Recurrent aspiration in children: Lipid‐laden alveolar macrophage quantitation

John Louis Colombo, T. K. Hallberg

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

We prospectively evaluated bronchial washings from 45 patients aged 1 month to 25 years (mean 3.3 years) for the presence of lipid‐laden macrophages. By grading the amount of intracellular oil‐red‐O‐positive material, we determined a semiquantitative lipid‐laden macrophage index for each patient. All patients observed to be definite aspirators (n = 22) had indexes ≥86 (mean ± SD, 139 ± 46). All patients with no clinical suspicion of aspiration (n = 23) had indexes ⩽72 (mean ± SD, 21 ± 20). Our results suggest that simply sighting lipid‐laden macrophages is a nonspecific finding, but quantitation of these cells may be a very good test for recurrent aspiration of food substances in children. This test appears to be more sensitive than radiographic studies. Pediatr Pulmonol 1987; 3:89–89.

Original languageEnglish (US)
Pages (from-to)86-89
Number of pages4
JournalPediatric Pulmonology
Volume3
Issue number2
DOIs
StatePublished - Jan 1 1987

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Alveolar Macrophages
Macrophages
Food

Keywords

  • Aspiration pneumonia
  • bronchial washings
  • bronchoscopy
  • intracellular oil‐red‐O‐positive grading

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Recurrent aspiration in children : Lipid‐laden alveolar macrophage quantitation. / Colombo, John Louis; Hallberg, T. K.

In: Pediatric Pulmonology, Vol. 3, No. 2, 01.01.1987, p. 86-89.

Research output: Contribution to journalArticle

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