Reduction in mammary tumorigenesis in the rat by cabbage and cabbage residue

Edward Bresnick, D. F. Birt, K. Wolterman, Maureen Wheeler, R. S. Markin

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Abstract

Mammary cancer was induced in female Sprague-Dawley rats by a single injection of N-methyl-N-nitrosourea (MNU) and rats were randomized to control fat (5%) and high fat (24.6%) diets. un addition, dried cabbage (5 and 10%) and collards (5%) were included in the diets of some animals. No statistically significant differences were observed in food consumption, body wt gain and caloric intake between the MNU-treated and control groups in the rats fed the low-fat diet. However, the groups fed the high-fat diet consumed more than the rats maintained on the control diet. The rats on the control fat diet containing cabbage exhibited a significantly lower incidence of mammary cancer than rats that were fed the control-fat diet without cabbage. This effect was not observed in comparable rats on the high-fat diet. The inhibitory effect on mammary tumorigenesis was demonstrated using a residue obtained from cabbage by exhaustive extraction with methanol, methylene chloride and petroleum ether. These studies reinforce the efficacy of cabbage as a 'suppressor' of cancer in experimental model systems under control-fat dietary conditions.

Original languageEnglish (US)
Pages (from-to)1159-1163
Number of pages5
JournalCarcinogenesis
Volume11
Issue number7
DOIs
StatePublished - Jul 1 1990

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ASJC Scopus subject areas

  • Cancer Research

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