Reduced amygdala-orbitofrontal connectivity during moral judgments in youths with disruptive behavior disorders and psychopathic traits

Abigail A. Marsh, Elizabeth C. Finger, Katherine A. Fowler, Ilana T.N. Jurkowitz, Julia C. Schechter, Henry H. Yu, Daniel S. Pine, R. J.R. Blair

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

We used functional magnetic resonance imaging (fMRI) to investigate dysfunction in the amygdala and orbitofrontal cortex in adolescents with disruptive behavior disorders and psychopathic traits during a moral judgment task. Fourteen adolescents with psychopathic traits and 14 healthy controls were assessed using fMRI while they categorized illegal and legal behaviors in a moral judgment implicit association task. fMRI data were then analyzed using random-effects analysis of variance and functional connectivity. Youths with psychopathic traits showed reduced amygdala activity when making judgments about legal actions and reduced functional connectivity between the amygdala and orbitofrontal cortex during task performance. These results suggest that psychopathic traits are associated with amygdala and orbitofrontal cortex dysfunction. This dysfunction may relate to previous findings of disrupted moral judgment in this population.

Original languageEnglish (US)
Pages (from-to)279-286
Number of pages8
JournalPsychiatry Research - Neuroimaging
Volume194
Issue number3
DOIs
StatePublished - Dec 30 2011

Fingerprint

Attention Deficit and Disruptive Behavior Disorders
Amygdala
Prefrontal Cortex
Magnetic Resonance Imaging
Task Performance and Analysis
Analysis of Variance
Population

Keywords

  • Conduct disorder
  • FMRI
  • Moral reasoning
  • Psychopathy

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

Cite this

Reduced amygdala-orbitofrontal connectivity during moral judgments in youths with disruptive behavior disorders and psychopathic traits. / Marsh, Abigail A.; Finger, Elizabeth C.; Fowler, Katherine A.; Jurkowitz, Ilana T.N.; Schechter, Julia C.; Yu, Henry H.; Pine, Daniel S.; Blair, R. J.R.

In: Psychiatry Research - Neuroimaging, Vol. 194, No. 3, 30.12.2011, p. 279-286.

Research output: Contribution to journalArticle

Marsh, Abigail A. ; Finger, Elizabeth C. ; Fowler, Katherine A. ; Jurkowitz, Ilana T.N. ; Schechter, Julia C. ; Yu, Henry H. ; Pine, Daniel S. ; Blair, R. J.R. / Reduced amygdala-orbitofrontal connectivity during moral judgments in youths with disruptive behavior disorders and psychopathic traits. In: Psychiatry Research - Neuroimaging. 2011 ; Vol. 194, No. 3. pp. 279-286.
@article{808e22248cd341a9b8c28d1d08820672,
title = "Reduced amygdala-orbitofrontal connectivity during moral judgments in youths with disruptive behavior disorders and psychopathic traits",
abstract = "We used functional magnetic resonance imaging (fMRI) to investigate dysfunction in the amygdala and orbitofrontal cortex in adolescents with disruptive behavior disorders and psychopathic traits during a moral judgment task. Fourteen adolescents with psychopathic traits and 14 healthy controls were assessed using fMRI while they categorized illegal and legal behaviors in a moral judgment implicit association task. fMRI data were then analyzed using random-effects analysis of variance and functional connectivity. Youths with psychopathic traits showed reduced amygdala activity when making judgments about legal actions and reduced functional connectivity between the amygdala and orbitofrontal cortex during task performance. These results suggest that psychopathic traits are associated with amygdala and orbitofrontal cortex dysfunction. This dysfunction may relate to previous findings of disrupted moral judgment in this population.",
keywords = "Conduct disorder, FMRI, Moral reasoning, Psychopathy",
author = "Marsh, {Abigail A.} and Finger, {Elizabeth C.} and Fowler, {Katherine A.} and Jurkowitz, {Ilana T.N.} and Schechter, {Julia C.} and Yu, {Henry H.} and Pine, {Daniel S.} and Blair, {R. J.R.}",
year = "2011",
month = "12",
day = "30",
doi = "10.1016/j.pscychresns.2011.07.008",
language = "English (US)",
volume = "194",
pages = "279--286",
journal = "Psychiatry Research - Neuroimaging",
issn = "0925-4927",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Reduced amygdala-orbitofrontal connectivity during moral judgments in youths with disruptive behavior disorders and psychopathic traits

AU - Marsh, Abigail A.

AU - Finger, Elizabeth C.

AU - Fowler, Katherine A.

AU - Jurkowitz, Ilana T.N.

AU - Schechter, Julia C.

AU - Yu, Henry H.

AU - Pine, Daniel S.

AU - Blair, R. J.R.

PY - 2011/12/30

Y1 - 2011/12/30

N2 - We used functional magnetic resonance imaging (fMRI) to investigate dysfunction in the amygdala and orbitofrontal cortex in adolescents with disruptive behavior disorders and psychopathic traits during a moral judgment task. Fourteen adolescents with psychopathic traits and 14 healthy controls were assessed using fMRI while they categorized illegal and legal behaviors in a moral judgment implicit association task. fMRI data were then analyzed using random-effects analysis of variance and functional connectivity. Youths with psychopathic traits showed reduced amygdala activity when making judgments about legal actions and reduced functional connectivity between the amygdala and orbitofrontal cortex during task performance. These results suggest that psychopathic traits are associated with amygdala and orbitofrontal cortex dysfunction. This dysfunction may relate to previous findings of disrupted moral judgment in this population.

AB - We used functional magnetic resonance imaging (fMRI) to investigate dysfunction in the amygdala and orbitofrontal cortex in adolescents with disruptive behavior disorders and psychopathic traits during a moral judgment task. Fourteen adolescents with psychopathic traits and 14 healthy controls were assessed using fMRI while they categorized illegal and legal behaviors in a moral judgment implicit association task. fMRI data were then analyzed using random-effects analysis of variance and functional connectivity. Youths with psychopathic traits showed reduced amygdala activity when making judgments about legal actions and reduced functional connectivity between the amygdala and orbitofrontal cortex during task performance. These results suggest that psychopathic traits are associated with amygdala and orbitofrontal cortex dysfunction. This dysfunction may relate to previous findings of disrupted moral judgment in this population.

KW - Conduct disorder

KW - FMRI

KW - Moral reasoning

KW - Psychopathy

UR - http://www.scopus.com/inward/record.url?scp=82455212996&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=82455212996&partnerID=8YFLogxK

U2 - 10.1016/j.pscychresns.2011.07.008

DO - 10.1016/j.pscychresns.2011.07.008

M3 - Article

C2 - 22047730

AN - SCOPUS:82455212996

VL - 194

SP - 279

EP - 286

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

SN - 0925-4927

IS - 3

ER -