Reduced activity within the dorsal endogenous orienting of attention network to fearful expressions in youth with disruptive behavior disorders and psychopathic traits

Stuart F. White, W. Craig Williams, Sarah J. Brislin, Stephen Sinclair, Karina S. Blair, Katherine A. Fowler, Daniel S. Pine, Kayla Pope, R. James Blair

Research output: Contribution to journalArticle

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Abstract

Using behavioral and blood oxygen level dependent (BOLD) response indices through functional magnetic resonance imaging (fMRI), the current study investigated whether youths with disruptive behavior disorders (conduct disorder and oppositional defiant disorder) plus psychopathic traits (DBD + PT) show aberrant sensitivity to eye gaze information generally and/or whether they show particular insensitivity to eye gaze information in the context of fearful expressions. The participants were 36 children and adolescents (ages 10a"17 years); 17 had DBD + PT and 19 were healthy comparison subjects. Participants performed a spatial attention paradigm where spatial attention was cued by eye gaze in faces displaying fearful, angry, or neutral affect. Eye gaze sensitivity was indexed both behaviorally and as BOLD response. There were no group differences in behavioral response: both groups showed significantly faster responses if the target was in the congruent spatial direction indicated by eye gaze. Neither group showed a Congruence A -Emotion interaction; neither group showed an advantage from the displayer's emotional expression behaviorally. However, the BOLD response revealed a significant Group A -Congruence A -Emotion interaction. The comparison youth showed increased activity within the dorsal endogenous orienting network (superior parietal lobule and inferior parietal sulcus) for fearful congruent relative to incongruent trials relative to the youth with DBD + PT. The results are discussed with reference to current models of DBD + PT and possible treatment innovations.

Original languageEnglish (US)
Pages (from-to)1105-1116
Number of pages12
JournalDevelopment and psychopathology
Volume24
Issue number3
DOIs
Publication statusPublished - Aug 1 2012

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ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

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