Strandjord, S. E., Simon, J. E., & Coccia, P. F. (1985). Reduction of contact factors in sickle cell disease. The Journal of Pediatrics, 106(3), 427-430. https://doi.org/10.1016/S0022-3476(85)80669-7

Reduction of contact factors in sickle cell disease. / Gordon, Erlinda M.; Klein, Bruce L.; Berman, Brian W.; Strandjord, Sarh E.; Simon, Joseph E.; Coccia, Peter Felix.

In: The Journal of Pediatrics, Vol. 106, No. 3, 01.01.1985, p. 427-430.

Research output: Contribution to journalArticle

Gordon, EM, Klein, BL, Berman, BW, Strandjord, SE, Simon, JE & Coccia, PF 1985, 'Reduction of contact factors in sickle cell disease', The Journal of Pediatrics, vol. 106, no. 3, pp. 427-430. https://doi.org/10.1016/S0022-3476(85)80669-7
Gordon EM, Klein BL, Berman BW, Strandjord SE, Simon JE, Coccia PF. Reduction of contact factors in sickle cell disease. The Journal of Pediatrics. 1985 Jan 1;106(3):427-430. https://doi.org/10.1016/S0022-3476(85)80669-7
Gordon, Erlinda M. ; Klein, Bruce L. ; Berman, Brian W. ; Strandjord, Sarh E. ; Simon, Joseph E. ; Coccia, Peter Felix. / Reduction of contact factors in sickle cell disease. In: The Journal of Pediatrics. 1985 ; Vol. 106, No. 3. pp. 427-430.
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