Reduced growth hormone secretion in turner syndrome: Is body weight a key factor?

Stefano Cianfarani, Fabrizio Vaccaro, Anna Maria Pasquino, Sabatino A. Marchione, Franca Passeri, Gian Luigi Spadoni, Sergio Bernardini, Anna Spagnoli, Brunetto Boscherini

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The age-related decline in spontaneous growth hormone (GH) secretion has been suggested to cause growth failure in girls with Turner syndrome (TS). We studied 23 girls (mean age ± SD: 11.1 ± 2.7 years) diagnosed to have TS by karyotype analysis. The control group consisted of 18 prepubertal age- matched subjects (10.7 ± 2.5 years) with growth retardation due to familial short stature and/or constitutional growth delay. In addition, 18 children (10.9 ± 3.3 years) diagnosed to have GH deficiency by two different provocative tests were chosen as a further comparison group. Spontaneous 12-hour nocturnal GH secretion was assessed by RIA at 30-min intervals. Plasma insulin-like growth factor 1 (IGF-1) levels were determined by RIA after acid-ethanol extraction. Girls with TS had a percentage of ideal body weight significantly higher than controls (p < 0.0001) and showed spontaneous GH secretion significantly lower than controls (mean ± SD: 3.2 ± 1.6 in TS vs. 5.5 ± 1.3 μg/l in controls; p < 0.0001) but higher than GH-deficient patients (1.3 ± 0.8 μg/1; p < 0.0001). No significant difference was found in IGF-1 levels between TS patients and controls, whereas GH-deficient children showed IGF-1 levels significantly lower than those of TS patients (p < 0.0005). As expected, GH concentrations correlated with bone age in controls (r = 0.51, p < 0.05), whereas no relationship was seen in TS. Interestingly, in TS, GH levels were negatively related to the percentage of ideal body weight (r = -0.43, p < 0.05). The finding of GH levels intermediate between control and GH-deficient patients together with normal IGF-1 concentrations, questions the existence of a ‘classical’ GH insufficiency in TS girls. This study confirms that weight excess is a common feature of TS girls at pubertal age and suggests that the reduced GH secretion might be due, at least in part, to obesity.

Original languageEnglish (US)
Pages (from-to)27-32
Number of pages6
JournalHormone Research in Paediatrics
Volume41
Issue number1
DOIs
StatePublished - Jan 1 1994

Fingerprint

Turner Syndrome
Growth Hormone
Body Weight
Somatomedins
Ideal Body Weight
Growth
Karyotype
Ethanol
Obesity

Keywords

  • Growth hormone
  • Insulin-like growth factor
  • Obesity
  • Turner syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Cianfarani, S., Vaccaro, F., Pasquino, A. M., Marchione, S. A., Passeri, F., Spadoni, G. L., ... Boscherini, B. (1994). Reduced growth hormone secretion in turner syndrome: Is body weight a key factor? Hormone Research in Paediatrics, 41(1), 27-32. https://doi.org/10.1159/000183873

Reduced growth hormone secretion in turner syndrome : Is body weight a key factor? / Cianfarani, Stefano; Vaccaro, Fabrizio; Pasquino, Anna Maria; Marchione, Sabatino A.; Passeri, Franca; Spadoni, Gian Luigi; Bernardini, Sergio; Spagnoli, Anna; Boscherini, Brunetto.

In: Hormone Research in Paediatrics, Vol. 41, No. 1, 01.01.1994, p. 27-32.

Research output: Contribution to journalArticle

Cianfarani, S, Vaccaro, F, Pasquino, AM, Marchione, SA, Passeri, F, Spadoni, GL, Bernardini, S, Spagnoli, A & Boscherini, B 1994, 'Reduced growth hormone secretion in turner syndrome: Is body weight a key factor?', Hormone Research in Paediatrics, vol. 41, no. 1, pp. 27-32. https://doi.org/10.1159/000183873
Cianfarani S, Vaccaro F, Pasquino AM, Marchione SA, Passeri F, Spadoni GL et al. Reduced growth hormone secretion in turner syndrome: Is body weight a key factor? Hormone Research in Paediatrics. 1994 Jan 1;41(1):27-32. https://doi.org/10.1159/000183873
Cianfarani, Stefano ; Vaccaro, Fabrizio ; Pasquino, Anna Maria ; Marchione, Sabatino A. ; Passeri, Franca ; Spadoni, Gian Luigi ; Bernardini, Sergio ; Spagnoli, Anna ; Boscherini, Brunetto. / Reduced growth hormone secretion in turner syndrome : Is body weight a key factor?. In: Hormone Research in Paediatrics. 1994 ; Vol. 41, No. 1. pp. 27-32.
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