Reduction in mammary tumorigenesis in the rat by cabbage and cabbage residue

Edward Bresnick, D. F. Birt, K. Wolterman, Maureen Wheeler, Rodney Smith Markin

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Mammary cancer was induced in female Sprague-Dawley rats by a single injection of N-methyl-N-nitrosourea (MNU) and rats were randomized to control fat (5%) and high fat (24.6%) diets. un addition, dried cabbage (5 and 10%) and collards (5%) were included in the diets of some animals. No statistically significant differences were observed in food consumption, body wt gain and caloric intake between the MNU-treated and control groups in the rats fed the low-fat diet. However, the groups fed the high-fat diet consumed more than the rats maintained on the control diet. The rats on the control fat diet containing cabbage exhibited a significantly lower incidence of mammary cancer than rats that were fed the control-fat diet without cabbage. This effect was not observed in comparable rats on the high-fat diet. The inhibitory effect on mammary tumorigenesis was demonstrated using a residue obtained from cabbage by exhaustive extraction with methanol, methylene chloride and petroleum ether. These studies reinforce the efficacy of cabbage as a 'suppressor' of cancer in experimental model systems under control-fat dietary conditions.

Original languageEnglish (US)
Pages (from-to)1159-1163
Number of pages5
JournalCarcinogenesis
Volume11
Issue number7
DOIs
StatePublished - Jul 1 1990

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Brassica
Carcinogenesis
Breast
High Fat Diet
Diet
Fats
Breast Neoplasms
Methylnitrosourea
Fat-Restricted Diet
Dietary Fats
Methylene Chloride
Energy Intake
Sprague Dawley Rats
Methanol
Theoretical Models
Food
Control Groups
Injections
Incidence
Neoplasms

ASJC Scopus subject areas

  • Cancer Research

Cite this

Reduction in mammary tumorigenesis in the rat by cabbage and cabbage residue. / Bresnick, Edward; Birt, D. F.; Wolterman, K.; Wheeler, Maureen; Markin, Rodney Smith.

In: Carcinogenesis, Vol. 11, No. 7, 01.07.1990, p. 1159-1163.

Research output: Contribution to journalArticle

Bresnick, Edward ; Birt, D. F. ; Wolterman, K. ; Wheeler, Maureen ; Markin, Rodney Smith. / Reduction in mammary tumorigenesis in the rat by cabbage and cabbage residue. In: Carcinogenesis. 1990 ; Vol. 11, No. 7. pp. 1159-1163.
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