Recombination factors of Saccharomyces cerevisiae

Patrick Sung, Kelly M Trujillo, Stephen Van Komen

Research output: Contribution to journalReview article

151 Citations (Scopus)

Abstract

The budding yeast Saccharomyces cerevisiae has been an excellent genetic and biochemical model for our understanding of homologous recombination. Central to the process of homologous recombination are the products of the RAD52 epistasis group of genes, whose functions we now know include the nucleolytic processing of DNA double-stand breaks, the ability to conduct a DNA homology search, and the capacity to promote the exchange of genetic information between homologous regions on recombining chromosomes. It is also clear that the basic functions of the RAD52 group of genes have been highly conserved among eukaryotes. Disruption of this important process causes genomic instability, which can result in a number of unsavory consequences, including tumorigenesis and cell death. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)257-275
Number of pages19
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume451
Issue number1-2
DOIs
StatePublished - Jun 30 2000

Fingerprint

Homologous Recombination
Genetic Recombination
Saccharomyces cerevisiae
Saccharomycetales
Genomic Instability
Genetic Models
DNA
Eukaryota
Genes
Carcinogenesis
Cell Death
Chromosomes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

Cite this

Recombination factors of Saccharomyces cerevisiae. / Sung, Patrick; Trujillo, Kelly M; Van Komen, Stephen.

In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 451, No. 1-2, 30.06.2000, p. 257-275.

Research output: Contribution to journalReview article

Sung, Patrick ; Trujillo, Kelly M ; Van Komen, Stephen. / Recombination factors of Saccharomyces cerevisiae. In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 2000 ; Vol. 451, No. 1-2. pp. 257-275.
@article{c47b1f50d1c845649bf358c95e84ef16,
title = "Recombination factors of Saccharomyces cerevisiae",
abstract = "The budding yeast Saccharomyces cerevisiae has been an excellent genetic and biochemical model for our understanding of homologous recombination. Central to the process of homologous recombination are the products of the RAD52 epistasis group of genes, whose functions we now know include the nucleolytic processing of DNA double-stand breaks, the ability to conduct a DNA homology search, and the capacity to promote the exchange of genetic information between homologous regions on recombining chromosomes. It is also clear that the basic functions of the RAD52 group of genes have been highly conserved among eukaryotes. Disruption of this important process causes genomic instability, which can result in a number of unsavory consequences, including tumorigenesis and cell death. Copyright (C) 2000 Elsevier Science B.V.",
author = "Patrick Sung and Trujillo, {Kelly M} and {Van Komen}, Stephen",
year = "2000",
month = "6",
day = "30",
doi = "10.1016/S0027-5107(00)00054-3",
language = "English (US)",
volume = "451",
pages = "257--275",
journal = "Mutation Research",
issn = "1386-1964",
publisher = "Elsevier BV",
number = "1-2",

}

TY - JOUR

T1 - Recombination factors of Saccharomyces cerevisiae

AU - Sung, Patrick

AU - Trujillo, Kelly M

AU - Van Komen, Stephen

PY - 2000/6/30

Y1 - 2000/6/30

N2 - The budding yeast Saccharomyces cerevisiae has been an excellent genetic and biochemical model for our understanding of homologous recombination. Central to the process of homologous recombination are the products of the RAD52 epistasis group of genes, whose functions we now know include the nucleolytic processing of DNA double-stand breaks, the ability to conduct a DNA homology search, and the capacity to promote the exchange of genetic information between homologous regions on recombining chromosomes. It is also clear that the basic functions of the RAD52 group of genes have been highly conserved among eukaryotes. Disruption of this important process causes genomic instability, which can result in a number of unsavory consequences, including tumorigenesis and cell death. Copyright (C) 2000 Elsevier Science B.V.

AB - The budding yeast Saccharomyces cerevisiae has been an excellent genetic and biochemical model for our understanding of homologous recombination. Central to the process of homologous recombination are the products of the RAD52 epistasis group of genes, whose functions we now know include the nucleolytic processing of DNA double-stand breaks, the ability to conduct a DNA homology search, and the capacity to promote the exchange of genetic information between homologous regions on recombining chromosomes. It is also clear that the basic functions of the RAD52 group of genes have been highly conserved among eukaryotes. Disruption of this important process causes genomic instability, which can result in a number of unsavory consequences, including tumorigenesis and cell death. Copyright (C) 2000 Elsevier Science B.V.

UR - http://www.scopus.com/inward/record.url?scp=0034733599&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034733599&partnerID=8YFLogxK

U2 - 10.1016/S0027-5107(00)00054-3

DO - 10.1016/S0027-5107(00)00054-3

M3 - Review article

VL - 451

SP - 257

EP - 275

JO - Mutation Research

JF - Mutation Research

SN - 1386-1964

IS - 1-2

ER -