Redistribution of strain and curvature in the porcine anterior lens capsule following a continuous circular capsulorhexis

M. R. Heistand, R. M. Pedrigi, J. Dziezyc, J. D. Humphrey

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Cataract surgery is the most commonly performed surgical procedure in the US, it consists of three steps: introduction of a hole into the lens capsule, removal of the clouded lens through this access hole, and insertion of an artificial lens. We hypothesize that errant behavior by the residual epithelial cells of the lens capsule following surgery are due, in part, to surgically-induced changes of the native stress and strain fields in the lens capsule. Because the capsular bag can be regarded mechanically as a membrane, here we study changes in curvature and strains due to the most common means of introducing the initial access hole: a continuous circular capsulorhexis (CCC). We show that a modest sized CCC increases circumferential strains and decreases meridional strains by up to ∼20% and that curvatures change by up to ∼13%, particularly near the edge of the CCC. We submit that such changes can induce mechanobiological responses that are responsible, in part, for some of the long-term complications following cataract surgery.

Original languageEnglish (US)
Pages (from-to)1537-1542
Number of pages6
JournalJournal of Biomechanics
Volume39
Issue number8
DOIs
StatePublished - Aug 28 2006

Fingerprint

Anterior Capsule of the Lens
Capsulorhexis
Lenses
Swine
Surgery
Capsules
Cataract
Epithelial Cells
Membranes

Keywords

  • Accommodation
  • Biomechanics
  • Cataracts
  • Stiffness
  • Stress

ASJC Scopus subject areas

  • Biophysics
  • Orthopedics and Sports Medicine
  • Biomedical Engineering
  • Rehabilitation

Cite this

Redistribution of strain and curvature in the porcine anterior lens capsule following a continuous circular capsulorhexis. / Heistand, M. R.; Pedrigi, R. M.; Dziezyc, J.; Humphrey, J. D.

In: Journal of Biomechanics, Vol. 39, No. 8, 28.08.2006, p. 1537-1542.

Research output: Contribution to journalArticle

@article{19ad16f97e9d4eca9fc3ca6e4586f6bd,
title = "Redistribution of strain and curvature in the porcine anterior lens capsule following a continuous circular capsulorhexis",
abstract = "Cataract surgery is the most commonly performed surgical procedure in the US, it consists of three steps: introduction of a hole into the lens capsule, removal of the clouded lens through this access hole, and insertion of an artificial lens. We hypothesize that errant behavior by the residual epithelial cells of the lens capsule following surgery are due, in part, to surgically-induced changes of the native stress and strain fields in the lens capsule. Because the capsular bag can be regarded mechanically as a membrane, here we study changes in curvature and strains due to the most common means of introducing the initial access hole: a continuous circular capsulorhexis (CCC). We show that a modest sized CCC increases circumferential strains and decreases meridional strains by up to ∼20{\%} and that curvatures change by up to ∼13{\%}, particularly near the edge of the CCC. We submit that such changes can induce mechanobiological responses that are responsible, in part, for some of the long-term complications following cataract surgery.",
keywords = "Accommodation, Biomechanics, Cataracts, Stiffness, Stress",
author = "Heistand, {M. R.} and Pedrigi, {R. M.} and J. Dziezyc and Humphrey, {J. D.}",
year = "2006",
month = "8",
day = "28",
doi = "10.1016/j.jbiomech.2005.04.019",
language = "English (US)",
volume = "39",
pages = "1537--1542",
journal = "Journal of Biomechanics",
issn = "0021-9290",
publisher = "Elsevier Limited",
number = "8",

}

TY - JOUR

T1 - Redistribution of strain and curvature in the porcine anterior lens capsule following a continuous circular capsulorhexis

AU - Heistand, M. R.

AU - Pedrigi, R. M.

AU - Dziezyc, J.

AU - Humphrey, J. D.

PY - 2006/8/28

Y1 - 2006/8/28

N2 - Cataract surgery is the most commonly performed surgical procedure in the US, it consists of three steps: introduction of a hole into the lens capsule, removal of the clouded lens through this access hole, and insertion of an artificial lens. We hypothesize that errant behavior by the residual epithelial cells of the lens capsule following surgery are due, in part, to surgically-induced changes of the native stress and strain fields in the lens capsule. Because the capsular bag can be regarded mechanically as a membrane, here we study changes in curvature and strains due to the most common means of introducing the initial access hole: a continuous circular capsulorhexis (CCC). We show that a modest sized CCC increases circumferential strains and decreases meridional strains by up to ∼20% and that curvatures change by up to ∼13%, particularly near the edge of the CCC. We submit that such changes can induce mechanobiological responses that are responsible, in part, for some of the long-term complications following cataract surgery.

AB - Cataract surgery is the most commonly performed surgical procedure in the US, it consists of three steps: introduction of a hole into the lens capsule, removal of the clouded lens through this access hole, and insertion of an artificial lens. We hypothesize that errant behavior by the residual epithelial cells of the lens capsule following surgery are due, in part, to surgically-induced changes of the native stress and strain fields in the lens capsule. Because the capsular bag can be regarded mechanically as a membrane, here we study changes in curvature and strains due to the most common means of introducing the initial access hole: a continuous circular capsulorhexis (CCC). We show that a modest sized CCC increases circumferential strains and decreases meridional strains by up to ∼20% and that curvatures change by up to ∼13%, particularly near the edge of the CCC. We submit that such changes can induce mechanobiological responses that are responsible, in part, for some of the long-term complications following cataract surgery.

KW - Accommodation

KW - Biomechanics

KW - Cataracts

KW - Stiffness

KW - Stress

UR - http://www.scopus.com/inward/record.url?scp=33747585597&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33747585597&partnerID=8YFLogxK

U2 - 10.1016/j.jbiomech.2005.04.019

DO - 10.1016/j.jbiomech.2005.04.019

M3 - Article

C2 - 16024027

AN - SCOPUS:33747585597

VL - 39

SP - 1537

EP - 1542

JO - Journal of Biomechanics

JF - Journal of Biomechanics

SN - 0021-9290

IS - 8

ER -