Redox regulation of motile cilia in airway disease

Michael E. Price, Joseph H. Sisson

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Motile cilia on airway cells are necessary for clearance of mucus-trapped particles out of the lung. Ciliated airway epithelial cells are uniquely exposed to oxidants through trapping of particles, debris and pathogens in mucus and the direct exposure to inhaled oxidant gases. Dynein ATPases, the motors driving ciliary motility, are sensitive to the local redox environment within each cilium. Several redox-sensitive cilia-localized proteins modulate dynein activity and include Protein Kinase A, Protein Kinase C, and Protein Phosphatase 1. Moreover, cilia are rich in known redox regulatory proteins and thioredoxin domain-containing proteins that are critical in maintaining a balanced redox environment. Importantly, a nonsense mutation in TXNDC3, which contains a thioredoxin motif, has recently been identified as disease-causing in Primary Ciliary Dyskinesia, a hereditary motile cilia disease resulting in impaired mucociliary clearance. Here we review current understanding of the role(s) oxidant species play in modifying airway ciliary function. We focus on oxidants generated in the airways, cilia redox targets that modulate ciliary beating and imbalances in redox state that impact health and disease. Finally, we review disease models such as smoking, asthma, alcohol drinking, and infections as well as the direct application of oxidants that implicate redox balance as a modulator of cilia motility.

Original languageEnglish (US)
Article number101146
JournalRedox Biology
Volume27
DOIs
StatePublished - Oct 2019

Fingerprint

Cilia
Oxidation-Reduction
Oxidants
Dyneins
Thioredoxins
Mucus
Bridge clearances
Kartagener Syndrome
Mucociliary Clearance
Protein Phosphatase 1
Proteins
Nonsense Codon
Pathogens
Cyclic AMP-Dependent Protein Kinases
Debris
Alcohol Drinking
Protein Kinase C
Modulators
Asthma
Gases

Keywords

  • Alcohol
  • Cilia
  • Hydrogen peroxide
  • Nitric oxide
  • Redox regulation
  • S-nitrosation
  • Superoxide

ASJC Scopus subject areas

  • Organic Chemistry
  • Clinical Biochemistry

Cite this

Redox regulation of motile cilia in airway disease. / Price, Michael E.; Sisson, Joseph H.

In: Redox Biology, Vol. 27, 101146, 10.2019.

Research output: Contribution to journalReview article

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