Reconstruction of anorganic mammalian bone by surface-initiated polymerization of L-lactide

Troy Wiegand, Jeremy Karr, Jay D. Steinkruger, Kris Hiebner, Bobby Simetich, Mark W Beatty, Jody Redepenning

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Polymerization of L-lactide within the pores of anorganic mammalian bone is described. No additional solvent or catalyst is used. The resulting composites exhibit macroscopic morphologies and mechanical properties similar to that of the original bone. We observe an average compressive strength of 194 MPa and an elastic modulus of 8.8 GPa for composites comprised of poly-L-lactide and anorganic bone derived from bovine femurs. Modeling of the reaction kinetics with synthetic sources of crystalline hydroxyapatite powder suggests that polymerization proceeds via a surface-initiated mechanism that is first order in surface area of hydroxyapatite and first order in mole fraction of L-lactide.

Original languageEnglish (US)
Pages (from-to)5016-5022
Number of pages7
JournalChemistry of Materials
Volume20
Issue number15
DOIs
StatePublished - Aug 12 2008

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Bone
Polymerization
Durapatite
Hydroxyapatite
Composite materials
Reaction kinetics
Powders
Compressive strength
Elastic moduli
Crystalline materials
Mechanical properties
Catalysts
dilactide
poly(lactide)

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Materials Chemistry

Cite this

Wiegand, T., Karr, J., Steinkruger, J. D., Hiebner, K., Simetich, B., Beatty, M. W., & Redepenning, J. (2008). Reconstruction of anorganic mammalian bone by surface-initiated polymerization of L-lactide. Chemistry of Materials, 20(15), 5016-5022. https://doi.org/10.1021/cm800895r

Reconstruction of anorganic mammalian bone by surface-initiated polymerization of L-lactide. / Wiegand, Troy; Karr, Jeremy; Steinkruger, Jay D.; Hiebner, Kris; Simetich, Bobby; Beatty, Mark W; Redepenning, Jody.

In: Chemistry of Materials, Vol. 20, No. 15, 12.08.2008, p. 5016-5022.

Research output: Contribution to journalArticle

Wiegand, T, Karr, J, Steinkruger, JD, Hiebner, K, Simetich, B, Beatty, MW & Redepenning, J 2008, 'Reconstruction of anorganic mammalian bone by surface-initiated polymerization of L-lactide', Chemistry of Materials, vol. 20, no. 15, pp. 5016-5022. https://doi.org/10.1021/cm800895r
Wiegand, Troy ; Karr, Jeremy ; Steinkruger, Jay D. ; Hiebner, Kris ; Simetich, Bobby ; Beatty, Mark W ; Redepenning, Jody. / Reconstruction of anorganic mammalian bone by surface-initiated polymerization of L-lactide. In: Chemistry of Materials. 2008 ; Vol. 20, No. 15. pp. 5016-5022.
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