Reduced basal ganglia volumes in trichotillomania measured via morphometric magnetic resonance imaging

Richard L. O'Sullivan, Scott L. Rauch, Hans C. Breiter, Igor D. Grachev, Lee Baer, David N. Kennedy, Nancy J. Keuthen, Cary R. Savage, Peter A. Manzo, Verne S. Caviness, Michael A. Jenike

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

A morphometric magnetic resonance imaging (MRI) study compared volumes of brain structures in 10 female subjects with trichotillomania (repetitive hair-pulling) versus 10 normal controls matched for sex, age, handedness, and education. Three-dimensional MRI scans were blindly normalized and segmented using well-characterized semiautomated intensity and differential contour algorithms by signal intensity-frequency histograms. Consistent with one a priori hypothesis, left putamen volume was found to be significantly smaller in trichotillomania subjects as compared with normal matched controls. This is the first report of a structural brain abnormality in trichotillomania. Results are discussed in terms of putative relationships between trichotillomania, Tourette's syndrome, and obsessive-compulsive disorder.

Original languageEnglish (US)
Pages (from-to)39-45
Number of pages7
JournalBiological Psychiatry
Volume42
Issue number1
DOIs
StatePublished - Jul 1 1997

Fingerprint

Trichotillomania
Basal Ganglia
Magnetic Resonance Imaging
Tourette Syndrome
Functional Laterality
Putamen
Obsessive-Compulsive Disorder
Brain
Education

Keywords

  • Basal ganglia
  • Morphometric magnetic resonance imaging
  • Trichotillomania
  • putamen

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

O'Sullivan, R. L., Rauch, S. L., Breiter, H. C., Grachev, I. D., Baer, L., Kennedy, D. N., ... Jenike, M. A. (1997). Reduced basal ganglia volumes in trichotillomania measured via morphometric magnetic resonance imaging. Biological Psychiatry, 42(1), 39-45. https://doi.org/10.1016/S0006-3223(96)00297-1

Reduced basal ganglia volumes in trichotillomania measured via morphometric magnetic resonance imaging. / O'Sullivan, Richard L.; Rauch, Scott L.; Breiter, Hans C.; Grachev, Igor D.; Baer, Lee; Kennedy, David N.; Keuthen, Nancy J.; Savage, Cary R.; Manzo, Peter A.; Caviness, Verne S.; Jenike, Michael A.

In: Biological Psychiatry, Vol. 42, No. 1, 01.07.1997, p. 39-45.

Research output: Contribution to journalArticle

O'Sullivan, RL, Rauch, SL, Breiter, HC, Grachev, ID, Baer, L, Kennedy, DN, Keuthen, NJ, Savage, CR, Manzo, PA, Caviness, VS & Jenike, MA 1997, 'Reduced basal ganglia volumes in trichotillomania measured via morphometric magnetic resonance imaging', Biological Psychiatry, vol. 42, no. 1, pp. 39-45. https://doi.org/10.1016/S0006-3223(96)00297-1
O'Sullivan, Richard L. ; Rauch, Scott L. ; Breiter, Hans C. ; Grachev, Igor D. ; Baer, Lee ; Kennedy, David N. ; Keuthen, Nancy J. ; Savage, Cary R. ; Manzo, Peter A. ; Caviness, Verne S. ; Jenike, Michael A. / Reduced basal ganglia volumes in trichotillomania measured via morphometric magnetic resonance imaging. In: Biological Psychiatry. 1997 ; Vol. 42, No. 1. pp. 39-45.
@article{0e98751150d947e3b9c0e88ea61ae5c7,
title = "Reduced basal ganglia volumes in trichotillomania measured via morphometric magnetic resonance imaging",
abstract = "A morphometric magnetic resonance imaging (MRI) study compared volumes of brain structures in 10 female subjects with trichotillomania (repetitive hair-pulling) versus 10 normal controls matched for sex, age, handedness, and education. Three-dimensional MRI scans were blindly normalized and segmented using well-characterized semiautomated intensity and differential contour algorithms by signal intensity-frequency histograms. Consistent with one a priori hypothesis, left putamen volume was found to be significantly smaller in trichotillomania subjects as compared with normal matched controls. This is the first report of a structural brain abnormality in trichotillomania. Results are discussed in terms of putative relationships between trichotillomania, Tourette's syndrome, and obsessive-compulsive disorder.",
keywords = "Basal ganglia, Morphometric magnetic resonance imaging, Trichotillomania, putamen",
author = "O'Sullivan, {Richard L.} and Rauch, {Scott L.} and Breiter, {Hans C.} and Grachev, {Igor D.} and Lee Baer and Kennedy, {David N.} and Keuthen, {Nancy J.} and Savage, {Cary R.} and Manzo, {Peter A.} and Caviness, {Verne S.} and Jenike, {Michael A.}",
year = "1997",
month = "7",
day = "1",
doi = "10.1016/S0006-3223(96)00297-1",
language = "English (US)",
volume = "42",
pages = "39--45",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "1",

}

TY - JOUR

T1 - Reduced basal ganglia volumes in trichotillomania measured via morphometric magnetic resonance imaging

AU - O'Sullivan, Richard L.

AU - Rauch, Scott L.

AU - Breiter, Hans C.

AU - Grachev, Igor D.

AU - Baer, Lee

AU - Kennedy, David N.

AU - Keuthen, Nancy J.

AU - Savage, Cary R.

AU - Manzo, Peter A.

AU - Caviness, Verne S.

AU - Jenike, Michael A.

PY - 1997/7/1

Y1 - 1997/7/1

N2 - A morphometric magnetic resonance imaging (MRI) study compared volumes of brain structures in 10 female subjects with trichotillomania (repetitive hair-pulling) versus 10 normal controls matched for sex, age, handedness, and education. Three-dimensional MRI scans were blindly normalized and segmented using well-characterized semiautomated intensity and differential contour algorithms by signal intensity-frequency histograms. Consistent with one a priori hypothesis, left putamen volume was found to be significantly smaller in trichotillomania subjects as compared with normal matched controls. This is the first report of a structural brain abnormality in trichotillomania. Results are discussed in terms of putative relationships between trichotillomania, Tourette's syndrome, and obsessive-compulsive disorder.

AB - A morphometric magnetic resonance imaging (MRI) study compared volumes of brain structures in 10 female subjects with trichotillomania (repetitive hair-pulling) versus 10 normal controls matched for sex, age, handedness, and education. Three-dimensional MRI scans were blindly normalized and segmented using well-characterized semiautomated intensity and differential contour algorithms by signal intensity-frequency histograms. Consistent with one a priori hypothesis, left putamen volume was found to be significantly smaller in trichotillomania subjects as compared with normal matched controls. This is the first report of a structural brain abnormality in trichotillomania. Results are discussed in terms of putative relationships between trichotillomania, Tourette's syndrome, and obsessive-compulsive disorder.

KW - Basal ganglia

KW - Morphometric magnetic resonance imaging

KW - Trichotillomania

KW - putamen

UR - http://www.scopus.com/inward/record.url?scp=18344407774&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18344407774&partnerID=8YFLogxK

U2 - 10.1016/S0006-3223(96)00297-1

DO - 10.1016/S0006-3223(96)00297-1

M3 - Article

C2 - 9193740

AN - SCOPUS:18344407774

VL - 42

SP - 39

EP - 45

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 1

ER -